Publications
62 results found
Linneweber GA, Jacobson J, Busch KE, et al., 2014, Neuronal control of metabolism through nutrient-dependent modulation of tracheal branching, Cell, Vol: 156, Pages: 69-83, ISSN: 0092-8674
During adaptive angiogenesis, a key process in the etiology and treatment of cancer and obesity, the vasculature changes to meet the metabolic needs of its target tissues. Although the cues governing vascular remodeling are not fully understood, target-derived signals are generally believed to underlie this process. Here, we identify an alternative mechanism by characterizing the previously unrecognized nutrient-dependent plasticity of the Drosophila tracheal system: a network of oxygen-delivering tubules developmentally akin to mammalian blood vessels. We find that this plasticity, particularly prominent in the intestine, drives—rather than responds to—metabolic change. Mechanistically, it is regulated by distinct populations of nutrient- and oxygen-responsive neurons that, through delivery of both local and systemic insulin- and VIP-like neuropeptides, sculpt the growth of specific tracheal subsets. Thus, we describe a novel mechanism by which nutritional cues modulate neuronal activity to give rise to organ-specific, long-lasting changes in vascular architecture.
Sarraf-Zadeh L, Christen S, Sauer U, et al., 2013, Local requirement of the <i>Drosophila</i> insulin binding protein imp-L2 in coordinating developmental progression with nutritional conditions, DEVELOPMENTAL BIOLOGY, Vol: 381, Pages: 97-106, ISSN: 0012-1606
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- Citations: 25
Lemaitre B, Miguel-Aliaga I, 2013, The Digestive Tract of <i>Drosophila melanogaster</i>, ANNUAL REVIEW OF GENETICS, VOL 47, Vol: 47, Pages: 377-404, ISSN: 0066-4197
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- Citations: 294
Miguel-Aliaga I, Oliver B, Teleman AA, 2012, The flies of Icarus: science with wings in Crete, EMBO REPORTS, Vol: 13, Pages: 945-947, ISSN: 1469-221X
Oyallon J, Apitz H, Miguel-Aliaga I, et al., 2012, Regulation of locomotion and motoneuron trajectory selection and targeting by the <i>Drosophila</i> homolog of Olig family transcription factors, DEVELOPMENTAL BIOLOGY, Vol: 369, Pages: 261-276, ISSN: 0012-1606
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- Citations: 18
Miguel-Aliaga I, 2012, Nerveless and gutsy: intestinal nutrient sensing from invertebrates to humans, SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, Vol: 23, Pages: 614-620, ISSN: 1084-9521
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- Citations: 34
Talsma AD, Christov CP, Terriente-Felix A, et al., 2012, Remote control of renal physiology by the intestinal neuropeptide pigment-dispersing factor in <i>Drosophila</i>, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 109, Pages: 12177-12182, ISSN: 0027-8424
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- Citations: 46
Cognigni P, Bailey AP, Miguel-Aliaga I, 2012, Enteric Neurons and Systemic Signals Couple Nutritional and Reproductive Status with Intestinal Homeostasis (vol 13, pg 104, 2011), CELL METABOLISM, Vol: 15, Pages: 128-128, ISSN: 1550-4131
Pulver SR, Cognigni P, Denholm B, et al., 2011, Why flies? Inexpensive public engagement exercises to explain the value of basic biomedical research on <i>Drosophila melanogaster</i>, ADVANCES IN PHYSIOLOGY EDUCATION, Vol: 35, Pages: 384-392, ISSN: 1043-4046
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- Citations: 5
Suska A, Miguel-Aliaga I, Thor S, 2011, Segment-specific generation of <i>Drosophila</i> Capability neuropeptide neurons by multi-faceted Hox cues, DEVELOPMENTAL BIOLOGY, Vol: 353, Pages: 72-80, ISSN: 0012-1606
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- Citations: 36
Cognigni P, Bailey AP, Miguel-Aliaga I, 2011, Enteric Neurons and Systemic Signals Couple Nutritional and Reproductive Status with Intestinal Homeostasis, CELL METABOLISM, Vol: 13, Pages: 92-104, ISSN: 1550-4131
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- Citations: 209
Cognigni P, Thorne J, Bailey AP, et al., 2010, The autonomic nervous system: does the body rule the mind, or does the mind rule the body?, Publisher: INFORMA HEALTHCARE, Pages: 10-10, ISSN: 0167-7063
Cognigni P, Linneweber G, Bailey A, et al., 2009, Development and function of visceral innervation in <i>Drosophila</i>, 16th Annual Conference of the International-Society-of-Development-Biologists, Publisher: ELSEVIER SCIENCE BV, Pages: S190-S190, ISSN: 0925-4773
Miguel-Aliaga I, Thor S, 2009, Programmed cell death in the nervous system-a programmed cell fate?, CURRENT OPINION IN NEUROBIOLOGY, Vol: 19, Pages: 127-133, ISSN: 0959-4388
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- Citations: 15
Miguel-Aliaga I, Cognigni P, Groenke S, et al., 2009, Development and physiology of enteric neurons in <i>Drosophila</i>, Publisher: WILEY, Pages: XIX-XIX, ISSN: 1350-1925
Bardet P-L, Kolahgar G, Mynett A, et al., 2008, A fluorescent reporter of caspase activity for live imaging, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 105, Pages: 13901-13905, ISSN: 0027-8424
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- Citations: 121
Miguel-Aliaga I, Thor S, Gould AP, 2008, Postmitotic specification of <i>Drosophila</i> insulinergic neurons from pioneer neurons, PLOS BIOLOGY, Vol: 6, Pages: 538-551, ISSN: 1545-7885
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- Citations: 91
Sheldon TJ, Miguel-Aliaga I, Gould AP, et al., 2007, A novel family of single VWC-domain proteins in invertebrates, FEBS LETTERS, Vol: 581, Pages: 5268-5274, ISSN: 0014-5793
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- Citations: 33
Baumgardt M, Miguel-Aliaga I, Karlsson D, et al., 2007, Specification of neuronal identities by feedforward combinatorial coding., PLOS Biology, Vol: 5, ISSN: 1545-7885
Neuronal specification is often seen as a multistep process: earlier regulators confer broad neuronal identity and are followed by combinatorial codes specifying neuronal properties unique to specific subtypes. However, it is still unclear whether early regulators are re-deployed in subtype-specific combinatorial codes, and whether early patterning events act to restrict the developmental potential of postmitotic cells. Here, we use the differential peptidergic fate of two lineage-related peptidergic neurons in the Drosophila ventral nerve cord to show how, in a feedforward mechanism, earlier determinants become critical players in later combinatorial codes. Amongst the progeny of neuroblast 5-6 are two peptidergic neurons: one expresses FMRFamide and the other one expresses Nplp1 and the dopamine receptor DopR. We show the HLH gene collier functions at three different levels to progressively restrict neuronal identity in the 5-6 lineage. At the final step, collier is the critical combinatorial factor that differentiates two partially overlapping combinatorial codes that define FMRFamide versus Nplp1/DopR identity. Misexpression experiments reveal that both codes can activate neuropeptide gene expression in vast numbers of neurons. Despite their partially overlapping composition, we find that the codes are remarkably specific, with each code activating only the proper neuropeptide gene. These results indicate that a limited number of regulators may constitute a potent combinatorial code that dictates unique neuronal cell fate, and that such codes show a surprising disregard for many global instructive cues.
Miguel-Aliaga I, Allan DW, Thor S, 2004, Independent roles of the <i>Dachshund</i> and <i>Eyes Absent</i> genes in BMP signaling, axon pathfinding and neuronal specification, DEVELOPMENT, Vol: 131, Pages: 5837-5848, ISSN: 0950-1991
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- Citations: 51
Miguel-Aliaga I, Thor S, 2004, Segment-specific prevention of pioneer neuron apoptosis by cellautonomous, postmitotic Hox gene activity, DEVELOPMENT, Vol: 131, Pages: 6093-6105, ISSN: 0950-1991
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- Citations: 94
Chan YB, Miguel-Aliaga I, Franks C, et al., 2003, Neuromuscular defects in a Drosophila survival motor neuron gene mutant, Human Molecular Genetics, Vol: 12, Pages: 1367-1376, ISSN: 0964-6906
Autosomal recessive spinal muscular atrophy (SMA) is linked to mutations in the survival motor neuron (SMN) gene. The SMN protein has been implicated at several levels of mRNA biogenesis and is expressed ubiquitously. Studies in various model organisms have shown that the loss of function of the SMN gene leads to embryonic lethality. The human contains two genes encoding for SMN protein and in patients one of these is disrupted. It is thought the remaining low levels of protein produced by the second SMN gene do not suffice and result in the observed specific loss of lower motor neurons and muscle wasting. The early lethality in the animal mutants has made it difficult to understand why primarily these tissues are affected. We have isolated a Drosophila smn mutant. The fly alleles contain point mutations in smn similar to those found in SMA patients. We find that zygotic smn mutant animals show abnormal motor behavior and that smn gene activity is required in both neurons and muscle to alleviate this phenotype. Physiological experiments on the fly smn mutants show that excitatory post-synaptic currents are reduced while synaptic motor neuron boutons are disorganized, indicating defects at the neuromuscular junction. Clustering of a neurotransmitter receptor subunit in the muscle at the neuromuscular junction is severely reduced. This new Drosophila model for SMA thus proposes a functional role for SMN at the neuromuscular junction in the generation of neuromuscular defects.
Chan YB, Miguel-Aliaga I, Franks C, et al., 2003, Neuromuscular defects in a <i>Drosophila</i> survival motor neuron gene mutant, HUMAN MOLECULAR GENETICS, Vol: 12, Pages: 1367-1376, ISSN: 0964-6906
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- Citations: 155
Allan DW, St Pierre SE, Miguel-Aliaga I, et al., 2003, Specification of neuropeptide cell identity by the integration of retrograde BMP signaling and a combinatorial transcription factor code, CELL, Vol: 113, Pages: 73-86, ISSN: 0092-8674
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- Citations: 134
Vargas JD, Culetto E, Ponting CP, et al., 2002, Cloning and developmental expression analysis of <i>ltd-1</i>, the <i>Caenorhabditis elegans</i> homologue of the mouse <i>kyphoscoliosis</i> (<i>ky</i>) gene, MECHANISMS OF DEVELOPMENT, Vol: 117, Pages: 289-292, ISSN: 0925-4773
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- Citations: 9
Miguel-Aliaga I, Chan YB, Davies KE, et al., 2000, Disruption of SMN function by ectopic expression of the human SMN gene in <i>Drosophila</i>, FEBS LETTERS, Vol: 486, Pages: 99-102, ISSN: 0014-5793
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- Citations: 49
Burt EC, Miguel-Aliaga I, Culetto E, et al., 2000, The function and interactions orthologue of the SMN gene: CeSMN, Publisher: BLACKWELL SCIENCE LTD, Pages: 104-104, ISSN: 0953-816X
Miguel-Aliaga I, Culetto E, Walker DS, et al., 1999, The <i>Caenorhabditis</i> <i>elegans</i> orthologue of the human gene responsible for spinal muscular atrophy is a maternal product critical for germline maturation and embryonic viability, HUMAN MOLECULAR GENETICS, Vol: 8, Pages: 2133-2143, ISSN: 0964-6906
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- Citations: 103
Owen N, Miguel-Aliaga I, Culetto E, et al., 1999, Functional analysis of <i>C.elegans</i> and <i>S.pombe</i> orthologues of the human Survival Motor Neuron (SMN) protein., Publisher: UNIV CHICAGO PRESS, Pages: A483-A483, ISSN: 0002-9297
Talbot K, Miguel-Aliaga I, Mohaghegh P, et al., 1998, Characterization of a gene encoding Survival Motor Neuron (SMN)-related protein, a constituent of the spliceosome complex, HUMAN MOLECULAR GENETICS, Vol: 7, Pages: 2149-2156, ISSN: 0964-6906
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- Citations: 59
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