Imperial College London
Alternate

Professor Irene Miguel-Aliaga

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Professor of Genetics and Physiology
 
 
 
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Contact

 

+44 (0)20 3383 3907i.miguel-aliaga Website

 
 
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Location

 

232ICTEM buildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Hudry:2019:10.1016/j.cell.2019.07.029,
author = {Hudry, B and de, Goeij E and Mineo, A and Gaspar, P and Hadjieconomou, D and Studd, C and Mokochinski, J and Kramer, H and Plaçais, P-Y and Preat, T and Miguel-Aliaga, I},
doi = {10.1016/j.cell.2019.07.029},
journal = {Cell},
pages = {901--918.e16},
title = {Sex differences in intestinal carbohydrate metabolism promote food intake and sperm maturation},
url = {http://dx.doi.org/10.1016/j.cell.2019.07.029},
volume = {178},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Physiology and metabolism are often sexually dimorphic, but the underlying mechanisms remainincompletely understood. Here, we use the intestine of Drosophila melanogaster to investigate howgut-derived signals contribute to sex differences in whole-body physiology. We find thatcarbohydrate handling is male-biased in a specific portion of the intestine. In contrast to knownsexual dimorphisms in invertebrates, the sex differences in intestinal carbohydrate metabolism areextrinsically controlled by the adjacent male gonad, which activates JAK-STAT signalling inenterocytes within this intestinal portion. Sex reversal experiments establish roles for this malebiased intestinal metabolic state in controlling food intake and sperm production through gutderived citrate. Our work uncovers a male gonad-gut axis coupling diet and sperm production, andreveals that metabolic communication across organs is physiologically significant. The instructiverole of citrate in inter-organ communication may be significant in more biological contexts thanpreviously recognised.
AU  - Hudry,B
AU  - de,Goeij E
AU  - Mineo,A
AU  - Gaspar,P
AU  - Hadjieconomou,D
AU  - Studd,C
AU  - Mokochinski,J
AU  - Kramer,H
AU  - Plaçais,P-Y
AU  - Preat,T
AU  - Miguel-Aliaga,I
DO  - 10.1016/j.cell.2019.07.029
EP  - 918
PY  - 2019///
SN  - 0092-8674
SP  - 901
TI  - Sex differences in intestinal carbohydrate metabolism promote food intake and sperm maturation
T2  - Cell
UR  - http://dx.doi.org/10.1016/j.cell.2019.07.029
UR  - https://www.sciencedirect.com/science/article/pii/S0092867419307962?via%3Dihub
UR  - http://hdl.handle.net/10044/1/71959
VL  - 178
ER  -
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