Imperial College London
Alternate

Professor Irene Miguel-Aliaga

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Professor of Genetics and Physiology
 
 
 
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Contact

 

+44 (0)20 3383 3907i.miguel-aliaga Website

 
 
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Location

 

232ICTEM buildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Ameku:2020:10.1016/j.conb.2019.12.004,
author = {Ameku, T and Beckwith, H and Blackie, L and Miguel-Aliaga, I},
doi = {10.1016/j.conb.2019.12.004},
journal = {Current Opinion in Neurobiology},
pages = {83--91},
title = {Food, microbes, sex and old age: on the plasticity of gastrointestinal innervation},
url = {http://dx.doi.org/10.1016/j.conb.2019.12.004},
volume = {62},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The gastrointestinal tract is innervated by its own enteric nervous system and by extrinsic neurons that connect it with the central nervous system. Innervation allows the gastrointestinal tract to sense and respond to diverse stimuli, adjusting motility and secretion, but also affecting our physiology, behaviour and immunity. The mechanisms underlying the formation of gastrointestinal neurons are beginning to be elucidated; those that keep them plastic over an organism's lifetime remain to be explored. Here, we review the effects of microbiota, nutrients, sex and ageing on the morphology and function of gastrointestinal innervation in mammals, and discuss how this plasticity shapes gut-brain crosstalk and whole-body physiology. We also highlight insights gained by nascent studies of the enteric innervation of Drosophila melanogaster.
AU  - Ameku,T
AU  - Beckwith,H
AU  - Blackie,L
AU  - Miguel-Aliaga,I
DO  - 10.1016/j.conb.2019.12.004
EP  - 91
PY  - 2020///
SN  - 0959-4388
SP  - 83
TI  - Food, microbes, sex and old age: on the plasticity of gastrointestinal innervation
T2  - Current Opinion in Neurobiology
UR  - http://dx.doi.org/10.1016/j.conb.2019.12.004
UR  - https://www.ncbi.nlm.nih.gov/pubmed/32028080
UR  - http://hdl.handle.net/10044/1/76790
VL  - 62
ER  -
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