Imperial College London
Alternate

Professor Irene Miguel-Aliaga

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Professor of Genetics and Physiology
 
 
 
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Contact

 

+44 (0)20 3383 3907i.miguel-aliaga Website

 
 
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Location

 

232ICTEM buildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Millington:2021:10.7554/eLife.58341,
author = {Millington, JW and Brownrigg, GP and Chao, C and Sun, Z and Basner-Collins, PJ and Wat, LW and Hudry, B and Miguel-Aliaga, I and Rideout, EJ},
doi = {10.7554/eLife.58341},
journal = {eLife},
pages = {1--36},
title = {Female-blase upregulation of insulin pathway activity mediates the sex difference in Drosophila body size plasticity},
url = {http://dx.doi.org/10.7554/eLife.58341},
volume = {10},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Nutrient-dependent body size plasticity differs between the sexes in most species, including mammals. Previous work in Drosophila showed that body size plasticity was higher in females, yet the mechanisms underlying increased female body size plasticity remain unclear. Here, we discover that a protein-rich diet augments body size in females and not males because of a female-biased increase in activity of the conserved insulin/insulin-like growth factor signaling pathway (IIS). This sex-biased upregulation of IIS activity was triggered by a diet-induced increase in stunted mRNA in females, and required Drosophila insulin-like peptide 2, illuminating new sex-specific roles for these genes. Importantly, we show that sex determination gene transformer promotes the diet-induced increase in stunted mRNA via transcriptional coactivator Spargel to regulate the male-female difference in body size plasticity. Together, these findings provide vital insight into conserved mechanisms underlying the sex difference in nutrient-dependent body size plasticity.
AU  - Millington,JW
AU  - Brownrigg,GP
AU  - Chao,C
AU  - Sun,Z
AU  - Basner-Collins,PJ
AU  - Wat,LW
AU  - Hudry,B
AU  - Miguel-Aliaga,I
AU  - Rideout,EJ
DO  - 10.7554/eLife.58341
EP  - 36
PY  - 2021///
SN  - 2050-084X
SP  - 1
TI  - Female-blase upregulation of insulin pathway activity mediates the sex difference in Drosophila body size plasticity
T2  - eLife
UR  - http://dx.doi.org/10.7554/eLife.58341
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000618526800001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://elifesciences.org/articles/58341
UR  - http://hdl.handle.net/10044/1/88456
VL  - 10
ER  -
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