Imperial College London
Alternate

Professor Irene Miguel-Aliaga

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Professor of Genetics and Physiology
 
 
 
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Contact

 

+44 (0)20 3383 3907i.miguel-aliaga Website

 
 
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Location

 

232ICTEM buildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Cable:2021:10.1111/nyas.14678,
author = {Cable, J and Pourquie, O and Wellen, KE and Finley, LWS and Aulehla, A and Gould, AP and Teleman, A and Tu, WB and Garrett, WS and Miguel-Aliaga, I and Perrimon, N and Hooper, LV and Walhout, AJM and Wei, W and Alexandrov, T and Erez, A and Ralser, M and Rabinowitz, JD and Hemalatha, A and Gutierrez-Perez, P and Chandel, NS and Rutter, J and Locasale, JW and Landoni, JC and Christofk, H},
doi = {10.1111/nyas.14678},
journal = {Annals of the New York Academy of Sciences},
pages = {55--73},
title = {Metabolic decisions in development and disease-a Keystone Symposia report},
url = {http://dx.doi.org/10.1111/nyas.14678},
volume = {1506},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - There is an increasing appreciation for the role of metabolism in cell signaling and cell decision making. Precise metabolic control is essential in development, as evident by the disorders caused by mutations in metabolic enzymes. The metabolic profile of cells is often cell-type specific, changing as cells differentiate or during tumorigenesis. Recent evidence has shown that changes in metabolism are not merely a consequence of changes in cell state but that metabolites can serve to promote and/or inhibit these changes. Metabolites can link metabolic pathways with cell signaling pathways via several mechanisms, for example, by serving as substrates for protein post-translational modifications, by affecting enzyme activity via allosteric mechanisms, or by altering epigenetic markers. Unraveling the complex interactions governing metabolism, gene expression, and protein activity that ultimately govern a cell's fate will require new tools and interactions across disciplines. On March 24 and 25, 2021, experts in cell metabolism, developmental biology, and human disease met virtually for the Keystone eSymposium, “Metabolic Decisions in Development and Disease.” The discussions explored how metabolites impact cellular and developmental decisions in a diverse range of model systems used to investigate normal development, developmental disorders, dietary effects, and cancer-mediated changes in metabolism.
AU  - Cable,J
AU  - Pourquie,O
AU  - Wellen,KE
AU  - Finley,LWS
AU  - Aulehla,A
AU  - Gould,AP
AU  - Teleman,A
AU  - Tu,WB
AU  - Garrett,WS
AU  - Miguel-Aliaga,I
AU  - Perrimon,N
AU  - Hooper,LV
AU  - Walhout,AJM
AU  - Wei,W
AU  - Alexandrov,T
AU  - Erez,A
AU  - Ralser,M
AU  - Rabinowitz,JD
AU  - Hemalatha,A
AU  - Gutierrez-Perez,P
AU  - Chandel,NS
AU  - Rutter,J
AU  - Locasale,JW
AU  - Landoni,JC
AU  - Christofk,H
DO  - 10.1111/nyas.14678
EP  - 73
PY  - 2021///
SN  - 0077-8923
SP  - 55
TI  - Metabolic decisions in development and disease-a Keystone Symposia report
T2  - Annals of the New York Academy of Sciences
UR  - http://dx.doi.org/10.1111/nyas.14678
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000686432900001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://nyaspubs.onlinelibrary.wiley.com/doi/10.1111/nyas.14678
UR  - http://hdl.handle.net/10044/1/94220
VL  - 1506
ER  -
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