Imperial College London
Alternate

Professor Irene Miguel-Aliaga

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Professor of Genetics and Physiology
 
 
 
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Contact

 

+44 (0)20 3383 3907i.miguel-aliaga Website

 
 
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Location

 

232ICTEM buildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Imambocus:2022:10.1016/j.cub.2021.10.069,
author = {Imambocus, BN and Zhou, F and Formozov, A and Wittich, A and Tenedini, FM and Hu, C and Sauter, K and Macarenhas, Varela E and Herédia, F and Casimiro, AP and Macedo, A and Schlegel, P and Yang, C-H and Miguel-Aliaga, I and Wiegert, JS and Pankratz, MJ and Gontijo, AM and Cardona, A and Soba, P},
doi = {10.1016/j.cub.2021.10.069},
journal = {Current Biology},
pages = {149--163.e8},
title = {A neuropeptidergic circuit gates selective escape behavior of Drosophila larvae},
url = {http://dx.doi.org/10.1016/j.cub.2021.10.069},
volume = {32},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Animals display selective escape behaviors when faced with environmental threats. Selection of the appropriate response by the underlying neuronal network is key to maximizing chances of survival, yet the underlying network mechanisms are so far not fully understood. Using synapse-level reconstruction of the Drosophila larval network paired with physiological and behavioral readouts, we uncovered a circuit that gates selective escape behavior for noxious light through acute and input-specific neuropeptide action. Sensory neurons required for avoidance of noxious light and escape in response to harsh touch, each converge on discrete domains of neuromodulatory hub neurons. We show that acute release of hub neuron-derived insulin-like peptide 7 (Ilp7) and cognate relaxin family receptor (Lgr4) signaling in downstream neurons are required for noxious light avoidance, but not harsh touch responses. Our work highlights a role for compartmentalized circuit organization and neuropeptide release from regulatory hubs, acting as central circuit elements gating escape responses.
AU  - Imambocus,BN
AU  - Zhou,F
AU  - Formozov,A
AU  - Wittich,A
AU  - Tenedini,FM
AU  - Hu,C
AU  - Sauter,K
AU  - Macarenhas,Varela E
AU  - Herédia,F
AU  - Casimiro,AP
AU  - Macedo,A
AU  - Schlegel,P
AU  - Yang,C-H
AU  - Miguel-Aliaga,I
AU  - Wiegert,JS
AU  - Pankratz,MJ
AU  - Gontijo,AM
AU  - Cardona,A
AU  - Soba,P
DO  - 10.1016/j.cub.2021.10.069
EP  - 163
PY  - 2022///
SN  - 0960-9822
SP  - 149
TI  - A neuropeptidergic circuit gates selective escape behavior of Drosophila larvae
T2  - Current Biology
UR  - http://dx.doi.org/10.1016/j.cub.2021.10.069
UR  - https://www.ncbi.nlm.nih.gov/pubmed/34798050
UR  - http://hdl.handle.net/10044/1/94232
VL  - 32
ER  -
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