Imperial College London
Alternate

Professor Irene Miguel-Aliaga

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Professor of Genetics and Physiology
 
 
 
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Contact

 

+44 (0)20 3383 3907i.miguel-aliaga Website

 
 
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Location

 

232ICTEM buildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Linneweber:2014:10.1016/j.cell.2013.12.008,
author = {Linneweber, GA and Jacobson, J and Busch, KE and Hudry, B and Christov, CP and Dormann, D and Yuan, M and Otani, T and Knust, E and de, Bono M and Miguel-Aliaga, I},
doi = {10.1016/j.cell.2013.12.008},
journal = {Cell},
pages = {69--83},
title = {Neuronal control of metabolism through nutrient-dependent modulation of tracheal branching},
url = {http://dx.doi.org/10.1016/j.cell.2013.12.008},
volume = {156},
year = {2014}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - During adaptive angiogenesis, a key process in the etiology and treatment of cancer and obesity, the vasculature changes to meet the metabolic needs of its target tissues. Although the cues governing vascular remodeling are not fully understood, target-derived signals are generally believed to underlie this process. Here, we identify an alternative mechanism by characterizing the previously unrecognized nutrient-dependent plasticity of the Drosophila tracheal system: a network of oxygen-delivering tubules developmentally akin to mammalian blood vessels. We find that this plasticity, particularly prominent in the intestine, drives—rather than responds to—metabolic change. Mechanistically, it is regulated by distinct populations of nutrient- and oxygen-responsive neurons that, through delivery of both local and systemic insulin- and VIP-like neuropeptides, sculpt the growth of specific tracheal subsets. Thus, we describe a novel mechanism by which nutritional cues modulate neuronal activity to give rise to organ-specific, long-lasting changes in vascular architecture.
AU  - Linneweber,GA
AU  - Jacobson,J
AU  - Busch,KE
AU  - Hudry,B
AU  - Christov,CP
AU  - Dormann,D
AU  - Yuan,M
AU  - Otani,T
AU  - Knust,E
AU  - de,Bono M
AU  - Miguel-Aliaga,I
DO  - 10.1016/j.cell.2013.12.008
EP  - 83
PY  - 2014///
SN  - 0092-8674
SP  - 69
TI  - Neuronal control of metabolism through nutrient-dependent modulation of tracheal branching
T2  - Cell
UR  - http://dx.doi.org/10.1016/j.cell.2013.12.008
UR  - http://hdl.handle.net/10044/1/36826
VL  - 156
ER  -
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