Imperial College London
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DrIngridMuller

Faculty of Medicine, Department of Infectious Disease

Visiting Reader
 
 
 
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i.muller

 
 
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Location

 

120Wright Fleming WingSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Takele:2022:10.1371/journal.pntd.0010544,
author = {Takele, Y and Adem, E and Franssen, SU and Womersley, RL and Kaforou, MC and Levin, ML and Mueller, IC and Cotton, JAL and Kropf, PC},
doi = {10.1371/journal.pntd.0010544},
journal = {PLoS Neglected Tropical Diseases},
pages = {1--12},
title = {Impaired in vitro Interferon-gamma production in patients with visceral leishmaniasis is improved by inhibition of PD1/PDL-1 ligation},
url = {http://dx.doi.org/10.1371/journal.pntd.0010544},
volume = {16},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Visceral leishmaniasis (VL) is a neglected tropical disease that causes substantial morbidity and mortality and is a growing health problem in Ethiopia, where this study took place. Most individuals infected with Leishmania donovani parasites will stay asymptomatic, but some develop VL that, if left untreated, is almost always fatal. This stage of the disease is associated with a profound immunosuppression, characterised by impaired production of Interferonγ (IFNγ), a cytokine that plays a key role in the control of Leishmania parasites, and high expression levels of an inhibitory receptor, programmed cell death 1 (PD1) on CD4+ T cells. Here, we tested the contribution of the interaction between the immune checkpoint PD1 and its ligand PDL-1 on the impaired production of IFNγ in VL patients. Our results show that in the blood of VL patients, not only CD4+, but also CD8+ T cells express high levels of PD1 at the time of VL diagnosis. Next, we identified PDL-1 expression on different monocyte subsets and neutrophils and show that PDL-1 levels were significantly increased in VL patients. PD1/PDL-1 inhibition resulted in significantly increased production of IFNγ, suggesting that therapy using immune checkpoint inhibitors might improve disease control in these patients.
AU  - Takele,Y
AU  - Adem,E
AU  - Franssen,SU
AU  - Womersley,RL
AU  - Kaforou,MC
AU  - Levin,ML
AU  - Mueller,IC
AU  - Cotton,JAL
AU  - Kropf,PC
DO  - 10.1371/journal.pntd.0010544
EP  - 12
PY  - 2022///
SN  - 1935-2727
SP  - 1
TI  - Impaired in vitro Interferon-gamma production in patients with visceral leishmaniasis is improved by inhibition of PD1/PDL-1 ligation
T2  - PLoS Neglected Tropical Diseases
UR  - http://dx.doi.org/10.1371/journal.pntd.0010544
UR  - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000841556000001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=a2bf6146997ec60c407a63945d4e92bb
UR  - https://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0010544
UR  - http://hdl.handle.net/10044/1/101657
VL  - 16
ER  -
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