Imperial College London
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DrIngridMuller

Faculty of Medicine, Department of Infectious Disease

Visiting Reader
 
 
 
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Contact

 

i.muller

 
 
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Location

 

120Wright Fleming WingSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Cloke:2012:10.1371/journal.pone.0048939,
author = {Cloke, T and Munder, M and Taylor, G and Mueller, I and Kropf, P},
doi = {10.1371/journal.pone.0048939},
journal = {PLOS One},
title = {Characterization of a novel population of low-density granulocytes associated with disease severity in HIV-1 infection},
url = {http://dx.doi.org/10.1371/journal.pone.0048939},
volume = {7},
year = {2012}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The mechanisms resulting in progressive immune dysfunction during the chronic phase of HIV infection are not fully understood. We have previously shown that arginase, an enzyme with potent immunosuppressive properties, is increased in HIV seropositive (HIV+) patients with low CD4+ T cell counts. Here we show that the cells expressing arginase in peripheral blood mononuclear cells of HIV+ patients are low-density granulocytes (LDGs) and that whereas these cells have a similar morphology to normal-density granulocyte, they are phenotypically different. Importantly, our results reveal that increased frequencies of LDGs correlate with disease severity in HIV+ patients.
AU  - Cloke,T
AU  - Munder,M
AU  - Taylor,G
AU  - Mueller,I
AU  - Kropf,P
DO  - 10.1371/journal.pone.0048939
PY  - 2012///
SN  - 1932-6203
TI  - Characterization of a novel population of low-density granulocytes associated with disease severity in HIV-1 infection
T2  - PLOS One
UR  - http://dx.doi.org/10.1371/journal.pone.0048939
UR  - http://hdl.handle.net/10044/1/32210
VL  - 7
ER  -
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