Imperial College London
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DrIngridMuller

Faculty of Medicine, Department of Infectious Disease

Visiting Reader
 
 
 
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i.muller

 
 
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120Wright Fleming WingSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Abebe:2013:10.1371/journal.pntd.0002134,
author = {Abebe, T and Takele, Y and Weldegebreal, T and Cloke, T and Closs, E and Corset, C and Hailu, A and Hailu, W and Sisay, Y and Corware, K and Corset, M and Modolell, M and Munder, M and Tacchini-Cottier, F and Mueller, I and Kropf, P},
doi = {10.1371/journal.pntd.0002134},
journal = {PLOS Neglected Tropical Diseases},
title = {Arginase activity - a marker of disease status in patients with visceral leishmaniasis in Ethiopia},
url = {http://dx.doi.org/10.1371/journal.pntd.0002134},
volume = {7},
year = {2013}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The underlying mechanisms resulting in the profound immune suppression characteristic of human visceral leishmaniasis (VL) are not fully understood.Here, we tested the hypothesis that arginase, an enzyme associated with immunosuppression, is higher in patients with VL and contributes to impaired T cell responses. We recruited patients with VL before and after treatment and healthy controls and measured the arginase metabolism in the blood of these individuals. Our results show that arginase activity is significantly higher in the blood of patients with active VL as compared to controls. These high levels of arginase decline considerably once the patients are successfully treated. We identified the phenotype of arginase-expressing cells among PBMCs as neutrophils and show that their frequency was increased in PBMCs of patients before treatment; this coincides with reduced levels of L-arginine in the plasma and decreased expression levels of CD3ζ in T cells.
AU  - Abebe,T
AU  - Takele,Y
AU  - Weldegebreal,T
AU  - Cloke,T
AU  - Closs,E
AU  - Corset,C
AU  - Hailu,A
AU  - Hailu,W
AU  - Sisay,Y
AU  - Corware,K
AU  - Corset,M
AU  - Modolell,M
AU  - Munder,M
AU  - Tacchini-Cottier,F
AU  - Mueller,I
AU  - Kropf,P
DO  - 10.1371/journal.pntd.0002134
PY  - 2013///
SN  - 1935-2735
TI  - Arginase activity - a marker of disease status in patients with visceral leishmaniasis in Ethiopia
T2  - PLOS Neglected Tropical Diseases
UR  - http://dx.doi.org/10.1371/journal.pntd.0002134
UR  - http://hdl.handle.net/10044/1/32215
VL  - 7
ER  -
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