Imperial College London
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DrIngridMuller

Faculty of Medicine, Department of Infectious Disease

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120Wright Fleming WingSt Mary's Campus

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Publications

Citation

BibTex format

@article{Mortazavi:2016:10.1111/jdv.13838,
author = {Mortazavi, H and Sadeghipour, P and Taslimi, Y and Habibzadeh, S and Zali, F and Zahedifard, F and Rahmati, J and Kamyab, K and Ghandi, N and Zamanian, A and Reza, Tohidinik H and Muller, I and Kropf, P and Rafati, S},
doi = {10.1111/jdv.13838},
journal = {Journal of the European Academy of Dermatology and Venereology},
pages = {2118--2121},
title = {Comparing acute and chronic human cutaneous leishmaniasis caused by Leishmania major and Leishmania tropica focusing on arginase activity.},
url = {http://dx.doi.org/10.1111/jdv.13838},
volume = {30},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BACKGROUND: Cutaneous leishmaniasis (CL) in Iran is mainly caused by Leishmania major (L. major) and L. tropica. Arginase mediated L-arginine metabolism is an important issue in Leishmania parasite propagation. Arginase activity in human CL due to L. major and L. tropica have not been studied up to now. OBJECTIVES: We aimed to compare the clinical and laboratory aspects of acute and chronic CL, focussing on arginase activity. METHODS: In this case-control study, 30 patients with acute CL (duration ≤ 1 year), 13 patients with chronic CL (duration ≥ 2 year) and 11 healthy controls were recruited. Arginase activity was measured in skin biopsies of lesions, peripheral blood polymorphonuclear cells (PMNs), peripheral blood mononuclear cells (PBMCs) and plasma by standard methods. RESULTS: The median of arginase activity in the acute lesions was higher than in chronic samples and significantly higher than in healthy controls (P = 0.008). PMNs of both acute and chronic patients showed higher levels of arginase activity as compared to the levels in PBMCs and plasma. The median of arginase activity in the PMNs of patients with chronic CL was higher than that of patients with acute CL and significantly higher than that of the healthy controls (P = 0.010). CONCLUSION: The level of arginase activity in lesions of patients with acute and chronic CL was higher than the skin of healthy controls. The highest level of arginase activity was observed in PMNs from patients with chronic CL. This suggests that the high level of arginase activity in PMNs of patients with chronic CL may contribute to the chronicity.
AU  - Mortazavi,H
AU  - Sadeghipour,P
AU  - Taslimi,Y
AU  - Habibzadeh,S
AU  - Zali,F
AU  - Zahedifard,F
AU  - Rahmati,J
AU  - Kamyab,K
AU  - Ghandi,N
AU  - Zamanian,A
AU  - Reza,Tohidinik H
AU  - Muller,I
AU  - Kropf,P
AU  - Rafati,S
DO  - 10.1111/jdv.13838
EP  - 2121
PY  - 2016///
SN  - 1468-3083
SP  - 2118
TI  - Comparing acute and chronic human cutaneous leishmaniasis caused by Leishmania major and Leishmania tropica focusing on arginase activity.
T2  - Journal of the European Academy of Dermatology and Venereology
UR  - http://dx.doi.org/10.1111/jdv.13838
UR  - http://hdl.handle.net/10044/1/64125
VL  - 30
ER  -
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