Imperial College London
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DrIngridMuller

Faculty of Medicine, Department of Infectious Disease

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120Wright Fleming WingSt Mary's Campus

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Publications

Citation

BibTex format

@article{Yizengaw:2016:10.3389/fimmu.2016.00517,
author = {Yizengaw, E and Getahun, M and Tajebe, F and Cruz, Cervera E and Adem, E and Mesfin, G and Hailu, A and Van, der Auwera G and Yardley, V and Lemma, M and Skhedy, Z and Diro, E and Yeshanew, A and Melkamu, R and Mengesha, B and Modolell, M and Munder, M and Muller, I and Takele, Y and Kropf, P},
doi = {10.3389/fimmu.2016.00517},
journal = {Frontiers in Immunology},
title = {Visceral leishmaniasis patients display altered composition and maturity of neutrophils as well as impaired neutrophil effector functions},
url = {http://dx.doi.org/10.3389/fimmu.2016.00517},
volume = {7},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Immunologically, active visceral leishmaniasis (VL) is characterised by profound immunosuppression, severe systemic inflammatoryresponses and an impaired capacity to control parasite replication.  Neutrophils are highly versatile cells, which play a crucial rolein the induction as well as the resolution of inflammation, the control of pathogen replication and the regulation of immuneresponses.  Neutrophil functions have been investigated in human cutaneous leishmaniasis, however, their role in human visceralleishmaniasis is poorly understood.In the present study we evaluated the activation status and effector functions of neutrophils in patients with active VL and aftersuccessful anti-leishmanial treatment.  Our results show that neutrophils are highly activated and have degranulated; high levels ofarginase, myeloperoxidase and elastase, all contained in neutrophils’ granules, were found in the plasma of VL patients.  Inaddition, we show that a large proportion of these cells are immature. We also analysed effector functions of neutrophils that areessential for pathogen clearance and show that neutrophils have an impaired capacity to release neutrophil extracellular traps,produce reactive oxygen species and phagocytose bacterial particles, but not Leishmania parasites.Our results suggest that impaired effector functions, increased activation and immaturity of neutrophils play a key role in thepathogenesis of VL.
AU  - Yizengaw,E
AU  - Getahun,M
AU  - Tajebe,F
AU  - Cruz,Cervera E
AU  - Adem,E
AU  - Mesfin,G
AU  - Hailu,A
AU  - Van,der Auwera G
AU  - Yardley,V
AU  - Lemma,M
AU  - Skhedy,Z
AU  - Diro,E
AU  - Yeshanew,A
AU  - Melkamu,R
AU  - Mengesha,B
AU  - Modolell,M
AU  - Munder,M
AU  - Muller,I
AU  - Takele,Y
AU  - Kropf,P
DO  - 10.3389/fimmu.2016.00517
PY  - 2016///
SN  - 1664-3224
TI  - Visceral leishmaniasis patients display altered composition and maturity of neutrophils as well as impaired neutrophil effector functions
T2  - Frontiers in Immunology
UR  - http://dx.doi.org/10.3389/fimmu.2016.00517
UR  - http://hdl.handle.net/10044/1/42604
VL  - 7
ER  -
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