Summary
Ioanna is a pharmaceutical scientist developing biomaterials for the administration of genes, cells and small molecules. She is a UKRI Future Leader Fellow and heads the preclinical R&D team of Sixfold Bioscience, a London-based biotech that develops RNA delivery systems. Ioanna is also an Honorary Research Fellow at the Department of Chemical Engineering at Imperial College London and member of the Strategic Advisory Board at the Royce Institute of Advanced Materials.
Ioanna is currently developing formulations for therapeutic RNA delivery.
Throughout her career she developed stem cell delivery formulations for regenerative therapies, silicon-based biomaterials, bioreducible polymeric nanoparticles, exosomes for the intracellular delivery of gene therapies and transfection of T-cells for CAR T-cell therapies. During her PhD at the University of Geneva (CH), she developed depot sustained release systems. Ioanna’s career pathway was always marked by translational horizons. In 2018, she co-founded Experoment Ltd, securing Letters of Intent of total value of £500k/p.a and establishing the business case for cloud-based synthetic biology. In 2012-2017, she worked with Aptissen S.A. (CH) on the production, scaling and regulatory concerns involved in the entry of a pharmaceutical product to the market.
Ioanna's work featured in the cover story of the Journal of Controlled Release and was recognized for the significance of its conclusions, in the drug delivery systems design. She has also published at Biomaterials and International Journal of Pharmaceutics. Full list of publications available here.
Publications
Journals
Ahadian S, Finbloom JA, Mofidfar M, et al., 2020, Micro and nanoscale technologies in oral drug delivery, Advanced Drug Delivery Reviews, Vol:157, ISSN:0169-409X, Pages:37-62
Mylonaki I, Allemann E, Delie F, et al., 2018, Imaging the porous structure in the core of degrading PLGA microparticles: The effect of molecular weight, Journal of Controlled Release, Vol:286, ISSN:0168-3659, Pages:231-239
Conference
Mylonaki I, Hachim D, Stuckey D, et al., 2020, Stem cell viability and proliferation is maintained in vivo using an alginate patch designed for epicardial administration, ELSEVIER SCI LTD, Pages:S205-S205, ISSN:1465-3249
Brito L, Mylonaki I, Moroz E, et al., 2019, Epicardial cell transfection with cationic polymeric nanocomplexes, British-Society-for-Gene-and-Cell-Therapy Autumn Conference, MARY ANN LIEBERT, INC, Pages:A9-A9, ISSN:1043-0342
Mylonaki I, Amoli MS, Brito L, et al., 2019, Intracellular siRNA delivery using silicon nanoneedle arrays, British-Society-for-Gene-and-Cell-Therapy Autumn Conference, MARY ANN LIEBERT, INC, Pages:A7-A7, ISSN:1043-0342