Publications
11 results found
Ahadian S, Finbloom JA, Mofidfar M, et al., 2020, Micro and nanoscale technologies in oral drug delivery, Advanced Drug Delivery Reviews, Vol: 157, Pages: 37-62, ISSN: 0169-409X
Oral administration is a pillar of the pharmaceutical industry and yet it remains challenging to administer hydrophilic therapeutics by the oral route. Smart and controlled oral drug delivery could bypass the physiological barriers that limit the oral delivery of these therapeutics. Micro- and nanoscale technologies, with an unprecedented ability to create, control, and measure micro- or nanoenvironments, have found tremendous applications in biology and medicine. In particular, significant advances have been made in using these technologies for oral drug delivery. In this review, we briefly describe biological barriers to oral drug delivery and micro and nanoscale fabrication technologies. Micro and nanoscale drug carriers fabricated using these technologies, including bioadhesives, microparticles, micropatches, and nanoparticles, are described. Other applications of micro and nanoscale technologies are discussed, including the fabrication of devices and tissue engineering models to precisely control or assess oral drug delivery in vivo and in vitro, respectively. Strategies to advance translation of micro and nanotechnologies into clinical trials for oral drug delivery are mentioned. Finally, challenges and future prospects on further integration of micro and nanoscale technologies with oral drug delivery systems are highlighted.
Mylonaki I, Hachim D, Stuckey D, et al., 2020, Stem cell viability and proliferation is maintained in vivo using an alginate patch designed for epicardial administration, Publisher: ELSEVIER SCI LTD, Pages: S205-S205, ISSN: 1465-3249
Brito L, Mylonaki I, Moroz E, et al., 2019, Epicardial cell transfection with cationic polymeric nanocomplexes, British-Society-for-Gene-and-Cell-Therapy Autumn Conference, Publisher: MARY ANN LIEBERT, INC, Pages: A9-A9, ISSN: 1043-0342
Paracrine signalling has been shown to contribute to heart regeneration after myocardial infarction (MI). As an important signalling regulatory centre, the epicardium is crucial for the heart development. Moreover, it is re-activated after MI, indicating its involvement in the response to this injury. This project aims to accomplish in situ transfection of the epicardium to stimulate the regenerative signalling pathways after MI.Here an in vitro proof of concept of epicardial cell transfection with nanocomplexes is presented. pABOL polyplexes, resulting from complexation of a bioreducible polymer with a GFP gene plasmid (pCAG-GFP), were able to transfect epicardial cells when added in suspension to the culture. The pCAG-GFP-pABOL polyplexes formulation was the most suitable when compared to Lipofectamine, Fugene or naked plasmid, revealing 45.9±9.7% of cell viability and 39.4±6.4% of transfection efficiency. Moreover, the freeze-drying of the pABOL polyplexes was tested. pABOL polyplexes formed in water and in the different sugar/surfactants HEPES buffers. The ζ-potential of these polyplexes ranged between +20 and +30mV. After the freeze-drying, pABOL polyplexes only maintained their transfection activity when formed in sugar-containing buffers.These preliminary results indicate for the first time the advantage of using pABOL polymer in comparison with standard transfection reagents for epicardial cells transfection and the possibility of retaining transfection activity of pABOL polyplexes when freeze-dried. Our final aim is to use nanoneedles, which can transfer substances to the epicardial layer alone, to deliver these polyplexes.
Mylonaki I, Amoli MS, Brito L, et al., 2019, Intracellular siRNA delivery using silicon nanoneedle arrays, British-Society-for-Gene-and-Cell-Therapy Autumn Conference, Publisher: MARY ANN LIEBERT, INC, Pages: A7-A7, ISSN: 1043-0342
Mylonaki I, Allemann E, Delie F, et al., 2018, Imaging the porous structure in the core of degrading PLGA microparticles: The effect of molecular weight, JOURNAL OF CONTROLLED RELEASE, Vol: 286, Pages: 231-239, ISSN: 0168-3659
- Author Web Link
- Cite
- Citations: 38
Mylonaki I, Allain E, Strano F, et al., 2018, Evaluating intimal hyperplasia under clinical conditions, INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY, Vol: 27, Pages: 427-436, ISSN: 1569-9293
- Author Web Link
- Cite
- Citations: 10
Mylonaki I, Trosi O, Allemann E, et al., 2018, Design and characterization of a perivascular PLGA coated PET mesh sustaining the release of atorvastatin for the prevention of intimal hyperplasia, INTERNATIONAL JOURNAL OF PHARMACEUTICS, Vol: 537, Pages: 40-47, ISSN: 0378-5173
- Author Web Link
- Cite
- Citations: 7
Mylonaki I, Allemann E, Saucy F, et al., 2017, Perivascular medical devices and drug delivery systems: Making the right choices, BIOMATERIALS, Vol: 128, Pages: 56-68, ISSN: 0142-9612
- Author Web Link
- Cite
- Citations: 20
Mylonaki I, Strano F, Deglise S, et al., 2016, Perivascular sustained release of atorvastatin from a hydrogel-microparticle delivery system decreases intimal hyperplasia, JOURNAL OF CONTROLLED RELEASE, Vol: 232, Pages: 93-102, ISSN: 0168-3659
- Author Web Link
- Cite
- Citations: 26
Dubuis C, May L, Alonso F, et al., 2013, Atorvastatin-Loaded Hydrogel Affects the Smooth Muscle Cells of Human Veins, JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, Vol: 347, Pages: 574-581, ISSN: 0022-3565
- Author Web Link
- Cite
- Citations: 22
Milonaki Y, Kaditi E, Pispas S, et al., 2012, Amphiphilic gradient copolymers of 2-methyl- and 2-phenyl-2-oxazoline: self-organization in aqueous media and drug encapsulation, JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY, Vol: 50, Pages: 1226-1237, ISSN: 0887-624X
- Author Web Link
- Cite
- Citations: 70
This data is extracted from the Web of Science and reproduced under a licence from Thomson Reuters. You may not copy or re-distribute this data in whole or in part without the written consent of the Science business of Thomson Reuters.