Publications
239 results found
White JPM, Calcott G, Jenes A, et al., 2011, Xenon reduces activation of transient receptor potential vanilloid type 1 (TRPV1) in rat dorsal root ganglion cells and in human TRPV1-expressing HEK293 cells, LIFE SCIENCES, Vol: 88, Pages: 141-149, ISSN: 0024-3205
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- Citations: 5
White JPM, Cibelli M, Fidalgo AR, et al., 2011, Extracellular signal-regulated kinases in pain of peripheral origin, EUROPEAN JOURNAL OF PHARMACOLOGY, Vol: 650, Pages: 8-17, ISSN: 0014-2999
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- Citations: 14
Urban L, White JPM, Nagy I, 2011, Molecular Structure of Transient Receptor Potential Vanilloid Type 1 Ion Channel (TRPV1), CURRENT PHARMACEUTICAL BIOTECHNOLOGY, Vol: 12, Pages: 115-121, ISSN: 1389-2010
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- Citations: 6
White JPM, Urban L, Nagy I, 2011, TRPV1 Function in Health and Disease, CURRENT PHARMACEUTICAL BIOTECHNOLOGY, Vol: 12, Pages: 130-144, ISSN: 1389-2010
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- Citations: 42
Nagy I, 2011, Could anandamide be involved in activating TRPV1 in nociceptive primary sensory neurons?, Annual Meeting of the European Winter Conference on Brain Research
Nagy I, 2011, Effects of the endogenous agent anandamide on nociceptive primary sensory neurons, Congress of the Polish Neuroscience Society
Nagy I, 2011, Endovanilloids of primary sensory neurons origin, synthesis and effects on neuronal activity and excitability, Congress of The European Federation of IASP Chapters
Valente J, Tailor H, Jenes A, et al., 2011, Expression of N-acyl phosphotidylethanolamine phospholipase D in rat dorsal root ganglion neurons., Meeting of the Physiological Society
Mlynarczyk M, Nagy I, 2010, Characterisation of <i>n</i>-arachidonoylethanolamine (Anandamide)-induced transient receptor potential vanilloid type 1 ion channel (TRPV1)-mediated responses in rat cultured Primary Sensory Neurons (PSN), ACTA PHYSIOLOGICA HUNGARICA, Vol: 97, Pages: 461-461, ISSN: 0231-424X
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- Citations: 1
Nagy I, 2010, TRPV1, CB1 and anandamide: curious relationships, ACTA PHYSIOLOGICA HUNGARICA, Vol: 97, Pages: 464-464, ISSN: 0231-424X
Nagy I, Tailor H, Valente J, 2010, ANANDAMIDE, CB1 AND TRPV1 HOT RELATIONSHIPS, 7th Joint Meeting of the European Neuropeptide Club and the American-Summer-Neuropeptide Conference, Publisher: CHURCHILL LIVINGSTONE, Pages: 523-524, ISSN: 0143-4179
Valente J, Jenes A, Avelino A, et al., 2010, IMMUNOHISTOCHEMICAL DESCRIPTION OF N-ACYL PHOSPHOTIDYLETHANOLAMINE PHOSPHOLIPASE D (NAPE-PLD) IN RAT DORSAL ROOT GANGLION NEURONS, 7th Joint Meeting of the European Neuropeptide Club and the American-Summer-Neuropeptide Conference, Publisher: CHURCHILL LIVINGSTONE, Pages: 523-523, ISSN: 0143-4179
Nagy I, 2010, The effect of altered body temperature on the nervous electrical activity in anesthetized rats, ACTA PHYSIOLOGICA HUNGARICA, Vol: 97, Pages: 464-465, ISSN: 0231-424X
Jenes A, Yan R, Buluwela L, et al., 2010, ANANDAMIDE SYNTHESIS IN PRIMARY SENSORY NEURONS, 7th Joint Meeting of the European Neuropeptide Club and the American-Summer-Neuropeptide Conference, Publisher: CHURCHILL LIVINGSTONE, Pages: 534-534, ISSN: 0143-4179
Soneji ND, Paule CC, Mlynarczyk M, et al., 2010, Effects of cannabinoids on capsaicin receptor activity following exposure of primary sensory neurons to inflammatory mediators, LIFE SCIENCES, Vol: 87, Pages: 162-168, ISSN: 0024-3205
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- Citations: 10
Santha P, Jenes A, Somogyi C, et al., 2010, The endogenous cannabinoid anandamide inhibits transient receptor potential vanilloid type 1 receptor-mediated currents in rat cultured primary sensory neurons, ACTA PHYSIOLOGICA HUNGARICA, Vol: 97, Pages: 149-158, ISSN: 0231-424X
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- Citations: 25
White JPM, Cibelli M, Fidalgo AR, et al., 2010, SENSITIZATION OF THE TRANSIENT RECEPTOR POTENTIAL VANILLOID TYPE 1 ION CHANNEL BY ISOFLURANE OR SEVOFLURANE DOES NOT RESULT IN EXTRACELLULAR SIGNAL-REGULATED KINASE 1/2 ACTIVATION IN RAT SPINAL DORSAL HORN NEURONS, NEUROSCIENCE, Vol: 166, Pages: 633-638, ISSN: 0306-4522
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- Citations: 1
White JPM, Cibelli M, Fidalgo AR, et al., 2010, Role of Transient Receptor Potential and Acid-sensing Ion Channels in Peripheral Inflammatory Pain, ANESTHESIOLOGY, Vol: 112, Pages: 729-741, ISSN: 0003-3022
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- Citations: 30
Charrua A, Reguenga C, Cordeiro JM, et al., 2009, Functional Transient Receptor Potential Vanilloid 1 is Expressed in Human Urothelial Cells, JOURNAL OF UROLOGY, Vol: 182, Pages: 2944-2950, ISSN: 0022-5347
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- Citations: 48
Santha P, Tassi N, Oszlacz O, et al., 2009, PREFERENTIAL EXPRESSION OF INSULIN RECEPTOR IN VISCERAL DORSAL ROOT GANGLION NEURONS INNERVATING THE URINARY BLADDER, Joint Meeting of the European-Neuropeptides-Club/Summer Neuropeptides Conference, Publisher: CHURCHILL LIVINGSTONE, Pages: 428-428, ISSN: 0143-4179
Mahmud A, Santha P, Paule CC, et al., 2009, CANNABINOID 1 RECEPTOR ACTIVATION INHIBITS TRANSIENT RECEPTOR POTENTIAL VANILLOID TYPE 1 RECEPTOR-MEDIATED CATIONIC INFLUX INTO RAT CULTURED PRIMARY SENSORY NEURONS, NEUROSCIENCE, Vol: 162, Pages: 1202-1211, ISSN: 0306-4522
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- Citations: 39
Nagy B, Fedonidis C, Photiou A, et al., 2009, CAPSAICIN-SENSITIVE PRIMARY SENSORY NEURONS IN THE MOUSE EXPRESS <i>N</i>-Acyl PHOSPHATIDYLETHANOLAMINE PHOSPHOLIPASE D, NEUROSCIENCE, Vol: 161, Pages: 572-577, ISSN: 0306-4522
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- Citations: 12
Charrua A, Reguenga C, Paule CC, et al., 2009, Cystitis is Associated With TRPV1b-Downregulation in Rat Dorsa I Root Ganglia Comment, JOURNAL OF UROLOGY, Vol: 181, Pages: 2825-2825, ISSN: 0022-5347
Lever IJ, Robinson M, Cibelli M, et al., 2009, Localization of the Endocannabinoid-Degrading Enzyme Fatty Acid Amide Hydrolase in Rat Dorsal Root Ganglion Cells and Its Regulation after Peripheral Nerve Injury, J.Neurosci., Vol: 29, Pages: 3766-3780
Fatty acid amide hydrolase (FAAH) is a degradative enzyme for a group of endogenous signaling lipids that includes anandamide (AEA). AEA acts as an endocannabinoid and an endovanilloid by activating cannabinoid and vanilloid type 1 transient receptor potential (TRPV1) receptors, respectively, on dorsal root ganglion (DRG) sensory neurons. Inhibition of FAAH activity increases AEA concentrations in nervous tissue and reduces sensory hypersensitivity in animal pain models. Using immunohistochemistry, Western blotting, and reverse transcription-PCR, we demonstrate the location of the FAAH in adult rat DRG, sciatic nerve, and spinal cord. In naive rats, FAAH immunoreactivity localized to the soma of 32.7 {+/-} 0.8% of neurons in L4 and L5 DRG. These were small-sized (mean soma area, 395.96 {+/-} 5.6 {micro}m2) and predominantly colabeled with peripherin and isolectin B4 markers of unmyelinated C-fiber neurons; 68% colabeled with antibodies to TRPV1 (marker of nociceptive DRG neurons), and <2% colabeled with NF200 (marker of large myelinated neurons). FAAH-IR was also present in small, NF200-negative cultured rat DRG neurons. Incubation of these cultures with the FAAH inhibitor URB597 increased AEA-evoked cobalt uptake in a capsazepine-sensitive manner. After sciatic nerve axotomy, there was a rightward shift in the cell-size distribution of FAAH-immunoreactive (IR) DRG neurons ipsilateral to injury: FAAH immunoreactivity was detected in larger-sized cells that colabeled with NF200. An ipsilateral versus contralateral increase in both the size and proportion of FAAH-IR DRG occurred after spinal nerve transection injury but not after chronic inflammation of the rat hindpaw 2 d after injection of complete Freund's adjuvant. This study reveals the location of FAAH in neural tissue involved in peripheral nociceptive transmission
Nagy I, 2009, Interactions of the endocannabinoid and endovanilloid systems in primary sensory neurons., European Winter Conference on Brain Research
Nagy I, Fedonidis C, Paule CC, et al., 2009, NAPE-PLD is involved in anandamide synthesis in capsaicin-sensitive primary sensory neurons, IUPS World Congress
Nagy I, Paule CC, White JPM, 2009, Molecular mechanisms of TRPV1-mediated pain., Neuroimmune Biology, Editors: Berzi, Jancso, Amsterdam, Publisher: Elsevier, Pages: 75-99
Nagy I, Lever I, Cibelli M, 2009, Signalling through non-ionotropic and non-G protein-coupled receptors, Anesthetic Pharmacology, Editors: Evers, Maze, Kharasch
Charrua A, Reguenga C, Cordeiro JM, et al., 2009, O urotélio humano responde a mediadores inflamatórios através de mecanismos dependentes do TRPV1., Acta Urológica, Vol: 26
Paule CC, Davis JB, Nagy I, 2008, Human TRPV1 polymorphs show different sensitivity to various activators, Conference on Neuropeptide - Functions, Dysfunctions and Therapeutic Options
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