Imperial College London
Alternate

DrIstvanNagy

Faculty of Medicine, Department of Surgery & Cancer

Reader in Nociceptive Mechanisms
 
 
 
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Contact

 

+44 (0)20 3315 8897i.nagy Website

 
 
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Assistant

 

Miss Steffi Klier +44 (0)20 3315 8816

 
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Location

 

G345Chelsea and Westminster HospitalChelsea and Westminster Campus

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Summary

 

Publications

Citation

BibTex format

@article{Nagy:2021:10.1038/s41598-021-82829-6,
author = {Nagy, I and Li, T and Wang, T and Hu, V and Saad, D and Sousa-Valente, J and La, Montanara P},
doi = {10.1038/s41598-021-82829-6},
journal = {Scientific Reports},
title = {TRPV1 feed-forward sensitisation depends on COX2 upregulation in primary sensory neurons},
url = {http://dx.doi.org/10.1038/s41598-021-82829-6},
volume = {11},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Increased activity and excitability (sensitisation) of a series of molecules including the transient receptor potential ion channel, vanilloid subfamily, member 1 (TRPV1) in pain-sensing (nociceptive) primary sensory neurons are pivotal for developing pathological pain experiences in tissue injuries. TRPV1 sensitisation is induced and maintained by two major mechanisms; post-translational and transcriptional changes in TRPV1 induced by inflammatory mediators produced and accumulated in injured tissues, and TRPV1 activation-induced feed-forward signalling. The latter mechanism includes synthesis of TRPV1 agonists within minutes, and upregulation of various receptors functionally linked to TRPV1 within a few hours, in nociceptive primary sensory neurons. Here, we report that a novel mechanism, which contributes to TRPV1 activation-induced TRPV1-sensitisation within ~ 30 min in at least ~ 30% of TRPV1-expressing cultured murine primary sensory neurons, is mediated through upregulation in cyclooxygenase 2 (COX2) expression and increased synthesis of a series of COX2 products. These findings highlight the importance of feed-forward signalling in sensitisation, and the value of inhibiting COX2 activity to control pain, in nociceptive primary sensory neurons in tissue injuries.
AU  - Nagy,I
AU  - Li,T
AU  - Wang,T
AU  - Hu,V
AU  - Saad,D
AU  - Sousa-Valente,J
AU  - La,Montanara P
DO  - 10.1038/s41598-021-82829-6
PY  - 2021///
SN  - 2045-2322
TI  - TRPV1 feed-forward sensitisation depends on COX2 upregulation in primary sensory neurons
T2  - Scientific Reports
UR  - http://dx.doi.org/10.1038/s41598-021-82829-6
UR  - http://hdl.handle.net/10044/1/86949
VL  - 11
ER  -
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