Imperial College London
Alternate

DrIstvanNagy

Faculty of Medicine, Department of Surgery & Cancer

Reader in Nociceptive Mechanisms
 
 
 
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Contact

 

+44 (0)20 3315 8897i.nagy Website

 
 
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Assistant

 

Miss Steffi Klier +44 (0)20 3315 8816

 
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Location

 

G345Chelsea and Westminster HospitalChelsea and Westminster Campus

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Summary

 

Publications

Citation

BibTex format

@article{White:2023:10.1007/112_2022_75,
author = {White, JPM and Cibelli, M and Nagy, I and Nilius, B and McGeown, JG},
doi = {10.1007/112_2022_75},
journal = {Rev Physiol Biochem Pharmacol},
pages = {57--93},
title = {The Emerging Pro-Algesic Profile of Transient Receptor Potential Vanilloid Type 4.},
url = {http://dx.doi.org/10.1007/112_2022_75},
volume = {186},
year = {2023}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Transient receptor potential vanilloid type 4 (TRPV4) channels are Ca2+-permeable non-selective cation channels which mediate a wide range of physiological functions and are activated and modulated by a diverse array of stimuli. One of this ion channel's least discussed functions is in relation to the generation and maintenance of certain pain sensations. However, in the two decades which have elapsed since the identification of this ion channel, considerable data has emerged concerning its function in mediating pain sensations. TRPV4 is a mediator of mechanical hyperalgesia in the various contexts in which a mechanical stimulus, comprising trauma (at the macro-level) or discrete extracellular pressure or stress (at the micro-level), results in pain. TRPV4 is also recognised as constituting an essential component in mediating inflammatory pain. It also plays a role in relation to many forms of neuropathic-type pain, where it functions in mediating mechanical allodynia and hyperalgesia.Here, we review the role of TRPV4 in mediating pain sensations.
AU  - White,JPM
AU  - Cibelli,M
AU  - Nagy,I
AU  - Nilius,B
AU  - McGeown,JG
DO  - 10.1007/112_2022_75
EP  - 93
PY  - 2023///
SN  - 0303-4240
SP  - 57
TI  - The Emerging Pro-Algesic Profile of Transient Receptor Potential Vanilloid Type 4.
T2  - Rev Physiol Biochem Pharmacol
UR  - http://dx.doi.org/10.1007/112_2022_75
UR  - https://www.ncbi.nlm.nih.gov/pubmed/36378366
VL  - 186
ER  -
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