Imperial College London
Alternate

DrIstvanNagy

Faculty of Medicine, Department of Surgery & Cancer

Reader in Nociceptive Mechanisms
 
 
 
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Contact

 

+44 (0)20 3315 8897i.nagy Website

 
 
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Assistant

 

Miss Steffi Klier +44 (0)20 3315 8816

 
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Location

 

G345Chelsea and Westminster HospitalChelsea and Westminster Campus

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Summary

 

Publications

Citation

BibTex format

@article{Torres-Perez:2017:10.1038/srep41221,
author = {Torres-Perez, JV and Santha, P and Varga, A and Szucs, P and Sousa-Valante, J and Gaal, B and Sivado, M and Andreou, A and Beattie, S and Nagy, B and Matesz, K and Arthur, JSC and Jancso, G and Nagy, I},
doi = {10.1038/srep41221},
journal = {Scientific Reports},
title = {Phosphorylated histone 3 at serine 10 identifies activated spinal neurons and contributes to the development of tissue injury-associated pain},
url = {http://dx.doi.org/10.1038/srep41221},
volume = {7},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Transcriptional changes in superficial spinal dorsal horn neurons (SSDHN) are essential in the development and maintenance of prolonged pain. Epigenetic mechanisms including post-translational modifications in histones are pivotal in regulating transcription. Here, we report that phosphorylation of serine 10 (S10) in histone 3 (H3) specifically occurs in a group of rat SSDHN following the activation of nociceptive primary sensory neurons by burn injury, capsaicin application or sustained electrical activation of nociceptive primary sensory nerve fibres. In contrast, brief thermal or mechanical nociceptive stimuli, which fail to induce tissue injury or inflammation, do not produce the same effect. Blocking N-methyl-D-aspartate receptors or activation of extracellular signal-regulated kinases 1 and 2, or blocking or deleting the mitogen- and stress-activated kinases 1 and 2 (MSK1/2), which phosphorylate S10 in H3, inhibit up-regulation in phosphorylated S10 in H3 (p-S10H3) as well as fos transcription, a down-stream effect of p-S10H3. Deleting MSK1/2 also inhibits the development of carrageenan-induced inflammatory heat hyperalgesia in mice. We propose that p-S10H3 is a novel marker for nociceptive processing in SSDHN with high relevance to transcriptional changes and the development of prolonged pain.
AU  - Torres-Perez,JV
AU  - Santha,P
AU  - Varga,A
AU  - Szucs,P
AU  - Sousa-Valante,J
AU  - Gaal,B
AU  - Sivado,M
AU  - Andreou,A
AU  - Beattie,S
AU  - Nagy,B
AU  - Matesz,K
AU  - Arthur,JSC
AU  - Jancso,G
AU  - Nagy,I
DO  - 10.1038/srep41221
PY  - 2017///
SN  - 2045-2322
TI  - Phosphorylated histone 3 at serine 10 identifies activated spinal neurons and contributes to the development of tissue injury-associated pain
T2  - Scientific Reports
UR  - http://dx.doi.org/10.1038/srep41221
UR  - http://hdl.handle.net/10044/1/43234
VL  - 7
ER  -
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