Imperial College London
Alternate

DrIsabelleSalles

Faculty of Medicine, Department of Immunology and Inflammation

Honorary Lecturer
 
 
 
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Contact

 

+44 (0)20 3313 2298i.salles

 
 
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Location

 

5S5Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Publication Type
Year
to

60 results found

Salles II, Crawley JTB, 2012, Blocking VWF platelet binding to treat TTP, BLOOD, Vol: 120, Pages: 3390-3392, ISSN: 0006-4971

Journal article

Burdorf L, Zhang T, Rybak E, Salles II, Broos K, Welty E, Avon C, Laaris A, Cheng X, Ayares D, Deckmyn H, Azimzadeh AM, Pierson RNet al., 2012, Combined aGPIb and aGPIIb/IIIa Blockade Prevents Platelet Sequestration in a Pig-to-Human Lung Perfusion Model, 32nd Annual Meeting and Scientific Sessions of the International-Society-for-Heart-and-Lung-Transplantation/Meeting of the ISHLT Academy - Core Competencies in Mechanical Circulatory Support, Publisher: ELSEVIER SCIENCE INC, Pages: S106-S106, ISSN: 1053-2498

Conference paper

Heger M, Salles II, Bezemer R, Cloos MA, Mordon SR, Begu S, Deckmyn H, Beek JFet al., 2011, Laser-induced primary and secondary hemostasis dynamics and mechanisms in relation to selective photothermolysis of port wine stains, JOURNAL OF DERMATOLOGICAL SCIENCE, Vol: 63, Pages: 139-147, ISSN: 0923-1811

Journal article

Thijs T, Broos K, Salles II, Soenen S, Vandenbulcke A, Lopez JA, Vanhoorelbeke K, Deckmyn Het al., 2011, Towards platelet-specific RNA interference, JOURNAL OF THROMBOSIS AND HAEMOSTASIS, Vol: 9, Pages: 710-710, ISSN: 1538-7933

Journal article

Burdorf L, Barth RN, Zhang T, Rybak E, Salles II, Broos K, Welty E, Avon C, Laaris A, McCormick B, Ayares D, Dickmyn H, Azimzadeh AM, Pierson RNet al., 2011, Targeting GPIb-vWF Axis by Anti-GPIb Fab Reduces Platelet Sequestration in an <i>Ex Vivo</i> Xenogeneic Pig Liver Perfusion Model, American Transplant Congress, Publisher: WILEY-BLACKWELL, Pages: 108-108, ISSN: 1600-6135

Conference paper

Salles II, O'Connor MN, Thijssen-Timmer DC, Broos K, Deckmyn Het al., 2011, PLATELET FUNCTIONAL GENOMICS, PLATELET PROTEOMICS: PRINCIPLES, ANALYSIS, AND APPLICATIONS, Editors: Garcia, Senis, Publisher: JOHN WILEY & SONS INC, Pages: 253-284, ISBN: 978-0-470-46337-6

Book chapter

Goodall AH, Burns P, Salles I, Macaulay IC, Jones CI, Ardissino D, de Bono B, Bray SL, Deckmyn H, Dudbridge F, Fitzgerald DJ, Garner SF, Gusnanto A, Koch K, Langford C, O'Connor MN, Rice CM, Stemple D, Stephens J, Trip MD, Zwaginga J-J, Samani NJ, Watkins NA, Maguire PB, Ouwehand WHet al., 2010, Transcription profiling in human platelets reveals LRRFIP1 as a novel protein regulating platelet function, BLOOD, Vol: 116, Pages: 4646-4656, ISSN: 0006-4971

Journal article

Salles II, Broos K, Fontayne A, Szanto T, Ruan C, Nurden AT, Vanhoorelbeke K, Deckmyn Het al., 2010, Development of a high-throughput ELISA assay for platelet function testing using platelet-rich plasma or whole blood, THROMBOSIS AND HAEMOSTASIS, Vol: 104, Pages: 392-401, ISSN: 0340-6245

Journal article

Salles II, Thijs T, Brunaud C, De Meyer SF, Thys J, Vanhoorelbeke K, Deckmyn Het al., 2009, Human platelets produced in nonobese diabetic/severe combined immunodeficient (NOD/SCID) mice upon transplantation of human cord blood CD34<SUP>+</SUP> cells are functionally active in an ex vivo flow model of thrombosis, BLOOD, Vol: 114, Pages: 5044-5051, ISSN: 0006-4971

Journal article

Deckmyn H, Salles II, Pierson RN, Azimzadeh AMet al., 2009, Humanized monoclonal antibody 6B4 Fab inhibits GP1B-vWF-mediated human platelet aggregation by porcine plasma, Joint Meeting of the International-Pancreas-and-Islet-Transplant-Association/International-Xenotransplantation-Association, Publisher: WILEY-BLACKWELL PUBLISHING, INC, Pages: 370-370, ISSN: 0908-665X

Conference paper

Heger M, Salles II, van Vuure W, Deckmyn H, Beek JFet al., 2009, Fluorescent Labeling of Platelets with Polyanionic Fluorescein Derivatives, ANALYTICAL AND QUANTITATIVE CYTOLOGY AND HISTOLOGY, Vol: 31, Pages: 227-232, ISSN: 0884-6812

Journal article

Peeters K, Salles II, Hoylaerts MF, Deckmyn H, Van Geet C, Freson Ket al., 2009, Thrombopoietic effect of VPAC1 inhibition in murine and human thrombopoiesis, Publisher: ELSEVIER SCIENCE INC, Pages: 653-654, ISSN: 1538-7933

Conference paper

Salles II, Thijs T, Brunaud C, De Meyer SF, Thys J, Vanhoorelbeke K, Deckmyn Het al., 2009, Human platelets produced in NOD/SCID mice upon transplantation of human cord blood CD34+cells are functionally active in an ex vivo flow model of thrombosis, Publisher: ELSEVIER SCIENCE INC, Pages: 653-653, ISSN: 1538-7933

Conference paper

Salles II, O'Connor MN, Cvejic A, Watkins NA, Burns P, Walker A, Garner SF, Jones C, Macaulay IC, Steward M, Zwaginga J, Bray SL, Dudbridge F, de Bono B, Goodall AH, Deckmyn H, Stemple DL, Ouwehand WHet al., 2009, Defining the function of novel platelet genes using a laser thrombosis model in danio rerio, Publisher: ELSEVIER SCIENCE INC, Pages: 18-18, ISSN: 1538-7933

Conference paper

Heger M, Salles II, van Vuure W, Hamelers IHL, de Kroon AIPM, Deckmyn H, Beek JFet al., 2009, On the interaction of fluorophore-encapsulating PEGylated lecithin liposomes with hamster and human platelets, MICROVASCULAR RESEARCH, Vol: 78, Pages: 57-66, ISSN: 0026-2862

Journal article

Heger M, de Kroon AIPM, Salles II, Deckmyn Het al., 2009, Platelets and PEGylated lecithin liposomes: When stealth is allegedly picked up on the radar (and eaten), MICROVASCULAR RESEARCH, Vol: 78, Pages: 1-3, ISSN: 0026-2862

Journal article

O'Connor MN, Salles II, Cvejic A, Watkins NA, Walker A, Garner SF, Jones CI, Macaulay IC, Steward M, Zwaginga J-J, Bray SL, Dudbridge F, de Bono B, Goodall AH, Deckmyn H, Stemple DL, Ouwehand WHet al., 2009, Functional genomics in zebrafish permits rapid characterization of novel platelet membrane proteins, BLOOD, Vol: 113, Pages: 4754-4762, ISSN: 0006-4971

Journal article

Salles II, O'Connor MN, Watkins NA, Walker A, Garner SF, Jones CI, Macauley I, Steward M, Zwaginga JJ, Bray SL, Cvejic A, Dudbridge F, de Bono B, Deckmyn H, Stemple DL, Ouwehand Wet al., 2008, Functional Genomics in Zebrafish Permits Rapid Characterization of Novel Platelet Membrane Proteins., 50th Annual Meeting of the American-Society-of-Hematology, Publisher: AMER SOC HEMATOLOGY, Pages: 987-987, ISSN: 0006-4971

Conference paper

De Meyer SF, Vanhoorelbeke K, Broos K, Salles II, Deckmyn Het al., 2008, Antiplatelet drugs, BRITISH JOURNAL OF HAEMATOLOGY, Vol: 142, Pages: 515-528, ISSN: 0007-1048

Journal article

Salles II, Feys HB, Iserbyt BF, De Meyer SF, Vanhoorelbeke K, Deckmyn Het al., 2008, Inherited traits affecting platelet function, BLOOD REVIEWS, Vol: 22, Pages: 155-172, ISSN: 0268-960X

Journal article

Szanto T, Schlammadinger A, Salles I, Pareyn I, Vauterin S, Harsfalvi J, Vanden Bulcke A-M, Deckmyn H, Vanhoorelbeke Ket al., 2007, Type 2B von Willebrand disease in seven individuals from three different families:: Phenotypic and genotypic characterization, THROMBOSIS AND HAEMOSTASIS, Vol: 98, Pages: 251-254, ISSN: 0340-6245

Journal article

De Meyer SF, Vanhoorelbeke K, Ulrichts H, Staelens S, Feys HB, Salles I, Fontayne A, Deckmyn Het al., 2006, Development of monoclonal antibodies that inhibit platelet adhesion or aggregation as potential anti-thrombotic drugs., Cardiovasc Hematol Disord Drug Targets, Vol: 6, Pages: 191-207, ISSN: 1871-529X

Cardiovascular disease is the major cause of mortality in Western countries. Platelets play a crucial role in the development of arterial thrombosis and other pathophysiologies leading to clinical ischemic events. In the damaged vessel wall, platelets adhere to the subendothelium through an interaction with von Willebrand factor (VWF), which forms a bridge between subendothelial collagen and the platelet receptor glycoprotein (GP) Ib/IX/V. This reversible adhesion allows platelets to roll over the damaged area, decreasing their velocity and resulting in strong platelet activation. This leads to the conformational activation of the platelet GPIIb/IIIa receptor, fibrinogen binding and finally to platelet aggregation. As each interaction (collagen-VWF, VWF-GPIb and GPIIb/IIIa-fibrinogen) plays an essential role in primary haemostasis, loss of either of these interactions results in a bleeding diathesis, implying that interfering with these interactions might result in an anti-thrombotic effect. Whereas GPIIb/IIIa antagonists indeed are effective anti-thrombotics, it has been suggested that drugs which block the initial steps of thrombus formation (collagen-VWF or VWF-GPIb interaction) might have advantages over the ones that merely inhibit platelet aggregation. In this review we will discuss and compare the development of monoclonal antibodies (moAbs) that inhibit platelet adhesion or platelet aggregation. The effect of the moAbs in in vitro experiments, in in vivo models and in clinical trials will be described. Benefits, limitations, current applications and the future perspectives in the development of antibodies for each target will be discussed.

Journal article

Salles II, Voth DE, Ward SC, Averette KM, Tweten RK, Bradley KA, Ballard JDet al., 2006, Cytotoxic activity of <i>Bacillus anthracis</i> protective antigen observed in a macrophage cell line overexpressing ANTXR1, CELLULAR MICROBIOLOGY, Vol: 8, Pages: 1272-1281, ISSN: 1462-5814

Journal article

Heger M, Salles II, Bezemer R, Mordon S, Begu S, Jouy N, Deckmyn H, van Gemert MJC, Beek JFet al., 2006, Thrombosis as an integral part of endovascular laser-tissue interactions, 26th Annual Meeting of the American-Society-for-Laser-Medicine-and-Surgery, Publisher: WILEY-LISS, Pages: 5-5, ISSN: 0196-8092

Conference paper

Voth DE, Hamm EE, Nguyen LG, Tucker AE, Salles II, Ortiz-Leduc W, Ballard JDet al., 2005, Bacillus anthracis oedema toxin as a cause of tissue necrosis and cell type-specific cytotoxicity., Cell Microbiol, Vol: 7, Pages: 1139-1149, ISSN: 1462-5814

Oedema factor (OF) and protective antigen (PA) are secreted by Bacillus anthracis, and their binary combination yields oedema toxin (OT). Following PA-mediated delivery to the cytosol, OF functions as an adenylate cyclase generating high levels of cAMP. To assess OT as a possible cause of tissue damage and cell death, a novel approach was developed, which utilized a developing zebrafish embryo model to study toxin activity. Zebrafish embryos incubated with OT exhibited marked necrosis of the liver, cranium and gastrointestinal tract, as well as reduced swim bladder inflation. The OT-treated embryos survived after all stages of development but succumbed to the toxin within 7 days. Additional analysis of specific cell lines, including macrophage and non-macrophage, showed OT-induced cell death is cell type-specific. There was no discernible correlation between levels of OF-generated cAMP and cell death. Depending on the type of cell analysed, cell death could be detected in low levels of cAMP, and, conversely, cell survival was observed in one cell line in which high levels of cAMP were found following treatment with OT. Collectively, these data suggest OT is cytotoxic in a cell-dependent manner and may contribute to disease through direct cell killing leading to tissue necrosis.

Journal article

Voth DE, Hamm EE, Nguyen LG, Tucker AE, Salles II, Ortiz-Leduc W, Ballard JDet al., 2005, <i>Bacillus anthracis</i> oedema toxin as a cause of tissue necrosis and cell type-specific cytotoxicity, CELLULAR MICROBIOLOGY, Vol: 7, Pages: 1139-1149, ISSN: 1462-5814

Journal article

Salles II, Tucker AE, Voth DE, Ballard JDet al., 2003, Toxin-induced resistance in <i>Bacillus anthracis</i> lethal toxin-treated macrophages, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 100, Pages: 12426-12431, ISSN: 0027-8424

Journal article

Tucker AE, Salles II, Voth DE, Ortiz-Leduc W, Wang H, Dozmorov I, Centola M, Ballard JDet al., 2003, Decreased glycogen synthase kinase 3-beta levels and related physiological changes in <i>Bacillus anthracis</i> lethal toxin-treated macrophages, CELLULAR MICROBIOLOGY, Vol: 5, Pages: 523-532, ISSN: 1462-5814

Journal article

Salles I, 2002, Phytoalexin induction and β-1,3-glucanase activities in Colletotrichum trifolii infected leaves of alfalfa (Medicago sativa L.), Physiological and Molecular Plant Pathology, Vol: 61, Pages: 89-101, ISSN: 0885-5765

Journal article

Salles II, Blount JW, Dixon RA, Schubert Ket al., 2002, Phytoalexin induction and β-1,3-glucanase activities in <i>Colletotrichum trifolii</i> infected leaves of alfalfa (<i>Medicago sativa</i> L.), PHYSIOLOGICAL AND MOLECULAR PLANT PATHOLOGY, Vol: 61, Pages: 89-101, ISSN: 0885-5765

Journal article

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