Publications
565 results found
Geenen S, du Preez FB, Reed M, et al., 2012, A mathematical modelling approach to assessing the reliability of biomarkers of glutathione metabolism, EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, Vol: 46, Pages: 233-243, ISSN: 0928-0987
- Author Web Link
- Cite
- Citations: 18
Schulz-Utermoehl T, Sarda S, Foster JR, et al., 2012, Evaluation of the pharmacokinetics, biotransformation and hepatic transporter effects of troglitazone in mice with humanized livers, XENOBIOTICA, Vol: 42, Pages: 503-517, ISSN: 0049-8254
- Author Web Link
- Cite
- Citations: 27
Brown LJ, Smith RW, Toutoungi DE, et al., 2012, Enhanced Analyte Detection Using In-Source Fragmentation of Field Asymmetric Waveform Ion Mobility Spectrometry-Selected Ions in Combination with Time-of-Flight Mass Spectrometry, ANALYTICAL CHEMISTRY, Vol: 84, Pages: 4095-4103, ISSN: 0003-2700
- Author Web Link
- Cite
- Citations: 32
Pickup K, Gavin A, Jones HB, et al., 2012, The hepatic reductase null mouse as a model for exploring hepatic conjugation of xenobiotics: Application to the metabolism of diclofenac, XENOBIOTICA, Vol: 42, Pages: 195-205, ISSN: 0049-8254
- Author Web Link
- Cite
- Citations: 15
Sarda S, Page C, Pickup K, et al., 2012, Diclofenac metabolism in the mouse: Novel <i>in vivo</i> metabolites identified by high performance liquid chromatography coupled to linear ion trap mass spectrometry, XENOBIOTICA, Vol: 42, Pages: 179-194, ISSN: 0049-8254
- Author Web Link
- Cite
- Citations: 45
Theodoridis GA, Gika HG, Want EJ, et al., 2012, Liquid chromatography-mass spectrometry based global metabolite profiling: A review, ANALYTICA CHIMICA ACTA, Vol: 711, Pages: 7-16, ISSN: 0003-2670
- Author Web Link
- Cite
- Citations: 373
Devenport NA, Reynolds JC, Weston DJ, et al., 2012, Direct extraction of urinary analytes from undeveloped reversed-phase thin layer chromatography plates using a solvent gradient combined with on-line electrospray ionisation ion mobility-mass spectrometry, ANALYST, Vol: 137, Pages: 3510-3513, ISSN: 0003-2654
- Author Web Link
- Cite
- Citations: 7
Gika HG, Theodoridis GA, Wilson ID, 2012, Application of UHPLC-MS to Metabolomic/metabonomic Studies in Man, UHPLC IN LIFE SCIENCES, Editors: Guillarme, Veuthey, Publisher: ROYAL SOC CHEMISTRY, Pages: 387-428, ISBN: 978-1-84973-549-0
Michopoulos F, Theodoridis G, Smith CJ, et al., 2011, Metabolite profiles from dried blood spots for metabonomic studies using UPLC combined with orthogonal acceleration ToF-MS: effects of different papers and sample storage stability, BIOANALYSIS, Vol: 3, Pages: 2757-2767, ISSN: 1757-6180
- Author Web Link
- Cite
- Citations: 40
Michopoulos F, Edge AM, Hui Y-T, et al., 2011, Extraction methods for the removal of phospholipids and other endogenous material from a biological fluid, BIOANALYSIS, Vol: 3, Pages: 2747-2755, ISSN: 1757-6180
- Author Web Link
- Cite
- Citations: 10
Turner MA, Guallar-Hoyas C, Kent AL, et al., 2011, Comparison of metabolomic profiles obtained using chemical ionization and electron ionization MS in exhaled breath, BIOANALYSIS, Vol: 3, Pages: 2731-2738, ISSN: 1757-6180
- Author Web Link
- Cite
- Citations: 16
Geenen S, Guallar-Hoyas C, Michopoulos F, et al., 2011, HPLC-MS/MS methods for the quantitative analysis of 5-oxoproline (pyroglutamate) in rat plasma and hepatic cell line culture medium, JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, Vol: 56, Pages: 655-663, ISSN: 0731-7085
- Author Web Link
- Cite
- Citations: 29
Samuelsson K, Pickup K, Swales J, et al., 2011, Assessment of pharmacokinetics using chimeric mice with humanized livers, 17th North American Regional ISSX Meeting, Publisher: INFORMA HEALTHCARE, Pages: 156-156, ISSN: 0360-2532
Wilson I, 2011, Global metabolic profiling (metabonomics/metabolomics) using dried blood spots: advantages and pitfalls, BIOANALYSIS, Vol: 3, Pages: 2255-2257, ISSN: 1757-6180
- Author Web Link
- Cite
- Citations: 27
Swann JR, Tuohy KM, Lindfors P, et al., 2011, Variation in Antibiotic-Induced Microbial Recolonization Impacts on the Host Metabolic Phenotypes of Rats, JOURNAL OF PROTEOME RESEARCH, Vol: 10, Pages: 3590-3603, ISSN: 1535-3893
- Author Web Link
- Open Access Link
- Cite
- Citations: 102
Blatherwick EQ, Van Berkel GJ, Pickup K, et al., 2011, Utility of spatially-resolved atmospheric pressure surface sampling and ionization techniques as alternatives to mass spectrometric imaging (MSI) in drug metabolism, XENOBIOTICA, Vol: 41, Pages: 720-734, ISSN: 0049-8254
- Author Web Link
- Cite
- Citations: 37
MacDonald C, Smith C, Michopoulos F, et al., 2011, Identification and quantification of glutathione adducts of clozapine using ultra-high-performance liquid chromatography with orthogonal acceleration time-of-flight mass spectrometry and inductively coupled plasma mass spectrometry, RAPID COMMUNICATIONS IN MASS SPECTROMETRY, Vol: 25, Pages: 1787-1793, ISSN: 0951-4198
- Author Web Link
- Cite
- Citations: 12
Thompson RA, Isin EM, Li Y, et al., 2011, Risk assessment and mitigation strategies for reactive metabolites in drug discovery and development, CHEMICO-BIOLOGICAL INTERACTIONS, Vol: 192, Pages: 65-71, ISSN: 0009-2797
- Author Web Link
- Cite
- Citations: 74
Dunn WB, Broadhurst D, Begley P, et al., 2011, Procedures for large-scale metabolic profiling of serum and plasma using gas chromatography and liquid chromatography coupled to mass spectrometry, NATURE PROTOCOLS, Vol: 6, Pages: 1060-1083, ISSN: 1754-2189
- Author Web Link
- Cite
- Citations: 1832
Spagou K, Theodoridis G, Wilson I, et al., 2011, A GC-MS metabolic profiling study of plasma samples from mice on low- and high-fat diets, JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, Vol: 879, Pages: 1467-1475, ISSN: 1570-0232
- Author Web Link
- Cite
- Citations: 26
Geenen S, Michopoulos F, Kenna JG, et al., 2011, HPLC-MS/MS methods for the quantitative analysis of ophthalmic acid in rodent plasma and hepatic cell line culture medium, JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, Vol: 54, Pages: 1128-1135, ISSN: 0731-7085
- Author Web Link
- Cite
- Citations: 16
Koimtzis T, Goddard NJ, Wilson I, et al., 2011, Assessment of the Feasibility of the Use of Conductive Polymers in the Fabrication of Ion Mobility Spectrometers, ANALYTICAL CHEMISTRY, Vol: 83, Pages: 2613-2621, ISSN: 0003-2700
- Author Web Link
- Cite
- Citations: 4
Rainville PD, Smith NW, Wilson ID, et al., 2011, Addressing the challenge of limited sample volumes in <i>in vitro</i> studies with capillary-scale microfluidic LC-MS/MS, BIOANALYSIS, Vol: 3, Pages: 873-882, ISSN: 1757-6180
- Author Web Link
- Cite
- Citations: 13
Park BK, Boobis A, Clarke S, et al., 2011, Managing the challenge of chemically reactive metabolites in drug development, NATURE REVIEWS DRUG DISCOVERY, Vol: 10, Pages: 292-306, ISSN: 1474-1776
- Author Web Link
- Cite
- Citations: 341
Swann JR, Want EJ, Geier FM, et al., 2011, Systemic gut microbial modulation of bile acid metabolism in host tissue compartments, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 108, Pages: 4523-4530, ISSN: 0027-8424
- Author Web Link
- Cite
- Citations: 507
Theodoridis G, Gika HG, Wilson ID, 2011, MASS SPECTROMETRY-BASED HOLISTIC ANALYTICAL APPROACHES FOR METABOLITE PROFILING IN SYSTEMS BIOLOGY STUDIES, MASS SPECTROMETRY REVIEWS, Vol: 30, Pages: 884-906, ISSN: 0277-7037
- Author Web Link
- Cite
- Citations: 153
Loftus N, Barnes A, Ashton S, et al., 2011, Metabonomic Investigation of Liver Profiles of Nonpolar Metabolites Obtained from Alcohol-Dosed Rats and Mice Using High Mass Accuracy MS<SUP>n</SUP> Analysis, JOURNAL OF PROTEOME RESEARCH, Vol: 10, Pages: 705-713, ISSN: 1535-3893
- Author Web Link
- Open Access Link
- Cite
- Citations: 53
Spagou K, Wilson ID, Masson P, et al., 2011, HILIC-UPLC-MS for Exploratory Urinary Metabolic Profiling in Toxicological Studies, ANALYTICAL CHEMISTRY, Vol: 83, Pages: 382-390, ISSN: 0003-2700
- Author Web Link
- Cite
- Citations: 126
Wilson ID, 2011, HPLC-NMR Spectroscopy, eMagRes, Vol: 2011
The linking of NMR spectroscopy on-line with a separation technique, such as high performance liquid chromatography (HPLC or LC), provides many advantages for the structural characterization of unknowns present in mixtures. In particular, the use of this on-line technology can remove the need for the isolation of the analyte in a pure form, thus improving both speed and efficiency. Technical advances such as the implementation of capillary techniques, cryoflow probes, and on-line sample concentration via solid phase extraction have all contributed to increasing the sensitivity of LC-NMR, thereby making the technique increasingly useful in a range of application areas including pharmaceutical and environmental analysis, natural products research, and studies on drug and xenobiotic metabolism. The combination with on-line mass spectrometry (MS) to provide LC-NMR-MS systems enables even more information to be recovered from samples. Here, the methods employed in LC-NMR, and LC-NMR-MS, for the analysis of chromatographic eluents are described and illustrated with representative applications.
Nicholson JK, Wilson ID, Lindon JC, 2011, Pharmacometabonomics as an effector for personalized medicine, PHARMACOGENOMICS, Vol: 12, Pages: 103-111, ISSN: 1462-2416
- Author Web Link
- Cite
- Citations: 100
This data is extracted from the Web of Science and reproduced under a licence from Thomson Reuters. You may not copy or re-distribute this data in whole or in part without the written consent of the Science business of Thomson Reuters.