Imperial College London
Alternate

ProfessorIanWilson

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Visiting Professor
 
 
 
//

Contact

 

i.wilson

 
 
//

Location

 

311Burlington DanesHammersmith Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Letertre:2022:10.1038/s41598-022-21518-4,
author = {Letertre, M and Bhatt, A and Harvey, M and Nicholson, J and Wilson, I and Redinbo, M and Swann, J},
doi = {10.1038/s41598-022-21518-4},
journal = {Scientific Reports},
title = {Characterizing the metabolic effects of the selective inhibition of gut microbial β-glucuronidases in mice},
url = {http://dx.doi.org/10.1038/s41598-022-21518-4},
volume = {12},
year = {2022}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The hydrolysis of xenobiotic glucuronides by gut bacterial glucuronidases reactivates previously detoxified compounds resulting in severe gut toxicity for the host. Selective bacterial β-glucuronidase inhibitors can mitigate this toxicity but their impact on wider host metabolic processes has not been studied. To investigate this the inhibitor 4-(8-(piperazin-1-yl)-1,2,3,4-tetrahydro-[1,2,3]triazino[4′,5′:4,5]thieno[2,3-c]isoquinolin-5-yl)morpholine (UNC10201652, Inh 9) was administered to mice to selectively inhibit a narrow range of bacterial β-glucuronidases in the gut. The metabolomic profiles of the intestinal contents, biofluids, and several tissues involved in the enterohepatic circulation were measured and compared to control animals. No biochemical perturbations were observed in the plasma, liver or gall bladder. In contrast, the metabolite profiles of urine, colon contents, feces and gut wall were altered compared to the controls. Changes were largely restricted to compounds derived from gut microbial metabolism. This work establishes that inhibitors targeted towards bacterial β-glucuronidases modulate the functionality of the intestinal microbiota without adversely impacting the host metabolic system.
AU  - Letertre,M
AU  - Bhatt,A
AU  - Harvey,M
AU  - Nicholson,J
AU  - Wilson,I
AU  - Redinbo,M
AU  - Swann,J
DO  - 10.1038/s41598-022-21518-4
PY  - 2022///
SN  - 2045-2322
TI  - Characterizing the metabolic effects of the selective inhibition of gut microbial β-glucuronidases in mice
T2  - Scientific Reports
UR  - http://dx.doi.org/10.1038/s41598-022-21518-4
UR  - http://hdl.handle.net/10044/1/100292
VL  - 12
ER  -
Download