Imperial College London

ProfessorIanAdcock

Faculty of MedicineNational Heart & Lung Institute

Professor of Respiratory Cell & Molecular Biology
 
 
 
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Contact

 

+44 (0)20 7594 7840ian.adcock Website

 
 
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Location

 

303Guy Scadding BuildingRoyal Brompton Campus

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Summary

 

Summary

Ian Adcock is Professor of Respiratory Cell & Molecular Biology and Head of the Molecular Cell Biology Group at the National Heart & Lung Institute, Imperial College London. He also holds an honorary research position at the Royal Brompton Hospital enabling him to translate the basic research activities into the clinical environment.

Professor Adcock obtained a degree in Biochemistry & Physiology from the University of London and later a PhD in Pharmacology from St Thomas''s Hospital London on the role of nuclear receptors on sexual dimorphic patterns in the rat. He performed postdoctoral training at the MRC Brain Metabolism Unit with Professors Tony Harmar and George Fink and in the Protein Science Laboratory at St Georges’ Hospital with Professor Brian Austen. He joined Professor Peter Barnes at the National Heart & Lung Institute in 1990 to undertake research on the effects of corticosteroids on inflammatory mediators in asthma and COPD. This remains his major research area along with a long-term interest in the mechanisms underlying relative steroid insensitivity in severe asthma and COPD.

Professor Adcock is an internationally recognized scientist in the field of airways disease and inflammation. He has authored and co-authored over 230 scientific articles and has served on the editorial boards of several journals including Respiratory Research, Journal of Inflammation, European Journal of Pharmacology, Drug Discovery Today, Journal of Pharmacology & Experimental Therapeutics and Therapeutic Advances in Respiratory Disease. He has worked as an expert member on national grant-awarding organizations including UK MRC, US NIH, Australian NHMRC and Canadian MRC. He has served on the ERS Council and is currently a member of the ERS Scientific Program Committee and Head of the ERS Airway Pharmacology and Treatment Section.

Professor Adcock is a principal investigator in the Medical Research Council/Asthma UK Centre in Allergic Mechanisms of Asthma and in the Wellcome Trust Respiratory Infections Centre. His research is currently funded by grants from the Medical Research Council, Wellcome Trust, BHF, Royal Society, EU, BBSRC, EPSRC and Industrial collaborators. He is also a principal investigator in the European consortium UBIOPRED on mechanisms of severe asthma that is funded through the Innovative Medicine Initiative of the European Union and EFPIA.

Professor Adcock delivered his Inaugural Lecture, entitled ''Steroid Insensitivity in Asthma and COPD'', on 8 November 2006.  The abstract and other details of the lecture can be found here.

Collaborators in NHLI

Related links within the College

Researchers:

Xian Yang (PhD Student)

Collaborators:

Professor Yi-Ke Guo (Computing Science)

Dr Edward Tate (Chemistry) 

External Collaborators

  • Professor Gaetano Caramori (Ferrara)
  • Dr Antonino Di Stefano (Verona)
  • Dr Silvana Morello (Salerno)
  • Dr Adam Barczyk (Katowice)
  • Dr Osborne Almeida (Munich)
  • Dr Matthew Whiteman (Exeter)
  • Professor Paul Winyard (Exeter)
  • Professor Marc Humbert (Paris)
  • Professor Guy Joos (Ghent)
  • Dr Guy Brusselle (Ghent)
  • Dr Irene Heijink (Groningen)
  • Dr Paul Lavender (King's College London)
  • Professor Mark Lindsay (Bath)
  • Professor Bruno Balbi (Verona)
  • Professor Ratko Djukanovic (Southampton)
  • Professor Peter Sterk (Amsterdam)
  • Professor Alan Knox (Nottingham)
  • Professor Charles Auffray (Lyon)
  • Professor Phil Hansbro (Newcastle, NSW)
  • Dr Brian Oliver (Sydney)
  • Dr Xin Yao (Nanjing) 

Publications

Journals

Xu M, Li F, Wang M, et al., 2019, Protective effects of VGX-1027 in PM2.5-induced airway inflammation and bronchial hyperresponsiveness, European Journal of Pharmacology, Vol:842, ISSN:0014-2999, Pages:373-383

Hersh CP, Adcock IM, Celedon JC, et al., 2019, High-Throughput Sequencing in Respiratory, Critical Care, and Sleep Medicine Research An Official American Thoracic Society Workshop Report, Annals of the American Thoracic Society, Vol:16, ISSN:1546-3222, Pages:1-16

Shrine N, Portelli MA, John C, et al., 2019, Moderate-to-severe asthma in individuals of European ancestry: a genome-wide association study, Lancet Respiratory Medicine, Vol:7, ISSN:2213-2600, Pages:20-34

Pavlidis S, Takahashi K, Kwong FNK, et al., 2019, "T2-high" in severe asthma related to blood eosinophil, exhaled nitric oxide and serum periostin, European Respiratory Journal, Vol:53, ISSN:0903-1936

Kwong FNK, Nicholson AG, Pavlidis S, et al., 2018, PGAM5 expression and macrophage signatures in non-small cell lung cancer associated with chronic obstructive pulmonary disease (COPD), Bmc Cancer, Vol:18, ISSN:1471-2407

More Publications