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BibTex format

@article{Yang:2021:10.1111/crj.13407,
author = {Yang, Y and Man, J and Yingwei, O and Adcock, IM and Xin, Y},
doi = {10.1111/crj.13407},
journal = {The Clinical Respiratory Journal},
pages = {1027--1045},
title = {Mechanisms and biomarkers of airway epithelial cell damage in asthma: a review},
url = {http://dx.doi.org/10.1111/crj.13407},
volume = {15},
year = {2021}
}

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TY  - JOUR
AB  - Bronchial asthma is a heterogeneous disease with complex pathological mechanisms representing different phenotypes, including severe asthma. The airway epithelium is a major site of complex pathological changes in severe asthma due, in part, to activation of inflammatory and immune mechanisms in response to noxious agents. Current imaging procedures are unable to accurately measure epithelial and airway remodeling. Damage of airway epithelial cells occurs is linked to specific phenotypes and endotypes which provides an opportunity for the identification of biomarkers reflecting epithelial, and airway, remodeling. Identification of patients with more severe epithelial disruption using biomarkers may also provide personalized therapeutic opportunities and/or markers of successful therapeutic intervention. Here, we review the evidence for ongoing epithelial cell dysregulation in the pathogenesis of asthma, the sentinel role of the airway epithelium and how understanding these molecular mechanisms provides the basis for the identification of candidate biomarkers for asthma prediction, prevention, diagnosis, treatment and monitoring.
AU  - Yang,Y
AU  - Man,J
AU  - Yingwei,O
AU  - Adcock,IM
AU  - Xin,Y
DO  - 10.1111/crj.13407
EP  - 1045
PY  - 2021///
SN  - 1752-6981
SP  - 1027
TI  - Mechanisms and biomarkers of airway epithelial cell damage in asthma: a review
T2  - The Clinical Respiratory Journal
UR  - http://dx.doi.org/10.1111/crj.13407
UR  - https://www.ncbi.nlm.nih.gov/pubmed/34097803
UR  - https://onlinelibrary.wiley.com/doi/10.1111/crj.13407
UR  - http://hdl.handle.net/10044/1/89598
VL  - 15
ER  -

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