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@article{Luecken:2022:10.1183/13993003.02057-2021,
author = {Luecken, MD and Zaragosi, L-E and Madissoon, E and Sikkema, L and Firsova, AB and De, Domenico E and Kuemmerle, L and Saglam, A and Berg, M and Gay, ACA and Schniering, J and Mayr, CH and Abalo, XM and Larsson, L and Sountoulidis, A and Teichmann, SA and Van, Eunen K and Koppelman, GH and Saeb-Parsy, K and Leroy, S and Powell, P and Sarkans, U and Timens, W and Lundeberg, J and van, den Berge M and Nilsson, M and Horvath, P and Denning, J and Papatheodorou, I and Schultze, JL and Schiller, HB and Barbry, P and Petoukhov, I and Misharin, AV and Adcock, IM and von, Papen M and Theis, FJ and Samakovlis, C and Meyer, KB and Nawijn, MC},
doi = {10.1183/13993003.02057-2021},
journal = {European Respiratory Journal},
pages = {1--11},
title = {The discovAIR project: a roadmap towards the Human Lung Cell Atlas},
url = {http://dx.doi.org/10.1183/13993003.02057-2021},
volume = {60},
year = {2022}
}

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TY  - JOUR
AB  - The Human Cell Atlas (HCA) consortium aims to establish an atlas of all organs in the healthy human body at single-cell resolution to increase our understanding of basic biological processes that govern development, physiology and anatomy, and to accelerate diagnosis and treatment of disease. The Lung Biological Network of the HCA aims to generate the Human Lung Cell Atlas as a reference for the cellular repertoire, molecular cell states and phenotypes, and cell–cell interactions that characterise normal lung homeostasis in healthy lung tissue. Such a reference atlas of the healthy human lung will facilitate mapping the changes in the cellular landscape in disease. The discovAIR project is one of six pilot actions for the HCA funded by the European Commission in the context of the H2020 framework programme. discovAIR aims to establish the first draft of an integrated Human Lung Cell Atlas, combining single-cell transcriptional and epigenetic profiling with spatially resolving techniques on matched tissue samples, as well as including a number of chronic and infectious diseases of the lung. The integrated Human Lung Cell Atlas will be available as a resource for the wider respiratory community, including basic and translational scientists, clinical medicine, and the private sector, as well as for patients with lung disease and the interested lay public. We anticipate that the Human Lung Cell Atlas will be the founding stone for a more detailed understanding of the pathogenesis of lung diseases, guiding the design of novel diagnostics and preventive or curative interventions.
AU  - Luecken,MD
AU  - Zaragosi,L-E
AU  - Madissoon,E
AU  - Sikkema,L
AU  - Firsova,AB
AU  - De,Domenico E
AU  - Kuemmerle,L
AU  - Saglam,A
AU  - Berg,M
AU  - Gay,ACA
AU  - Schniering,J
AU  - Mayr,CH
AU  - Abalo,XM
AU  - Larsson,L
AU  - Sountoulidis,A
AU  - Teichmann,SA
AU  - Van,Eunen K
AU  - Koppelman,GH
AU  - Saeb-Parsy,K
AU  - Leroy,S
AU  - Powell,P
AU  - Sarkans,U
AU  - Timens,W
AU  - Lundeberg,J
AU  - van,den Berge M
AU  - Nilsson,M
AU  - Horvath,P
AU  - Denning,J
AU  - Papatheodorou,I
AU  - Schultze,JL
AU  - Schiller,HB
AU  - Barbry,P
AU  - Petoukhov,I
AU  - Misharin,AV
AU  - Adcock,IM
AU  - von,Papen M
AU  - Theis,FJ
AU  - Samakovlis,C
AU  - Meyer,KB
AU  - Nawijn,MC
DO  - 10.1183/13993003.02057-2021
EP  - 11
PY  - 2022///
SN  - 0903-1936
SP  - 1
TI  - The discovAIR project: a roadmap towards the Human Lung Cell Atlas
T2  - European Respiratory Journal
UR  - http://dx.doi.org/10.1183/13993003.02057-2021
UR  - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000886648200004&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=a2bf6146997ec60c407a63945d4e92bb
UR  - https://erj.ersjournals.com/content/60/2/2102057
UR  - http://hdl.handle.net/10044/1/101709
VL  - 60
ER  -

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