Imperial College London
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ProfessorIanAdcock

Faculty of Medicine, National Heart & Lung Institute

Professor of Respiratory Cell & Molecular Biology
 
 
 
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Contact

 

+44 (0)20 7594 7840ian.adcock Website

 
 
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Location

 

304Guy Scadding BuildingRoyal Brompton Campus

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Summary

 

Publications

Citation

BibTex format

@article{Mortaz:2022:10.18502/ijaai.v21i4.10294,
author = {Mortaz, E and Movassaghi, M and Bassir, A and Dezfuli, NK and Roofchayee, ND and Jamaati, H and Garssen, J and Adcock, IM},
doi = {10.18502/ijaai.v21i4.10294},
journal = {Iranian Journal Of Allergy, Asthma and Immunology},
pages = {467--477},
title = {Evaluation of myeloid-derived suppressor cells in the blood of Iranian COVID-19 patients},
url = {http://dx.doi.org/10.18502/ijaai.v21i4.10294},
volume = {21},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The cytokine storm and lymphopenia are reported in coronavirus disease 2019 (COVID-19). Myeloid-derived suppressive cells (MDSCs) exist in two different forms, granulocyte (G-MDSCs) and monocytic (M-MDSCs), that both suppress T-cell function. In COVID-19, the role of chemokines such as interleukin (IL)-8 in recruiting MDSCs is unclear. A recent report has correlated IL-8 and MDSCs with poor clinical outcomes in melanoma patients. In the current study, we evaluated the frequency of MDSCs and their correlation with serum IL-8 levels in severe COVID-19 patients from Iran. Thirty-seven severe patients (8 on ventilation, 29 without ventilation), thirteen moderate COVID-19 patients, and eight healthy subjects participated in this study between 10th April 2020 and 9th March 2021. Clinical and biochemical features, serum, and whole blood were obtained. CD14, CD15, CD11b, and HLA-DR expression on MDSCs was measured by flow cytometry. COVID-19 patients compared to healthy subjects had a greater frequency of M-MDSCs (12.7±13.3% vs 0.19±0.20%,), G-MDSCs (15.8±12.6% vs 0.35±0.40%,) and total-MDSCs (27.5±17.3% vs 0.55±0.41%,). M-MDSC (16.8±15.8% vs 5.4±4.8%,) and total-MDSC (33.3±18.5% vs 17.3±13.3%) frequency was higher in non- ventilated compared to moderate COVID-19 subjects. Serum IL-8 levels were higher in patients with COVID-19 than in normal healthy subjects (6.4±7.8 vs. 0.10±00 pg/mL). Ventilated patients (15.7±6.7 pg/mL), non-ventilated patients (5.7±2.7 pg/mL) and moderate patients (2.8±3.0 pg/mL) had significantly different levels of IL-8.  A negative correlation was found between the frequency of G-MDSCs and the international normalized ratio (INR) test (r=-0.39), and between the frequency of total-MDSCs and oxygen saturation (%) (r=-0.39). COVID-19 patients with severe non-ventilated disease had the highest levels of M-MDSCs. In addition to systemic MDSC
AU  - Mortaz,E
AU  - Movassaghi,M
AU  - Bassir,A
AU  - Dezfuli,NK
AU  - Roofchayee,ND
AU  - Jamaati,H
AU  - Garssen,J
AU  - Adcock,IM
DO  - 10.18502/ijaai.v21i4.10294
EP  - 477
PY  - 2022///
SN  - 1735-1502
SP  - 467
TI  - Evaluation of myeloid-derived suppressor cells in the blood of Iranian COVID-19 patients
T2  - Iranian Journal Of Allergy, Asthma and Immunology
UR  - http://dx.doi.org/10.18502/ijaai.v21i4.10294
UR  - https://www.ncbi.nlm.nih.gov/pubmed/36243935
UR  - http://hdl.handle.net/10044/1/100126
VL  - 21
ER  -
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