Imperial College London
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ProfessorIanAdcock

Faculty of Medicine, National Heart & Lung Institute

Professor of Respiratory Cell & Molecular Biology
 
 
 
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Contact

 

+44 (0)20 7594 7840ian.adcock Website

 
 
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Location

 

304Guy Scadding BuildingRoyal Brompton Campus

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Summary

 

Publications

Citation

BibTex format

@article{Do:2022:10.1038/s41598-022-24766-6,
author = {Do, AR and An, J and Jo, J and Kim, WJ and Kang, HY and Lee, S and Yoon, D and Cho, YS and Adcock, IM and Chung, KF and Won, S and Kim, T-B},
doi = {10.1038/s41598-022-24766-6},
journal = {Scientific Reports},
title = {A genome-wide association study implicates the pleiotropic effect of NMUR2 on asthma and COPD},
url = {http://dx.doi.org/10.1038/s41598-022-24766-6},
volume = {12},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Asthma and chronic obstructive pulmonary disease (COPD) are two distinct diseases that are associated with chronic inflammation. They share common features in terms of their advanced stages and genetic factors. This study aimed to identify novel genes underlying both asthma and COPD using genome-wide association study (GWAS) to differentiate between the two diseases. We performed a GWAS of asthma and COPD in 7828 Koreans from three hospitals. In addition, we investigated genetic correlations. The UK Biobank dataset was used for the replication studies. We found that rs2961757, located near neuromedin U receptor 2 (NMUR2) on chromosome 5, was genome-wide significant ([Formula: see text] = 0.44, P-valueAsthma-COPD = 3.41 × 10-8), and significant results were replicated with the UK Biobank data ([Formula: see text] = 0.04, P-valueAsthma-COPD = 0.0431). A positive genetic correlation was observed between asthma and COPD (39.8% in the Korean dataset and 49.8% in the UK Biobank dataset). In this study, 40-45% of the genetic effects were common to asthma and COPD. Moreover, NMUR2 increases the risk of asthma development and suppresses COPD development. This indicates that NMUR2 allows for better differentiation of both diseases, which can facilitate tailored medical therapy.
AU  - Do,AR
AU  - An,J
AU  - Jo,J
AU  - Kim,WJ
AU  - Kang,HY
AU  - Lee,S
AU  - Yoon,D
AU  - Cho,YS
AU  - Adcock,IM
AU  - Chung,KF
AU  - Won,S
AU  - Kim,T-B
DO  - 10.1038/s41598-022-24766-6
PY  - 2022///
SN  - 2045-2322
TI  - A genome-wide association study implicates the pleiotropic effect of NMUR2 on asthma and COPD
T2  - Scientific Reports
UR  - http://dx.doi.org/10.1038/s41598-022-24766-6
UR  - https://www.ncbi.nlm.nih.gov/pubmed/36543808
UR  - http://hdl.handle.net/10044/1/101959
VL  - 12
ER  -
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