Publications
923 results found
Elenkov A, Wirestrand E, Hagsund A, et al., 2023, Non-reproductive effects of follicle-stimulating hormone in young men, ANDROLOGY, Vol: 11, Pages: 471-477, ISSN: 2047-2919
Ivell R, Heng K, Severn K, et al., 2022, The Leydig cell biomarker INSL3 as a predictor of age-related morbidity: Findings from the EMAS cohort, FRONTIERS IN ENDOCRINOLOGY, Vol: 13, ISSN: 1664-2392
Wu FCW, Huhtaniemi IT, 2022, Preface, REVIEWS IN ENDOCRINE & METABOLIC DISORDERS, Vol: 23, Pages: 1105-1107, ISSN: 1389-9155
Huhtaniemi I, Jayasena C, 2022, Androgens part 2: Emerging areas, BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM, Vol: 36, ISSN: 1521-690X
Simoni M, Huhtaniemi I, Casarini L, et al., 2022, Editorial: Follicle-stimulating hormone: Fertility and beyond-volume II, FRONTIERS IN ENDOCRINOLOGY, Vol: 13, ISSN: 1664-2392
Huhtaniemi I, Jayasena C, 2022, Androgens part 1: State-of-the-art, Best Practice & Research Clinical Endocrinology & Metabolism, Pages: 1-2, ISSN: 1521-690X
Anand-Ivell R, Heng K, Severn K, et al., 2022, Association of age, hormonal, and lifestyle factors with the Leydig cell biomarker INSL3 in aging men from the European Male Aging Study cohort, ANDROLOGY, Vol: 10, Pages: 1328-1338, ISSN: 2047-2919
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- Citations: 4
Huhtaniemi I, 2022, The first report on homozygous INHA inactivation in humans, EUROPEAN JOURNAL OF ENDOCRINOLOGY, Vol: 187, Pages: C1-C2, ISSN: 0804-4643
Huhtaniemi IT, Wu FCW, 2022, Ageing male (part I): Pathophysiology and diagnosis of functional hypogonadism, BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM, Vol: 36, ISSN: 1521-690X
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- Citations: 4
Deiktakis EE, Ieronymaki E, Zaren P, et al., 2022, Impact of add-back FSH on human and mouse prostate following gonadotropin ablation by GnRH antagonist treatment, ENDOCRINE CONNECTIONS, Vol: 11
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- Citations: 1
Lundin K, Sepponen K, Vayrynen P, et al., 2022, Human pluripotent stem cell-derived cells endogenously expressing follicle-stimulating hormone receptors: modeling the function of an inactivating receptor mutation, MOLECULAR HUMAN REPRODUCTION, Vol: 28, ISSN: 1360-9947
Overman MJ, Pendleton N, O'Neill TW, et al., 2022, <p>Reproductive hormone levels, androgen receptor CAG repeat length and their longitudinal relationships with decline in cognitive subdomains in men: The European Male Ageing Study</p>, PHYSIOLOGY & BEHAVIOR, Vol: 252, ISSN: 0031-9384
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- Citations: 1
Patyra K, Lof C, Jaeschke H, et al., 2022, Congenital Hypothyroidism and Hyperthyroidism Alters Adrenal Gene Expression, Development, and Function, THYROID, Vol: 32, Pages: 459-471, ISSN: 1050-7256
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- Citations: 2
Antonio L, Wu FCW, Moors H, et al., 2022, Erectile dysfunction predicts mortality in middle-aged and older men independent of their sex steroid status, AGE AND AGEING, Vol: 51, ISSN: 0002-0729
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- Citations: 1
Rivero-Muller A, Huhtaniemi I, 2022, Genetic variants of gonadotrophins and their receptors: Impact on the diagnosis and management of the infertile patient, BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM, Vol: 36, ISSN: 1521-690X
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- Citations: 2
Oduwole OO, Huhtaniemi IT, Misrahi M, 2021, The Roles of Luteinizing Hormone, Follicle-Stimulating Hormone and Testosterone in Spermatogenesis and Folliculogenesis Revisited, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, Vol: 22
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- Citations: 12
Dejaeger M, Antonio L, Bouillon R, et al., 2021, Aging Men With Insufficient Vitamin D Have a Higher Mortality Risk: No Added Value of its Free Fractions or Active Form, JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, Vol: 107, Pages: E1212-E1220, ISSN: 0021-972X
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- Citations: 3
Pulawska K, Ponikwicka-Tyszko D, Lebiedzinska W, et al., 2021, Novel expression of zona pellucida 3 protein in normal testis; potential functional implications, MOLECULAR AND CELLULAR ENDOCRINOLOGY, Vol: 539, ISSN: 0303-7207
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- Citations: 1
Dupont J, Antonio L, Dedeyne L, et al., 2021, Inflammatory markers are associated with quality of life, physical activity, and gait speed but not sarcopenia in aged men (40-79 years), JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE, Vol: 12, Pages: 1818-1831, ISSN: 2190-5991
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- Citations: 9
Priskorn L, Tottenborg SS, Almstrup K, et al., 2021, RUBIC (ReproUnion Biobank and Infertility Cohort): A binational clinical foundation to study risk factors, life course, and treatment of infertility and infertility-related morbidity, ANDROLOGY, Vol: 9, Pages: 1828-1842, ISSN: 2047-2919
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- Citations: 8
Chalmel F, Giwercman A, Huhtaniemi I, et al., 2021, In memoriam: Bernard Jegou, humanist scientist, ANDROLOGY, Vol: 9, Pages: 1023-1024, ISSN: 2047-2919
Corona G, Rastrelli G, Bartfai G, et al., 2021, Self-Reported Shorter Than Desired Ejaculation Latency and Related Distress-Prevalence and Clinical Correlates: Results From the European Male Ageing Study, JOURNAL OF SEXUAL MEDICINE, Vol: 18, Pages: 908-919, ISSN: 1743-6095
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- Citations: 3
Jonas K, Rivero-Müller A, Oduwole O, et al., 2021, The luteinizing hormone receptor knock-out mouse as a tool to probe the in vivo 1 actions of gonadotropic hormones/receptors in females, Endocrinology, Vol: 162, Pages: 1-13, ISSN: 0013-7227
Mouse models with altered gonadotropin functions have provided invaluable insight into the functions of these hormones/receptors. Here we describe the repurposing of the infertile and hypogonadal luteinizing hormone receptor (LHR) knockout mouse model (LuRKO), to address outstanding questions in reproductive physiology. Using crossbreeding strategies and physiological and histological analyses, we first addressed the physiological relevance of forced LHR homomerization in female mice using BAC expression of 2 ligand-binding and signaling deficient mutant LHR, respectively, that have previously shown to undergo functional complementation and rescue the hypogonadal phenotype of male LuRKO mice. In female LuRKO mice, coexpression of signaling and binding deficient LHR mutants failed to rescue the hypogonadal and anovulatory phenotype. This was apparently due to the low-level expression of the 2 mutant LHR and potential lack of luteinizing hormone (LH)/LHR-dependent pleiotropic signaling that has previously been shown at high receptor densities to be essential for ovulation. Next, we utilized a mouse model overexpressing human chorionic gonadotropin (hCG) with increased circulating “LH/hCG”-like bioactivity to ~40 fold higher than WT females, to determine if high circulating hCG in the LuRKO background could reveal putative LHR-independent actions. No effects were found, thus, suggesting that LH/hCG mediate their gonadal and non-gonadal effects solely via LHR. Finally, targeted expression of a constitutively active follicle stimulating hormone receptor (FSHR) progressed antral follicles to preovulatory follicles and displayed phenotypic markers of enhanced estrogenic activity but failed to induce ovulation in LuRKO mice. This study highlights the critical importance and precise control of functional LHR and FSHR for mediating ovarian functions and of the potential repurposing of existing genetically modified mouse models in answering outstanding questions in
Oduwole OO, Poliandri A, Okolo A, et al., 2021, Follicle-stimulating hormone promotes growth of human prostate cancer cell line-derived tumor xenografts, FASEB JOURNAL, Vol: 35, ISSN: 0892-6638
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- Citations: 6
NCD Risk Factor Collaboration NCD-RisC, Iurilli N, 2021, Heterogeneous contributions of change in population distribution of body-mass index to change in obesity and underweight, eLife, Vol: 10, ISSN: 2050-084X
From 1985 to 2016, the prevalence of underweight decreased, and that of obesity and severe obesity increased, in most regions, with significant variation in the magnitude of these changes across regions. We investigated how much change in mean body mass index (BMI) explains changes in the prevalence of underweight, obesity, and severe obesity in different regions using data from 2896 population-based studies with 187 million participants. Changes in the prevalence of underweight and total obesity, and to a lesser extent severe obesity, are largely driven by shifts in the distribution of BMI, with smaller contributions from changes in the shape of the distribution. In East and Southeast Asia and sub-Saharan Africa, the underweight tail of the BMI distribution was left behind as the distribution shifted. There is a need for policies that address all forms of malnutrition by making healthy foods accessible and affordable, while restricting unhealthy foods through fiscal and regulatory restrictions.
Zhou B, Carrillo-Larco RM, Danaei G, et al., 2021, Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019: a pooled analysis of 1201 population-representative studies with 104 million participants, The Lancet, Vol: 398, Pages: 957-980, ISSN: 0140-6736
Rodriguez-Martinez A, Zhou B, Sophiea MK, et al., 2020, Height and body-mass index trajectories of school-aged children and adolescents from 1985 to 2019 in 200 countries and territories: a pooled analysis of 2181 population-based studies with 65 million participants, The Lancet, Vol: 396, Pages: 1511-1524, ISSN: 0140-6736
SummaryBackgroundComparable global data on health and nutrition of school-aged children and adolescents are scarce. We aimed to estimate age trajectories and time trends in mean height and mean body-mass index (BMI), which measures weight gain beyond what is expected from height gain, for school-aged children and adolescents.MethodsFor this pooled analysis, we used a database of cardiometabolic risk factors collated by the Non-Communicable Disease Risk Factor Collaboration. We applied a Bayesian hierarchical model to estimate trends from 1985 to 2019 in mean height and mean BMI in 1-year age groups for ages 5–19 years. The model allowed for non-linear changes over time in mean height and mean BMI and for non-linear changes with age of children and adolescents, including periods of rapid growth during adolescence.FindingsWe pooled data from 2181 population-based studies, with measurements of height and weight in 65 million participants in 200 countries and territories. In 2019, we estimated a difference of 20 cm or higher in mean height of 19-year-old adolescents between countries with the tallest populations (the Netherlands, Montenegro, Estonia, and Bosnia and Herzegovina for boys; and the Netherlands, Montenegro, Denmark, and Iceland for girls) and those with the shortest populations (Timor-Leste, Laos, Solomon Islands, and Papua New Guinea for boys; and Guatemala, Bangladesh, Nepal, and Timor-Leste for girls). In the same year, the difference between the highest mean BMI (in Pacific island countries, Kuwait, Bahrain, The Bahamas, Chile, the USA, and New Zealand for both boys and girls and in South Africa for girls) and lowest mean BMI (in India, Bangladesh, Timor-Leste, Ethiopia, and Chad for boys and girls; and in Japan and Romania for girls) was approximately 9–10 kg/m2. In some countries, children aged 5 years started with healthier height or BMI than the global median and, in some cases, as healthy as the best performing countries, but they became
Ponikwicka-Tyszko D, Chrusciel M, Pulawska K, et al., 2020, Mifepristone Treatment Promotes Testicular Leydig Cell Tumor Progression in Transgenic Mice, CANCERS, Vol: 12
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- Citations: 6
Kumar TR, Huhtaniemi I, 2020, An interview with Professor Ilpo Huhtaniemi, BIOLOGY OF REPRODUCTION, Vol: 103, Pages: 909-911, ISSN: 0006-3363
Huhtaniemi IT, 2020, Electroacupuncture Mimics Exercise in Affecting Gene Expression of Skeletal Muscle, JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, Vol: 105, Pages: E2645-E2646, ISSN: 0021-972X
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