Imperial College London

ProfessorIlpoHuhtaniemi

Faculty of MedicineDepartment of Metabolism, Digestion and Reproduction

Emeritus Professor of Reproductive Endocrinology
 
 
 
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Contact

 

ilpo.huhtaniemi Website

 
 
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Location

 

Institute of Reproductive and Developmental BiologyHammersmith Campus

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Summary

 

Publications

Publication Type
Year
to

912 results found

Simoni M, Huhtaniemi I, Casarini L, Santi Det al., 2022, Editorial: Follicle-stimulating hormone: Fertility and beyond-volume II, FRONTIERS IN ENDOCRINOLOGY, Vol: 13, ISSN: 1664-2392

Journal article

Overman MJ, Pendleton N, O'Neill TW, Bartfai G, Casanueva FF, Forti G, Rastrelli G, Giwercman A, Han TS, Huhtaniemi IT, Slowikowska-Hilczer J, Lean MEJ, Punab M, Lee DM, Antonio L, Gielen E, Rutter MK, Vanderschueren D, Wu FCW, Tournoy Jet al., 2022, <p>Reproductive hormone levels, androgen receptor CAG repeat length and their longitudinal relationships with decline in cognitive subdomains in men: The European Male Ageing Study</p>, PHYSIOLOGY & BEHAVIOR, Vol: 252, ISSN: 0031-9384

Journal article

Huhtaniemi I, Jayasena C, 2022, Androgens part 1: State-of-the-art, Best Practice &amp; Research Clinical Endocrinology &amp; Metabolism, Pages: 1-2, ISSN: 1521-690X

Journal article

Anand-Ivell R, Heng K, Severn K, Antonio L, Bartfai G, Casanueva FF, Huhtaniemi IT, Giwercman A, Maggi M, O'Neill TW, Punab M, Rastrelli G, Slowikowska-Hilczer J, Tournoy J, Vanderschueren D, Wu FCW, Ivell Ret al., 2022, Association of age, hormonal, and lifestyle factors with the Leydig cell biomarker INSL3 in aging men from the European Male Aging Study cohort, ANDROLOGY, ISSN: 2047-2919

Journal article

Lundin K, Sepponen K, Vayrynen P, Liu X, Yohannes DA, Survila M, Ghimire B, Kansakoski J, Katayama S, Partanen J, Vuoristo S, Paloviita P, Rahman N, Raivio T, Luiro K, Huhtaniemi I, Varjosalo M, Tuuri T, Tapanainen JSet al., 2022, Human pluripotent stem cell-derived cells endogenously expressing follicle-stimulating hormone receptors: modeling the function of an inactivating receptor mutation, MOLECULAR HUMAN REPRODUCTION, Vol: 28, ISSN: 1360-9947

Journal article

Antonio L, Wu FCW, Moors H, Mathei C, Huhtaniemi IT, Rastrelli G, Dejaeger M, O'Neill TW, Pye SR, Forti G, Maggi M, Casanueva FF, Slowikowska-Hilczer J, Punab M, Tournoy J, Vanderschueren D, Petrone L, Corona G, Borghs H, Kula K, Walczak-Jedrzejowska R, Huhtaniemi I, Giwercman A, Wu F, Silman A, O'Neill T, Finn J, Pye S, Casanueva F, Crujeiras AB, Bartfai G, Foldesi I, Fejes I, Korrovitz Pet al., 2022, Erectile dysfunction predicts mortality in middle-aged and older men independent of their sex steroid status, AGE AND AGEING, Vol: 51, ISSN: 0002-0729

Journal article

Patyra K, Lof C, Jaeschke H, Undeutsch H, Zheng HS, Tyystjarvi S, Pulawska K, Doroszko M, Chrusciel M, Loo B-M, Kurkijarvi R, Zhang F-P, Huang C-CJ, Ohlsson C, Kero A, Poutanen M, Toppari J, Paschke R, Rahman N, Huhtaniemi I, Jaaskelainen J, Kero Jet al., 2022, Congenital Hypothyroidism and Hyperthyroidism Alters Adrenal Gene Expression, Development, and Function, THYROID, Vol: 32, Pages: 459-471, ISSN: 1050-7256

Journal article

Rivero-Muller A, Huhtaniemi I, 2022, Genetic variants of gonadotrophins and their receptors: Impact on the diagnosis and management of the infertile patient, BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM, Vol: 36, ISSN: 1521-690X

Journal article

Oduwole OO, Huhtaniemi IT, Misrahi M, 2021, The Roles of Luteinizing Hormone, Follicle-Stimulating Hormone and Testosterone in Spermatogenesis and Folliculogenesis Revisited, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, Vol: 22

Journal article

Dejaeger M, Antonio L, Bouillon R, Moors H, Wu FCW, O'Neill TW, Huhtaniemi IT, Rastrelli G, Forti G, Maggi M, Casanueva FF, Slowikowska-Hilczer J, Punab M, Gielen E, Tournoy J, Vanderschueren Det al., 2021, Aging Men With Insufficient Vitamin D Have a Higher Mortality Risk: No Added Value of its Free Fractions or Active Form, JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, Vol: 107, Pages: E1212-E1220, ISSN: 0021-972X

Journal article

Pulawska K, Ponikwicka-Tyszko D, Lebiedzinska W, Guo P, Bernaczyk P, Pilaszewicz-Puza A, Li X, Chrusciel M, Lupu O, Leskinen S, Makela J-A, Toppari J, Wolczynski S, Bennink HJTC, Huhtaniemi I, Rahman NAet al., 2021, Novel expression of zona pellucida 3 protein in normal testis; potential functional implications, MOLECULAR AND CELLULAR ENDOCRINOLOGY, Vol: 539, ISSN: 0303-7207

Journal article

Dupont J, Antonio L, Dedeyne L, O'Neill TW, Vanderschueren D, Rastrelli G, Maggi M, Bartfai G, Casanueva FF, Giwercman A, Slowikowska-Hilczer J, Punab M, Huhtaniemi IT, Wu FCW, Tournoy J, Koppo K, Gielen Eet al., 2021, Inflammatory markers are associated with quality of life, physical activity, and gait speed but not sarcopenia in aged men (40-79 years), JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE, Vol: 12, Pages: 1818-1831, ISSN: 2190-5991

Journal article

Priskorn L, Tottenborg SS, Almstrup K, Andersson A-M, Axelsson J, Braeuner EV, Elenkov A, Freiesleben NLC, Giwercman YL, Grondahl ML, Hansen AH, Hansen LS, Henic E, Kitlinski ML, Landersoe SK, Lindh C, Lokkegaard EL, Malm J, Olsen KW, Petersen KU, Schmidt L, Stormlund S, Svendsen PF, Vassard D, Wang NF, Zedeler A, Bhasin S, Chavarro J, Eisenberg ML, Hauser R, Huhtaniemi I, Krawetz SA, Marko-Varga G, Salonia A, Toppari J, Juul A, Jorgensen N, Nielsen HS, Pinborg A, Rylander L, Giwercman Aet al., 2021, RUBIC (ReproUnion Biobank and Infertility Cohort): A binational clinical foundation to study risk factors, life course, and treatment of infertility and infertility-related morbidity, ANDROLOGY, Vol: 9, Pages: 1828-1842, ISSN: 2047-2919

Journal article

Chalmel F, Giwercman A, Huhtaniemi I, Jouannet P, Robaire B, Spira Aet al., 2021, In memoriam: Bernard Jegou, humanist scientist, ANDROLOGY, Vol: 9, Pages: 1023-1024, ISSN: 2047-2919

Journal article

Corona G, Rastrelli G, Bartfai G, Casanueva FF, Giwercman A, Antonio L, Slowikowska J, Tournoy J, Punab M, Huhtaniemi IT, Vanderschueren D, O'Neill TW, Wu FCW, Maggi Met al., 2021, Self-Reported Shorter Than Desired Ejaculation Latency and Related Distress-Prevalence and Clinical Correlates: Results From the European Male Ageing Study, JOURNAL OF SEXUAL MEDICINE, Vol: 18, Pages: 908-919, ISSN: 1743-6095

Journal article

Jonas K, Rivero-Müller A, Oduwole O, Peltoketo H, Huhtaniemi Iet al., 2021, The luteinizing hormone receptor knock-out mouse as a tool to probe the in vivo 1 actions of gonadotropic hormones/receptors in females, Endocrinology, Vol: 162, Pages: 1-13, ISSN: 0013-7227

Mouse models with altered gonadotropin functions have provided invaluable insight into the functions of these hormones/receptors. Here we describe the repurposing of the infertile and hypogonadal luteinizing hormone receptor (LHR) knockout mouse model (LuRKO), to address outstanding questions in reproductive physiology. Using crossbreeding strategies and physiological and histological analyses, we first addressed the physiological relevance of forced LHR homomerization in female mice using BAC expression of 2 ligand-binding and signaling deficient mutant LHR, respectively, that have previously shown to undergo functional complementation and rescue the hypogonadal phenotype of male LuRKO mice. In female LuRKO mice, coexpression of signaling and binding deficient LHR mutants failed to rescue the hypogonadal and anovulatory phenotype. This was apparently due to the low-level expression of the 2 mutant LHR and potential lack of luteinizing hormone (LH)/LHR-dependent pleiotropic signaling that has previously been shown at high receptor densities to be essential for ovulation. Next, we utilized a mouse model overexpressing human chorionic gonadotropin (hCG) with increased circulating “LH/hCG”-like bioactivity to ~40 fold higher than WT females, to determine if high circulating hCG in the LuRKO background could reveal putative LHR-independent actions. No effects were found, thus, suggesting that LH/hCG mediate their gonadal and non-gonadal effects solely via LHR. Finally, targeted expression of a constitutively active follicle stimulating hormone receptor (FSHR) progressed antral follicles to preovulatory follicles and displayed phenotypic markers of enhanced estrogenic activity but failed to induce ovulation in LuRKO mice. This study highlights the critical importance and precise control of functional LHR and FSHR for mediating ovarian functions and of the potential repurposing of existing genetically modified mouse models in answering outstanding questions in

Journal article

Oduwole OO, Poliandri A, Okolo A, Rawson P, Doroszko M, Chrusciel M, Rahman NA, Serrano de Almeida G, Bevan CL, Koechling W, Huhtaniemi ITet al., 2021, Follicle-stimulating hormone promotes growth of human prostate cancer cell line-derived tumor xenografts, FASEB JOURNAL, Vol: 35, ISSN: 0892-6638

Journal article

NCD Risk Factor Collaboration NCD-RisC, Iurilli N, 2021, Heterogeneous contributions of change in population distribution of body-mass index to change in obesity and underweight, eLife, Vol: 10, ISSN: 2050-084X

From 1985 to 2016, the prevalence of underweight decreased, and that of obesity and severe obesity increased, in most regions, with significant variation in the magnitude of these changes across regions. We investigated how much change in mean body mass index (BMI) explains changes in the prevalence of underweight, obesity, and severe obesity in different regions using data from 2896 population-based studies with 187 million participants. Changes in the prevalence of underweight and total obesity, and to a lesser extent severe obesity, are largely driven by shifts in the distribution of BMI, with smaller contributions from changes in the shape of the distribution. In East and Southeast Asia and sub-Saharan Africa, the underweight tail of the BMI distribution was left behind as the distribution shifted. There is a need for policies that address all forms of malnutrition by making healthy foods accessible and affordable, while restricting unhealthy foods through fiscal and regulatory restrictions.

Journal article

Zhou B, Carrillo-Larco RM, Danaei G, Riley LM, Paciorek CJ, Stevens GA, Gregg EW, Bennett JE, Solomon B, Singleton RKet al., 2021, Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019: a pooled analysis of 1201 population-representative studies with 104 million participants, The Lancet, Vol: 398, Pages: 957-980, ISSN: 0140-6736

Journal article

Rodriguez-Martinez A, Zhou B, Sophiea MK, Bentham J, Paciorek CJ, Iurilli ML, Carrillo-Larco RM, Bennett JE, Di Cesare M, Taddei C, Bixby H, Stevens GA, Riley LM, Cowan MJ, Savin S, Danaei G, Chirita-Emandi A, Kengne AP, Khang YH, Laxmaiah A, Malekzadeh R, Miranda JJ, Moon JS, Popovic SR, Sørensen TI, Soric M, Starc G, Zainuddin AA, Gregg EW, Bhutta ZA, Black R, Abarca-Gómez L, Abdeen ZA, Abdrakhmanova S, Abdul Ghaffar S, Abdul Rahim HF, Abu-Rmeileh NM, Abubakar Garba J, Acosta-Cazares B, Adams RJ, Aekplakorn W, Afsana K, Afzal S, Agdeppa IA, Aghazadeh-Attari J, Aguilar-Salinas CA, Agyemang C, Ahmad MH, Ahmad NA, Ahmadi A, Ahmadi N, Ahmed SH, Ahrens W, Aitmurzaeva G, Ajlouni K, Al-Hazzaa HM, Al-Othman AR, Al-Raddadi R, Alarouj M, AlBuhairan F, AlDhukair S, Ali MM, Alkandari A, Alkerwi A, Allin K, Alvarez-Pedrerol M, Aly E, Amarapurkar DN, Amiri P, Amougou N, Amouyel P, Andersen LB, Anderssen SA, Ängquist L, Anjana RM, Ansari-Moghaddam A, Aounallah-Skhiri H, Araújo J, Ariansen I, Aris T, Arku RE, Arlappa N, Aryal KK, Aspelund T, Assah FK, Assunção MCF, Aung MS, Auvinen J, Avdicová M, Azevedo A, Azimi-Nezhad M, Azizi F, Azmin M, Babu BV, Bæksgaard Jørgensen M, Baharudin A, Bahijri S, Baker JL, Balakrishna N, Bamoshmoosh Met al., 2020, Height and body-mass index trajectories of school-aged children and adolescents from 1985 to 2019 in 200 countries and territories: a pooled analysis of 2181 population-based studies with 65 million participants, The Lancet, Vol: 396, Pages: 1511-1524, ISSN: 0140-6736

SummaryBackgroundComparable global data on health and nutrition of school-aged children and adolescents are scarce. We aimed to estimate age trajectories and time trends in mean height and mean body-mass index (BMI), which measures weight gain beyond what is expected from height gain, for school-aged children and adolescents.MethodsFor this pooled analysis, we used a database of cardiometabolic risk factors collated by the Non-Communicable Disease Risk Factor Collaboration. We applied a Bayesian hierarchical model to estimate trends from 1985 to 2019 in mean height and mean BMI in 1-year age groups for ages 5–19 years. The model allowed for non-linear changes over time in mean height and mean BMI and for non-linear changes with age of children and adolescents, including periods of rapid growth during adolescence.FindingsWe pooled data from 2181 population-based studies, with measurements of height and weight in 65 million participants in 200 countries and territories. In 2019, we estimated a difference of 20 cm or higher in mean height of 19-year-old adolescents between countries with the tallest populations (the Netherlands, Montenegro, Estonia, and Bosnia and Herzegovina for boys; and the Netherlands, Montenegro, Denmark, and Iceland for girls) and those with the shortest populations (Timor-Leste, Laos, Solomon Islands, and Papua New Guinea for boys; and Guatemala, Bangladesh, Nepal, and Timor-Leste for girls). In the same year, the difference between the highest mean BMI (in Pacific island countries, Kuwait, Bahrain, The Bahamas, Chile, the USA, and New Zealand for both boys and girls and in South Africa for girls) and lowest mean BMI (in India, Bangladesh, Timor-Leste, Ethiopia, and Chad for boys and girls; and in Japan and Romania for girls) was approximately 9–10 kg/m2. In some countries, children aged 5 years started with healthier height or BMI than the global median and, in some cases, as healthy as the best performing countries, but they became

Journal article

Ponikwicka-Tyszko D, Chrusciel M, Pulawska K, Bernaczyk P, Sztachelska M, Guo P, Li X, Toppari J, Huhtaniemi IT, Wolczynski S, Rahman NAet al., 2020, Mifepristone Treatment Promotes Testicular Leydig Cell Tumor Progression in Transgenic Mice, CANCERS, Vol: 12

Journal article

Kumar TR, Huhtaniemi I, 2020, An interview with Professor Ilpo Huhtaniemi, BIOLOGY OF REPRODUCTION, Vol: 103, Pages: 909-911, ISSN: 0006-3363

Journal article

Huhtaniemi IT, 2020, Electroacupuncture Mimics Exercise in Affecting Gene Expression of Skeletal Muscle, JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, Vol: 105, Pages: E2645-E2646, ISSN: 0021-972X

Journal article

NCD Risk Factor Collaboration NCD-RisC, 2020, Repositioning of the global epicentre of non-optimal cholesterol, Nature, Vol: 582, Pages: 73-77, ISSN: 0028-0836

High blood cholesterol is typically considered a feature of wealthy western countries1,2. However, dietary and behavioural determinants of blood cholesterol are changing rapidly throughout the world3 and countries are using lipid-lowering medications at varying rates. These changes can have distinct effects on the levels of high-density lipoprotein (HDL) cholesterol and non-HDL cholesterol, which have different effects on human health4,5. However, the trends of HDL and non-HDL cholesterol levels over time have not been previously reported in a global analysis. Here we pooled 1,127 population-based studies that measured blood lipids in 102.6 million individuals aged 18 years and older to estimate trends from 1980 to 2018 in mean total, non-HDL and HDL cholesterol levels for 200 countries. Globally, there was little change in total or non-HDL cholesterol from 1980 to 2018. This was a net effect of increases in low- and middle-income countries, especially in east and southeast Asia, and decreases in high-income western countries, especially those in northwestern Europe, and in central and eastern Europe. As a result, countries with the highest level of non-HDL cholesterol-which is a marker of cardiovascular risk-changed from those in western Europe such as Belgium, Finland, Greenland, Iceland, Norway, Sweden, Switzerland and Malta in 1980 to those in Asia and the Pacific, such as Tokelau, Malaysia, The Philippines and Thailand. In 2017, high non-HDL cholesterol was responsible for an estimated 3.9 million (95% credible interval 3.7 million-4.2 million) worldwide deaths, half of which occurred in east, southeast and south Asia. The global repositioning of lipid-related risk, with non-optimal cholesterol shifting from a distinct feature of high-income countries in northwestern Europe, north America and Australasia to one that affects countries in east and southeast Asia and Oceania should motivate the use of population-based policies and per

Journal article

Rastrelli G, O'Neill T, Corona G, Bartfai G, Casanueva F, Forti G, Vanderschueren D, Slowikowska-Hilczer J, Giwercman A, Punab M, Huhtaniemi I, Wu F, Maggi Met al., 2020, PREDICTORS OF DECLINE IN SEXUAL DESIRE OR DEVELOPMENT OF HYPOACTIVE SEXUAL DESIRE DISORDER: LONGITUDINAL RESULTS FROM THE EUROPEAN MALE AGEING STUDY, Publisher: ELSEVIER SCI LTD, Pages: S145-S145, ISSN: 1743-6095

Conference paper

Rastrelli G, Corona G, O'Neill T, Bartfai G, Casanueva F, Forti G, Vanderschueren D, Slowikowska-Hilczer J, Giwercman A, Punab M, Huhtaniemi I, Wu F, Maggi Met al., 2020, CLINICAL CORRELATES OF SELF-REPORTED PREMATURE EJACULATION WITH OR WITHOUT COMPLAINTS: CROSS-SECTIONAL RESULTS FROM THE EUROPEAN MALE AGEING STUDY, Publisher: ELSEVIER SCI LTD, Pages: S145-S145, ISSN: 1743-6095

Conference paper

Lukasiewicz M, Czerniecki J, Ponikwicka-Tyszko D, Sztachelska M, Hryniewicka M, Nalewajko-Sieliwoniuk E, Wiczkowski W, Banaszewska B, Milewski R, Toppari J, Huhtaniemi I, Rahman NA, Wolczynski Set al., 2020, Placenta is Capable of Protecting the Male Fetus from Exposure to Environmental Bisphenol A, EXPOSURE AND HEALTH, Vol: 13, Pages: 1-14, ISSN: 2451-9766

Journal article

Corona G, Goulis DG, Huhtaniemi I, Zitzmann M, Toppari J, Forti G, Vanderschueren D, Wu FCet al., 2020, European Academy of Andrology (EAA) guidelines* on investigation, treatment and monitoring of functional hypogonadism in males, ANDROLOGY, Vol: 8, Pages: 970-987, ISSN: 2047-2919

Journal article

Sipila P, Junnila A, Hakkarainen J, Huhtaniemi R, Mairinoja L, Zhang FP, Strauss L, Ohlsson C, Kotaja N, Huhtaniemi I, Poutanen Met al., 2020, The lack of HSD17B3 in male mice results in disturbed Leydig cell maturation and endocrine imbalance akin to humans with HSD17B3 deficiency, FASEB JOURNAL, Vol: 34, Pages: 6111-6128, ISSN: 0892-6638

Journal article

Simoni M, Huhtaniemi I, Santi D, Casarini Let al., 2019, Follicle-Stimulating Hormone: Beyond Fertility, FRONTIERS IN ENDOCRINOLOGY, Vol: 10, ISSN: 1664-2392

Journal article

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