Publications
932 results found
Jonas K, Rivero-Müller A, Oduwole O, et al., 2021, The luteinizing hormone receptor knock-out mouse as a tool to probe the in vivo 1 actions of gonadotropic hormones/receptors in females, Endocrinology, Vol: 162, Pages: 1-13, ISSN: 0013-7227
Mouse models with altered gonadotropin functions have provided invaluable insight into the functions of these hormones/receptors. Here we describe the repurposing of the infertile and hypogonadal luteinizing hormone receptor (LHR) knockout mouse model (LuRKO), to address outstanding questions in reproductive physiology. Using crossbreeding strategies and physiological and histological analyses, we first addressed the physiological relevance of forced LHR homomerization in female mice using BAC expression of 2 ligand-binding and signaling deficient mutant LHR, respectively, that have previously shown to undergo functional complementation and rescue the hypogonadal phenotype of male LuRKO mice. In female LuRKO mice, coexpression of signaling and binding deficient LHR mutants failed to rescue the hypogonadal and anovulatory phenotype. This was apparently due to the low-level expression of the 2 mutant LHR and potential lack of luteinizing hormone (LH)/LHR-dependent pleiotropic signaling that has previously been shown at high receptor densities to be essential for ovulation. Next, we utilized a mouse model overexpressing human chorionic gonadotropin (hCG) with increased circulating “LH/hCG”-like bioactivity to ~40 fold higher than WT females, to determine if high circulating hCG in the LuRKO background could reveal putative LHR-independent actions. No effects were found, thus, suggesting that LH/hCG mediate their gonadal and non-gonadal effects solely via LHR. Finally, targeted expression of a constitutively active follicle stimulating hormone receptor (FSHR) progressed antral follicles to preovulatory follicles and displayed phenotypic markers of enhanced estrogenic activity but failed to induce ovulation in LuRKO mice. This study highlights the critical importance and precise control of functional LHR and FSHR for mediating ovarian functions and of the potential repurposing of existing genetically modified mouse models in answering outstanding questions in
Corona G, Rastrelli G, Bartfai G, et al., 2021, Self-Reported Shorter Than Desired Ejaculation Latency and Related Distress-Prevalence and Clinical Correlates: Results From the European Male Ageing Study, JOURNAL OF SEXUAL MEDICINE, Vol: 18, Pages: 908-919, ISSN: 1743-6095
- Author Web Link
- Cite
- Citations: 4
Oduwole OO, Poliandri A, Okolo A, et al., 2021, Follicle-stimulating hormone promotes growth of human prostate cancer cell line-derived tumor xenografts, FASEB JOURNAL, Vol: 35, ISSN: 0892-6638
- Author Web Link
- Cite
- Citations: 7
NCD Risk Factor Collaboration NCD-RisC, Iurilli N, 2021, Heterogeneous contributions of change in population distribution of body-mass index to change in obesity and underweight, eLife, Vol: 10, ISSN: 2050-084X
From 1985 to 2016, the prevalence of underweight decreased, and that of obesity and severe obesity increased, in most regions, with significant variation in the magnitude of these changes across regions. We investigated how much change in mean body mass index (BMI) explains changes in the prevalence of underweight, obesity, and severe obesity in different regions using data from 2896 population-based studies with 187 million participants. Changes in the prevalence of underweight and total obesity, and to a lesser extent severe obesity, are largely driven by shifts in the distribution of BMI, with smaller contributions from changes in the shape of the distribution. In East and Southeast Asia and sub-Saharan Africa, the underweight tail of the BMI distribution was left behind as the distribution shifted. There is a need for policies that address all forms of malnutrition by making healthy foods accessible and affordable, while restricting unhealthy foods through fiscal and regulatory restrictions.
Lukasiewicz M, Czerniecki J, Ponikwicka-Tyszko D, et al., 2021, Placenta is Capable of Protecting the Male Fetus from Exposure to Environmental Bisphenol A, EXPOSURE AND HEALTH, Vol: 13, Pages: 1-14, ISSN: 2451-9766
- Author Web Link
- Cite
- Citations: 13
Zhou B, Carrillo-Larco RM, Danaei G, et al., 2021, Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019: a pooled analysis of 1201 population-representative studies with 104 million participants, The Lancet, Vol: 398, Pages: 957-980, ISSN: 0140-6736
Rodriguez-Martinez A, Zhou B, Sophiea MK, et al., 2020, Height and body-mass index trajectories of school-aged children and adolescents from 1985 to 2019 in 200 countries and territories: a pooled analysis of 2181 population-based studies with 65 million participants, The Lancet, Vol: 396, Pages: 1511-1524, ISSN: 0140-6736
SummaryBackgroundComparable global data on health and nutrition of school-aged children and adolescents are scarce. We aimed to estimate age trajectories and time trends in mean height and mean body-mass index (BMI), which measures weight gain beyond what is expected from height gain, for school-aged children and adolescents.MethodsFor this pooled analysis, we used a database of cardiometabolic risk factors collated by the Non-Communicable Disease Risk Factor Collaboration. We applied a Bayesian hierarchical model to estimate trends from 1985 to 2019 in mean height and mean BMI in 1-year age groups for ages 5–19 years. The model allowed for non-linear changes over time in mean height and mean BMI and for non-linear changes with age of children and adolescents, including periods of rapid growth during adolescence.FindingsWe pooled data from 2181 population-based studies, with measurements of height and weight in 65 million participants in 200 countries and territories. In 2019, we estimated a difference of 20 cm or higher in mean height of 19-year-old adolescents between countries with the tallest populations (the Netherlands, Montenegro, Estonia, and Bosnia and Herzegovina for boys; and the Netherlands, Montenegro, Denmark, and Iceland for girls) and those with the shortest populations (Timor-Leste, Laos, Solomon Islands, and Papua New Guinea for boys; and Guatemala, Bangladesh, Nepal, and Timor-Leste for girls). In the same year, the difference between the highest mean BMI (in Pacific island countries, Kuwait, Bahrain, The Bahamas, Chile, the USA, and New Zealand for both boys and girls and in South Africa for girls) and lowest mean BMI (in India, Bangladesh, Timor-Leste, Ethiopia, and Chad for boys and girls; and in Japan and Romania for girls) was approximately 9–10 kg/m2. In some countries, children aged 5 years started with healthier height or BMI than the global median and, in some cases, as healthy as the best performing countries, but they became
Ponikwicka-Tyszko D, Chrusciel M, Pulawska K, et al., 2020, Mifepristone Treatment Promotes Testicular Leydig Cell Tumor Progression in Transgenic Mice, CANCERS, Vol: 12
- Author Web Link
- Cite
- Citations: 7
Kumar TR, Huhtaniemi I, 2020, An interview with Professor Ilpo Huhtaniemi, BIOLOGY OF REPRODUCTION, Vol: 103, Pages: 909-911, ISSN: 0006-3363
Corona G, Goulis DG, Huhtaniemi I, et al., 2020, European Academy of Andrology (EAA) guidelines* on investigation, treatment and monitoring of functional hypogonadism in males, ANDROLOGY, Vol: 8, Pages: 970-987, ISSN: 2047-2919
- Author Web Link
- Cite
- Citations: 141
Huhtaniemi IT, 2020, Electroacupuncture Mimics Exercise in Affecting Gene Expression of Skeletal Muscle, JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, Vol: 105, Pages: E2645-E2646, ISSN: 0021-972X
NCD Risk Factor Collaboration NCD-RisC, 2020, Repositioning of the global epicentre of non-optimal cholesterol, Nature, Vol: 582, Pages: 73-77, ISSN: 0028-0836
High blood cholesterol is typically considered a feature of wealthy western countries1,2. However, dietary and behavioural determinants of blood cholesterol are changing rapidly throughout the world3 and countries are using lipid-lowering medications at varying rates. These changes can have distinct effects on the levels of high-density lipoprotein (HDL) cholesterol and non-HDL cholesterol, which have different effects on human health4,5. However, the trends of HDL and non-HDL cholesterol levels over time have not been previously reported in a global analysis. Here we pooled 1,127 population-based studies that measured blood lipids in 102.6 million individuals aged 18 years and older to estimate trends from 1980 to 2018 in mean total, non-HDL and HDL cholesterol levels for 200 countries. Globally, there was little change in total or non-HDL cholesterol from 1980 to 2018. This was a net effect of increases in low- and middle-income countries, especially in east and southeast Asia, and decreases in high-income western countries, especially those in northwestern Europe, and in central and eastern Europe. As a result, countries with the highest level of non-HDL cholesterol-which is a marker of cardiovascular risk-changed from those in western Europe such as Belgium, Finland, Greenland, Iceland, Norway, Sweden, Switzerland and Malta in 1980 to those in Asia and the Pacific, such as Tokelau, Malaysia, The Philippines and Thailand. In 2017, high non-HDL cholesterol was responsible for an estimated 3.9 million (95% credible interval 3.7 million-4.2 million) worldwide deaths, half of which occurred in east, southeast and south Asia. The global repositioning of lipid-related risk, with non-optimal cholesterol shifting from a distinct feature of high-income countries in northwestern Europe, north America and Australasia to one that affects countries in east and southeast Asia and Oceania should motivate the use of population-based policies and per
Rastrelli G, Corona G, O'Neill T, et al., 2020, CLINICAL CORRELATES OF SELF-REPORTED PREMATURE EJACULATION WITH OR WITHOUT COMPLAINTS: CROSS-SECTIONAL RESULTS FROM THE EUROPEAN MALE AGEING STUDY, Publisher: ELSEVIER SCI LTD, Pages: S145-S145, ISSN: 1743-6095
Rastrelli G, O'Neill T, Corona G, et al., 2020, PREDICTORS OF DECLINE IN SEXUAL DESIRE OR DEVELOPMENT OF HYPOACTIVE SEXUAL DESIRE DISORDER: LONGITUDINAL RESULTS FROM THE EUROPEAN MALE AGEING STUDY, Publisher: ELSEVIER SCI LTD, Pages: S145-S145, ISSN: 1743-6095
Sipila P, Junnila A, Hakkarainen J, et al., 2020, The lack of HSD17B3 in male mice results in disturbed Leydig cell maturation and endocrine imbalance akin to humans with HSD17B3 deficiency, FASEB JOURNAL, Vol: 34, Pages: 6111-6128, ISSN: 0892-6638
- Author Web Link
- Cite
- Citations: 6
Huhtaniemi I, 2020, How hCG was used as tool to study LH action, 100 YEARS OF HUMAN CHORIONIC GONADOTROPIN, Editors: Cole, Butler, Publisher: ELSEVIER SCIENCE BV, Pages: 151-152, ISBN: 978-0-12-820050-6
Rulli SB, Poutanen M, Huhtaniemi IT, 2020, Phenotypic characterization of transgenic mouse models overproducing hCG, 100 YEARS OF HUMAN CHORIONIC GONADOTROPIN, Editors: Cole, Butler, Publisher: ELSEVIER SCIENCE BV, Pages: 181-191, ISBN: 978-0-12-820050-6
Simoni M, Huhtaniemi I, Santi D, et al., 2019, Follicle-Stimulating Hormone: Beyond Fertility, FRONTIERS IN ENDOCRINOLOGY, Vol: 10, ISSN: 1664-2392
- Author Web Link
- Cite
- Citations: 2
Ponikwicka-Tyszko D, Chrusciel M, Stelmaszewska J, et al., 2019, Molecular mechanisms underlying mifepristone's agonistic action on ovarian cancer progression, EBIOMEDICINE, Vol: 47, Pages: 170-183, ISSN: 2352-3964
- Author Web Link
- Cite
- Citations: 23
Kaufman J-M, Lapauw B, Mahmoud A, et al., 2019, Aging and the Male Reproductive System, ENDOCRINE REVIEWS, Vol: 40, Pages: 906-972, ISSN: 0163-769X
- Author Web Link
- Cite
- Citations: 66
Potorac I, Trehan A, Szymanska K, et al., 2019, Compound heterozygous mutations in the luteinizing hormone receptor signal peptide causing 46, XY disorder of sex development, EUROPEAN JOURNAL OF ENDOCRINOLOGY, Vol: 181, Pages: K11-K20, ISSN: 0804-4643
- Author Web Link
- Cite
- Citations: 5
Eriksson AL, Perry JRB, Coviello AD, et al., 2019, Genetic Determinants of Circulating Estrogen Levels and Evidence of a Causal Effect of Estradiol on Bone Density in Men (vol 103, pg 991, 2018), JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, Vol: 104, Pages: 2580-2580, ISSN: 0021-972X
- Author Web Link
- Cite
- Citations: 1
Conforti A, Vaiarelli A, Cimadomo D, et al., 2019, Pharmacogenetics of FSH Action in the Female, FRONTIERS IN ENDOCRINOLOGY, Vol: 10, ISSN: 1664-2392
- Author Web Link
- Cite
- Citations: 22
Salonia A, Rastrelli G, Hackett G, et al., 2019, Paediatric and adult-onset male hypogonadism, NATURE REVIEWS DISEASE PRIMERS, Vol: 5, ISSN: 2056-676X
- Author Web Link
- Cite
- Citations: 124
Bixby H, Bentham J, Zhou B, et al., 2019, Rising rural body-mass index is the main driver of the global obesity epidemic, Nature, Vol: 569, Pages: 260-264, ISSN: 0028-0836
Body-mass index (BMI) has increased steadily in most countries in parallel with a rise in the proportion of the population who live in cities1,2. This has led to a widely reported view that urbanization is one of the most important drivers of the global rise in obesity3,4,5,6. Here we use 2,009 population-based studies, with measurements of height and weight in more than 112 million adults, to report national, regional and global trends in mean BMI segregated by place of residence (a rural or urban area) from 1985 to 2017. We show that, contrary to the dominant paradigm, more than 55% of the global rise in mean BMI from 1985 to 2017—and more than 80% in some low- and middle-income regions—was due to increases in BMI in rural areas. This large contribution stems from the fact that, with the exception of women in sub-Saharan Africa, BMI is increasing at the same rate or faster in rural areas than in cities in low- and middle-income regions. These trends have in turn resulted in a closing—and in some countries reversal—of the gap in BMI between urban and rural areas in low- and middle-income countries, especially for women. In high-income and industrialized countries, we noted a persistently higher rural BMI, especially for women. There is an urgent need for an integrated approach to rural nutrition that enhances financial and physical access to healthy foods, to avoid replacing the rural undernutrition disadvantage in poor countries with a more general malnutrition disadvantage that entails excessive consumption of low-quality calories.
Rastrelli G, ONeill T, Bartfai G, et al., 2019, SYMPTOMATIC ANDROGEN DEFICIENCY DEVELOPS ONLY WHEN BOTH TOTAL AND FREE TESTOSTERONE DECLINE IN OBESE MEN WHO MAY HAVE INCIDENT BIOCHEMICAL SECONDARY HYPOGONADISM: PROSPECTIVE RESULTS FROM THE EMAS, Publisher: ELSEVIER SCI LTD, Pages: S26-S26, ISSN: 1743-6095
Dizeyi N, Trzybulska D, Al-Jebari Y, et al., 2019, Cell-based evidence regarding the role of FSH in prostate cancer, UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS, Vol: 37, ISSN: 1078-1439
- Author Web Link
- Cite
- Citations: 7
Chrusciel M, Ponikwicka-Tyszko D, Wolczynski S, et al., 2019, Extragonadal FSHR Expression and Function-Is It Real?, FRONTIERS IN ENDOCRINOLOGY, Vol: 10, ISSN: 1664-2392
- Author Web Link
- Cite
- Citations: 40
Lindgren I, Nenonen H, Henic E, et al., 2019, Gonadotropin receptor variants are linked to cumulative live birth rate after in vitro fertilization, JOURNAL OF ASSISTED REPRODUCTION AND GENETICS, Vol: 36, Pages: 29-38, ISSN: 1058-0468
- Author Web Link
- Cite
- Citations: 11
Doroszko M, Chrusciel M, Stelmaszewska J, et al., 2019, GnRH antagonist treatment of malignant adrenocortical tumors, ENDOCRINE-RELATED CANCER, Vol: 26, Pages: 103-117, ISSN: 1351-0088
- Author Web Link
- Cite
- Citations: 12
This data is extracted from the Web of Science and reproduced under a licence from Thomson Reuters. You may not copy or re-distribute this data in whole or in part without the written consent of the Science business of Thomson Reuters.