Imperial College London
Alternate

Professor Irene Roberts

Faculty of Medicine, Department of Immunology and Inflammation

Visiting Professor
 
 
 
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Contact

 

+44 (0)20 3313 2163irene.roberts

 
 
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Assistant

 

Miss Karen Linfield +44 (0)20 3313 3238

 
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Location

 

4S10BHammersmith HospitalHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Iskander:2019:10.1111/bjh.15915,
author = {Iskander, D and Roberts, I and Rees, C and Szydlo, R and Alikian, M and Neale, M and Harrington, Y and Kelleher, P and Karadimitris, A and de, la Fuente J},
doi = {10.1111/bjh.15915},
journal = {British Journal of Haematology},
pages = {321--326},
title = {Impaired cellular and humoral immunity is a feature of Diamond-Blackfan anaemia; experience of 107 unselected cases in the United Kingdom.},
url = {http://dx.doi.org/10.1111/bjh.15915},
volume = {186},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Diamond-Blackfan anaemia (DBA) is a rare bone marrow failure syndrome characterised by anaemia, congenital anomalies and cancer predisposition. Although infections are the second leading cause of mortality in non-transplanted patients, immune function is largely unexplored. We identified quantitative deficits in serum immunoglobulins and/or circulating T, natural killer and B lymphocytes in 59 of 107 unselected patients (55·1%) attending our centre over a 7-year period. Immune abnormalities were independent of ribosomal protein genotype and arose in both steroid-treated and steroid-untreated patients. In summary, these data highlight the high prevalence and spectrum of infections and immune defects in DBA.
AU  - Iskander,D
AU  - Roberts,I
AU  - Rees,C
AU  - Szydlo,R
AU  - Alikian,M
AU  - Neale,M
AU  - Harrington,Y
AU  - Kelleher,P
AU  - Karadimitris,A
AU  - de,la Fuente J
DO  - 10.1111/bjh.15915
EP  - 326
PY  - 2019///
SN  - 1365-2141
SP  - 321
TI  - Impaired cellular and humoral immunity is a feature of Diamond-Blackfan anaemia; experience of 107 unselected cases in the United Kingdom.
T2  - British Journal of Haematology
UR  - http://dx.doi.org/10.1111/bjh.15915
UR  - https://www.ncbi.nlm.nih.gov/pubmed/30980390
UR  - https://onlinelibrary.wiley.com/doi/full/10.1111/bjh.15915
VL  - 186
ER  -
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