Imperial College London


Faculty of MedicineNational Heart & Lung Institute

Professor of Pharmacology in Critical Care Medicine



+44 (0)20 7351 8137j.a.mitchell




Guy Scadding BuildingRoyal Brompton Campus





Jane Mitchell is Head of the Vascular Biology research group at NHLI. Professor Mitchell is a stream lead for the taught MSc course: Genes, Drugs and Stem Cells.

Professor Mitchell completed a PhD in Pharmacology with Sir Professor John R Vane (FRS, Nobel Laureate) and Dr Gilberto De Nucci 1990 before joining Professor Ferid Murad (NAS USA, Nobel Laureate) as a fellow of Northwestern University (Chicago, USA) for her postdoctoral training in the biochemistry of nitric oxide synthase. She returned to work with John Vane on the pharmacology of cyclo-oxygenase isoforms before joining the group of Professor Timothy Williams at the National Heart and Lung Institute, now part of Imperial College.

Professor Mitchell was awarded a Wellcome Trust Career Development Fellowship in 1997 and the Novartis Prize for Pharmacology in 1999 for her contribution to the field of cyclo-oxygeanse biology. Since this time, Professor Mitchell has led her own group - Cardiothoracic Pharmacology - consisting of academics, clinicians, postdoctoral fellows and undergraduate/postgraduate students.

Professor Mitchell is amongst the top 1% of cited pharmacologists world-wide and as such, is a member of Thomson Scientific Highlycited listings ( with more than 150 publications in peer reviewed journals.

Professor Mitchell was awarded the 2009 Rector’s Award for Excellence in Research Supervision and Elected Research Supervision Fellow.

Professor Mitchell was awarded the AstraZeneca Women in Pharmacology Prize in 2012.  She talks about receiving the award here.



Mitchell JA, Kirkby NS, Ahmetaj-Shala B, et al., 2020, Cyclooxygenases and the cardiovascular system, Pharmacology and Therapeutics, ISSN:0163-7258, Pages:107624-107624

Crescente M, Armstrong P, Kirkby N, et al., 2020, Profiling the eicosanoid networks that underlie the anti- and pro-thrombotic effects of aspirin, The Faseb Journal, ISSN:0892-6638

Ahmetaj-Shala B, Kawai R, Marei I, et al., 2020, A bioassay system of autologous human endothelial, smooth muscle cells and leucocytes for use in drug discovery, phenotyping and tissue engineering, The Faseb Journal, Vol:34, ISSN:0892-6638, Pages:1745-1754

Kirkby N, Raouf J, Ahmetaj-Shala B, et al., 2019, Mechanistic definition of the cardiovascular mPGES-1/COX-2/ADMA axis, Cardiovascular Research, ISSN:0008-6363

Mitchell J, Shala F, Elghazouli Y, et al., 2019, Cell-Specific Gene Deletion Reveals the Antithrombotic Function of COX1 and Explains the Vascular COX1/Prostacyclin Paradox, Circulation Research, Vol:125, ISSN:0009-7330, Pages:847-854

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