Imperial College London


Faculty of MedicineNational Heart & Lung Institute

Professor of Pharmacology in Critical Care Medicine



+44 (0)20 7351 8137j.a.mitchell




Guy Scadding BuildingRoyal Brompton Campus





Jane Mitchell is Head of the Vascular Biology research group at NHLI. Professor Mitchell is a stream lead for the taught MSc course: Genes, Drugs and Stem Cells.

Professor Mitchell completed a PhD in Pharmacology with Sir Professor John R Vane (FRS, Nobel Laureate) and Dr Gilberto De Nucci 1990 before joining Professor Ferid Murad (NAS USA, Nobel Laureate) as a fellow of Northwestern University (Chicago, USA) for her postdoctoral training in the biochemistry of nitric oxide synthase. She returned to work with John Vane on the pharmacology of cyclo-oxygenase isoforms before joining the group of Professor Timothy Williams at the National Heart and Lung Institute, now part of Imperial College.

Professor Mitchell was awarded a Wellcome Trust Career Development Fellowship in 1997 and the Novartis Prize for Pharmacology in 1999 for her contribution to the field of cyclo-oxygeanse biology. Since this time, Professor Mitchell has led her own group - Cardiothoracic Pharmacology - consisting of academics, clinicians, postdoctoral fellows and undergraduate/postgraduate students.

Professor Mitchell is amongst the top 1% of cited pharmacologists world-wide and as such, is a member of Thomson Scientific Highlycited listings ( with more than 150 publications in peer reviewed journals.

Professor Mitchell was awarded the 2009 Rector’s Award for Excellence in Research Supervision and Elected Research Supervision Fellow.

Professor Mitchell was awarded the AstraZeneca Women in Pharmacology Prize in 2012.  She talks about receiving the award here.



Ahmetaj-Shala B, Marei I, Kawai R, et al., 2021, Activation and contraction of human ‘vascular’ smooth muscle cells grown from circulating blood progenitors, Frontiers in Cell and Developmental Biology, ISSN:2296-634X

Mitchell J, Shala F, Lopes Pires M, et al., 2021, Endothelial cyclooxygenase-1 paradoxically drives local vasoconstriction and atherogenesis despite underpinning prostacyclin generation, Science Advances, Vol:7, ISSN:2375-2548

Mohamed NA, Abou-Saleh H, Kameno Y, et al., 2021, Studies on metal-organic framework (MOF) nanomedicine preparations of sildenafil for the future treatment of pulmonary arterial hypertension, Scientific Reports, Vol:11, ISSN:2045-2322, Pages:1-8

Mitchell JA, Kirkby NS, Ahmetaj-Shala B, et al., 2021, Cyclooxygenases and the cardiovascular system, Pharmacology and Therapeutics, Vol:217, ISSN:0163-7258, Pages:1-11

Ahmetaj-Shala B, Ricky V, Santosh A, et al., 2020, Cardiorenal tissues express SARS-CoV-2 entry genes and basigin (BSG/CD147) increases with age in endothelial cells, Jacc: Basic to Translational Science, Vol:5, ISSN:2452-302X, Pages:1111-1123

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