Imperial College London
Portrait Picture

Dr Josefin Ahnström

Faculty of Medicine, Department of Immunology and Inflammation

Senior Lecturer in Haematology
 
 
 
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Contact

 

+44 (0)20 3313 4236j.ahnstrom

 
 
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Location

 

5S5Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Gierula:2020:10.1111/jth.15025,
author = {Gierula, M and Ahnstrom, J},
doi = {10.1111/jth.15025},
journal = {Journal of Thrombosis and Haemostasis},
pages = {2801--2811},
title = {Anticoagulant protein S-New insights on interactions and functions},
url = {http://dx.doi.org/10.1111/jth.15025},
volume = {18},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Protein S is a critical regulator of coagulation that functions as a cofactor for the activated protein C (APC) and tissue factor pathway inhibitor (TFPI) pathways. It also has direct anticoagulant functions, inhibiting the intrinsic tenase and prothrombinase complexes. Through these functions, protein S regulates coagulation during both its initiation and its propagation phases. The importance of protein S in hemostatic regulation is apparent from the strong association between protein S deficiencies and increased risk for venous thrombosis. This is most likely because both APC and TFPIα are inefficient anticoagulants in the absence of any cofactors. The detailed molecular mechanisms involved in protein S cofactor functions remain to be fully clarified. However, recent advances in the field have greatly improved our understanding of these functions. Evidence suggests that protein S anticoagulant properties often depend on the presence of synergistic cofactors and the formation of multicomponent complexes on negatively charged phospholipid surfaces. Their high affinity binding to negatively charged phospholipids helps bring the anticoagulant proteins to the membranes, resulting in efficient and targeted regulation of coagulation. In this review, we provide an update on protein S and how it functions as a critical hemostatic regulator.
AU  - Gierula,M
AU  - Ahnstrom,J
DO  - 10.1111/jth.15025
EP  - 2811
PY  - 2020///
SN  - 1538-7836
SP  - 2801
TI  - Anticoagulant protein S-New insights on interactions and functions
T2  - Journal of Thrombosis and Haemostasis
UR  - http://dx.doi.org/10.1111/jth.15025
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000561770600001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://onlinelibrary.wiley.com/doi/10.1111/jth.15025
UR  - http://hdl.handle.net/10044/1/86039
VL  - 18
ER  -
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