Javier Alegre-Abarrategui started at Imperial College in June 2018. He is the Director of Neuropathology of the MS & PD Tissue Bank at Imperial College as well as a Senior Clinical Lecturer in Neuropathology at the Department of Brain Sciences and a Consultant Neuropathologist at Charing Cross Hospital. He has previously worked at the Department of Neuropathology and the Department of Physiology, Anatomy and Genetics at Oxford and the Department of Neuropathology at the Institute of Neurology, London. He’s research focused on genetically-defined forms of PD, the use of human genomic constructs for animal and in vitro functional modelling and autophagy. More recently he has pioneered the development of novel tools to detect in situ early protein aggregates such as alpha-synuclein oligomers in human brain and has started to apply these tools to the dissection of the initial pathogenic processes in PD and Alzheimer’s disease, in particular to elucidate the gene expression pathway alterations linked to the earliest pathological events. He directs the provision of Neuropathology for the MS & PD Tissue Bank at the College as well as for academic and clinical colleagues and tissue users and he leads a research portfolio centred on the Tissue Bank specimens. He is looking forward to meeting colleagues from different disciplines interested in developing novel and exciting ideas to use human tissue for research.
et al., 2021, Tau-proximity ligation assay reveals extensive previously undetected pathology prior to neurofibrillary tangles in preclinical Alzheimer’s disease, Acta Neuropathologica Communications, ISSN:2051-5960
et al., 2020, A single-cell atlas of the human substantia nigra reveals cell-specific pathways associated with neurological disorders, Nature Communications, Vol:11, ISSN:2041-1723
et al., 2019, Selective vulnerability in α-synucleinopathies, Acta Neuropathologica, Vol:138, ISSN:1432-0533, Pages:681-704
et al., 2020, A human single-cell atlas of the Substantia nigra reveals novel cell-specific pathways associated with the genetic risk of Parkinson's disease and neuropsychiatric disorders., SPRINGERNATURE, Pages:71-71, ISSN:1018-4813
et al., 2020, Understanding the pathophysiological role of early tau aggregates in Alzheimer's disease by their direct visualisation in situ, 121st Meeting of the British-Neuropathological-Society / Developmental Neuropathology Symposium, WILEY, Pages:42-42, ISSN:0305-1846