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@article{Pouncey:2018:10.3332/ecancer.2018.868,
author = {Pouncey, AL and Scott, AJ and Alexander, JL and Marchesi, J and Kinross, J},
doi = {10.3332/ecancer.2018.868},
journal = {Ecancermedicalscience},
title = {Gut microbiota, chemotherapy and the host: the influence of the gut microbiota on cancer treatment},
url = {http://dx.doi.org/10.3332/ecancer.2018.868},
volume = {12},
year = {2018}
}

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TY  - JOUR
AB  - The gut microbiota exists in a dynamic balance between symbiosis and pathogenesis and can influence almost any aspect of host physiology. Growing evidence suggests that the gut microbiota not only plays a key role in carcinogenesis but also influences the efficacy and toxicity of anticancer therapy. The microbiota modulates the host response to chemotherapy via numerous mechanisms, including immunomodulation, xenometabolism and alteration of community structure. Furthermore, exploitation of the microbiota offers opportunities for the personalisation of chemotherapeutic regimens and the development of novel therapies. In this article, we explore the host-chemotherapeutic microbiota axis, from basic science to clinical research, and describe how it may change the face of cancer treatment.
AU  - Pouncey,AL
AU  - Scott,AJ
AU  - Alexander,JL
AU  - Marchesi,J
AU  - Kinross,J
DO  - 10.3332/ecancer.2018.868
PY  - 2018///
SN  - 1754-6605
TI  - Gut microbiota, chemotherapy and the host: the influence of the gut microbiota on cancer treatment
T2  - Ecancermedicalscience
UR  - http://dx.doi.org/10.3332/ecancer.2018.868
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000444744800005&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/66863
VL  - 12
ER  -

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