Imperial College London
Portrait Picture

DrJamesAlexander

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Honorary Senior Lecturer
 
 
 
//

Contact

 

j.alexander

 
 
//

Location

 

Queen Elizabeth the Queen Mother Wing (QEQM)St Mary's Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Qiu:2020:10.3390/biom10081145,
author = {Qiu, S and Nikolaou, S and Zhu, J and Jeffery, P and Goldin, R and Kinross, J and Alexander, J and Rasheed, S and Tekkis, P and Kontovounisios, C},
doi = {10.3390/biom10081145},
journal = {Biomolecules},
pages = {1--15},
title = {Characterisation of the expression of neurotensin and its receptors in human colorectal cancer and its clinical implications},
url = {http://dx.doi.org/10.3390/biom10081145},
volume = {10},
year = {2020}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Introduction: Colorectal Cancer (CRC) accounts for 9% of cancer deaths globally. Hormonal pathways play important roles in some cancers. This study investigated the association of CRC expression of neurotensin (NTS), NTS receptors 1 and 3 (NTSR1 and NTSR3) and clinical outcomes. Methods: A prospective cohort study which quantifies the protein expression of NTS, NTSR1 and NTSR3 in human CRCs using immunohistochemistry. Expression levels were then compared with clinico-pathological outcome including histological grade, overall survival (OS) and disease-free survival (DFS). Results: Sixty-four patients were enrolled with median follow-up of 44.0 months. There was significantly higher expression of NTS in cancer tissue in CRC with higher T stages (p < 0.01), N stages (p = 0.03), and AJCC clinical stages (p = 0.04). There was significantly higher expression of NTS, NTSR1 and NTSR3 in cancer tissue compared to surrounding normal epithelium (median H-score 163.5 vs 97.3, p < 0.01). There was significantly shorter DFS in individuals with CRC with high levels of NTS compared to lower levels of NTS (35.8 months 95% CI 28.7–42.8 months vs 46.4 months 95% CI 42.2–50.5 months, respectively, p = 0.02). Above median NTS expression in cancer tissue was a significant risk factor for disease recurrence (HR 4.10, 95% CI 1.14–14.7, p = 0.03). Discussion: The expression of NTS and its receptors has the potential to be utilised as a predictive and prognostic marker in colorectal cancer for postoperative selection for adjuvant therapy and identify individuals for novel therapies targeting the neurotensinergic pathways. Conclusions: High NTS expression appears to be associated with more advanced CRC and worse DFS.
AU  - Qiu,S
AU  - Nikolaou,S
AU  - Zhu,J
AU  - Jeffery,P
AU  - Goldin,R
AU  - Kinross,J
AU  - Alexander,J
AU  - Rasheed,S
AU  - Tekkis,P
AU  - Kontovounisios,C
DO  - 10.3390/biom10081145
EP  - 15
PY  - 2020///
SN  - 2218-273X
SP  - 1
TI  - Characterisation of the expression of neurotensin and its receptors in human colorectal cancer and its clinical implications
T2  - Biomolecules
UR  - http://dx.doi.org/10.3390/biom10081145
UR  - https://www.mdpi.com/2218-273X/10/8/1145
UR  - http://hdl.handle.net/10044/1/82176
VL  - 10
ER  -
Download