Imperial College London

DrJayantaBanerjee

Faculty of MedicineDepartment of Metabolism, Digestion and Reproduction

Honorary Clinical Senior Lecturer
 
 
 
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Contact

 

+44 (0)20 3313 7308j.banerjee

 
 
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Location

 

524Hammersmith HouseHammersmith Campus

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Summary

 

Publications

Publication Type
Year
to

85 results found

Banerjee J, Khatib N, Mansfield RC, Sathiyamurthy S, Kariholu U, Lees Cet al., 2023, Continuous non-invasive measurement of cardiac output in neonatal intensive care using regional impedance cardiography: a prospective observational study., Arch Dis Child Fetal Neonatal Ed

OBJECTIVES: To compare agreement between echocardiography and regional impedance cardiography (RIC)-derived cardiac output (CO), and to construct indicative normative ranges of CO for gestational age groups. DESIGN, SETTING AND PARTICIPANTS: Prospective cohort observational study performed in a tertiary centre in London, UK, including neonates born between 25 and 42 weeks' gestational age. EXPOSURES: Neonates on the postnatal ward had 2 hours of RIC monitoring; neonates in intensive care had RIC monitoring for the first 72 hours, then weekly for 2 hours, with concomitant echocardiography measures. MAIN OUTCOMES AND MEASURES: RIC was used to measure CO continuously. Statistical analyses were performed using R (V.4.2.2; R Core Team 2022). RIC-derived CO and echocardiography-derived CO were compared using Pearson's correlations and Bland-Altman analyses. Differences in RIC-derived CO between infants born extremely, very and late preterm were assessed using analyses of variance and mixed-effects modelling. RESULTS: 127 neonates (22 extremely, 46 very, 29 late preterm and 30 term) were included. RIC and echocardiography-measured weight-adjusted CO were correlated (r=0.62, p<0.001) with a Bland-Altman bias of -31 mL/min/kg (limits of agreement -322 to 261 mL/min/kg). The RIC-derived CO fell over 12 hours, then increased until 72 hours after birth. The 72-hour weight-adjusted mean CO was higher in extremely preterm (424±158 mL/min/kg) compared with very (325±131 mL/min/kg, p<0.001) and late preterm (237±81 mL/min/kg, p<0.001) neonates; this difference disappeared by 2-3 weeks of age. CONCLUSIONS: RIC is valid for continuous, non-invasive CO measurement in neonates. Indicative normative CO ranges could help clinicians to make more informed haemodynamic management decisions, which should be explored in future studies. TRIAL REGISTRATION NUMBER: NCT04064177.

Journal article

Mansfield R, Cecula P, Pedraz CT, Zimianiti I, Elsaddig M, Zhao R, Sathiyamurthy S, McEniery CM, Lees C, Banerjee Jet al., 2023, Impact of perinatal factors on biomarkers of cardiovascular disease risk in preadolescent children., Journal of Hypertension, Vol: 41, Pages: 1059-1067, ISSN: 0263-6352

BACKGROUND: This review aims to summarize associations of the perinatal environment with arterial biophysical properties in childhood, to elucidate possible perinatal origins of adult cardiovascular disease (CVD). METHODS: A systematic search of PubMed database was performed (December 2020). Studies exploring associations of perinatal factors with arterial biophysical properties in children 12 years old or less were included. Properties studied included: pulse wave velocity; arterial stiffness or distensibility; augmentation index; intima-media thickness of aorta (aIMT) or carotids; endothelial function (laser flow Doppler, flow-mediated dilatation). Two reviewers independently performed study selection and data extraction. RESULTS: Fifty-two of 1084 identified records were included. Eleven studies explored associations with prematurity, 14 explored maternal factors during pregnancy, and 27 explored effects of low birth weight, small-for-gestational age and foetal growth restriction (LBW/SGA/FGR). aIMT was consistently higher in offspring affected by LBW/SGA/FGR in all six studies examining this variable. The cause of inconclusive or conflicting associations found with other arterial biophysical properties and perinatal factors may be multifactorial: in particular, measurements and analyses of related properties differed in technique, equipment, anatomical location, and covariates used. CONCLUSION: aIMT was consistently higher in LBW/SGA/FGR offspring, which may relate to increased long-term CVD risk. Larger and longer term cohort studies may help to elucidate clinical significance, particularly in relation to established CVD risk factors. Experimental studies may help to understand whether lifestyle or medical interventions can reverse perinatal changes aIMT. The field could be advanced by validation and standardization of techniques assessing arterial structure and function in children.

Journal article

Banerjee J, McLister A, Gourin B, McClure Z, Mariampillai K, Boyle RJ, Hanna GB, Ni MZet al., 2023, Tributyrin ester-impregnated pH strips for confirming neonatal feeding tube placement: a diagnostic test accuracy study, Archives of Disease in Childhood: Fetal and Neonatal Edition, Vol: 108, Pages: 433-434, ISSN: 1359-2998

Journal article

Thomas RA, Ballard M-R, Aladangady N, Banerjee Jet al., 2023, Abdominal Near Infrared Spectroscopy can be reliably used to measure splanchnic oxygenation changes in preterm infants, Journal of Perinatology, Vol: 43, Pages: 716-721, ISSN: 0743-8346

ObjectiveNear-infrared spectroscopy (NIRS) allows assessment of regional tissue oxygen delivery and extraction. There are doubts regarding reliability of gut NIRS measurements. This study assesses reliability of NIRS for monitoring gut oxygenation.Study designSplanchnic tissue haemoglobin index (sTHI), tissue oxygenation index (sTOI) and fractional tissue oxygen extraction (sFTOE) changes during blood transfusion were measured using NIRS and compared to stable control infants. Infants were grouped into 3 chronological age groups: 1–7, 8–28 and ≥29 days of life.ResultssTHI, sTOI significantly increased, and sFTOE reduced following blood transfusion in all age group infants (n = 59), with no changes seen in control infants (n = 12). Baseline characteristics including gestational age and feed volumes did not differ between groups.ConclusionGut perfusion measured by NIRS improved in infants who received blood transfusion, a change not seen in the control group, thus suggesting NIRS is a reliable method to measure splanchnic tissue oxygenation.

Journal article

Mimoglu E, Joyce K, Mohamed B, Sathiyamurthy S, Banerjee Jet al., 2023, Variability of neonatal premedication practices for endotracheal intubation and LISA in the UK (NeoPRINT survey), Early Human Development, Vol: 183, Pages: 1-5, ISSN: 0378-3782

ObjectiveThe NeoPRINT Survey was designed to assess premedication practices throughout UK NHS Trusts for both neonatal endotracheal intubation and less invasive surfactant administration (LISA).DesignAn online survey consisting of multiple choice and open answer questions covering preferences of premedication for endotracheal intubation and LISA was distributed over a 67-day period. Responses were then analysed using STATA IC 16.0.SettingOnline survey distributed to all UK Neonatal Units (NNUs).ParticipantsThe survey evaluated premedication practices for endotracheal intubation and LISA in neonates requiring these procedures.Main outcome measuresThe use of different premedication categories as well as individual medications within each category was analysed to create a picture of typical clinical practice across the UK.ResultsThe response rate for the survey was 40.8 % (78/191). Premedication was used in all hospitals for endotracheal intubation but overall, 50 % (39/78) of the units that have responded, use premedications for LISA. Individual clinician preference had an impact on premedication practices within each NNU.ConclusionThe wide variability on first-line premedication for endotracheal intubation noted in this survey could be overcome using best available evidence through consensus guidance driven by organisations such as British Association of Perinatal |Medicine (BAPM). Secondly, the divisive view around LISA premedication practices noted in this survey requires an answer through a randomised controlled trial.

Journal article

Banerjee J, Moorthy V, Kiran P, Kishore SVK, Ekiz E, Chatterjee Ret al., 2023, Visual encoding of nudge influencers and exploring their effect on sustainable consumption among children, CLEANER AND RESPONSIBLE CONSUMPTION, Vol: 9, ISSN: 2666-7843

Journal article

Murphy C, Baskind S, Aladangady N, Banerjee Jet al., 2023, Measuring gut perfusion and blood flow in neonates using ultrasound Doppler of the superior mesenteric artery: a narrative review., Front Pediatr, Vol: 11, ISSN: 2296-2360

The gut is a relatively silent organ in utero but takes on a major role after birth for the absorption and digestion of feed for adequate nutrition and growth. The neonatal circulation undergoes a transition period after birth, and gut perfusion increases rapidly to satisfy the oxygen demand and consumption. If this process is compromised at any stage, preterm and fetal growth restricted infants are at particular risk of gut tissue injury secondary to hypoxia, leading to necrotizing enterocolitis. Feeding can also be a challenge in these high-risk groups due to gut dysmotility. Superior mesenteric artery (SMA) Doppler is a safe, bedside investigation that could rapidly aid clinicians with feeding strategies and in monitoring high-risk infants. This article aims to establish normal patterns of gut blood flow velocity in neonates using SMA Doppler and reviews how it might be used clinically in pathologic states.

Journal article

Aladangady N, Sinha A, Banerjee J, Asamoah F, Mathew A, Chisholm P, Kempley S, Morris Jet al., 2023, Comparison of clinical outcomes between active and permissive blood pressure management in extremely preterm infants., NIHR Open Res, Vol: 3

BACKGROUND: There remains uncertainty about the definition of normal blood pressure (BP), and when to initiate treatment for hypotension for extremely preterm infants. To determine the short-term outcomes of extremely preterm infants managed by active compared with permissive BP support regimens during the first 72 hours of life. METHOD: This is a retrospective medical records review of 23 +0-28 +6 weeks' gestational age (GA) infants admitted to neonatal units (NNU) with active BP support (aimed to maintain mean arterial BP (MABP) >30 mmHg irrespective of the GA) and permissive BP support (used medication only when babies developed signs of hypotension) regimens. Babies admitted after 12 hours of age, or whose BP data were not available were excluded. RESULTS: There were 764 infants admitted to the participating hospitals; 671 (88%) were included in the analysis (263 active BP support and 408 permissive BP support). The mean gestational age, birth weight, admission temperature, clinical risk index for babies (CRIB) score and first haemoglobin of infants were comparable between the groups. Active BP support group infants had consistently higher MABP and systolic BP throughout the first 72 hours of life (p<0.01). In the active group compared to the permissive group 56 (21.3%) vs 104 (25.5%) babies died, and 21 (8%) vs 51 (12.5%) developed >grade 2 intra ventricular haemorrhage (IVH). Death before discharge (adjusted OR 1.38 (0.88 - 2.16)) or IVH (1.38 (0.96 - 1.98)) was similar between the two groups. Necrotising enterocolitis (NEC) ≥stage 2 was significantly higher in permissive BP support group infants (1.65 (1.07 - 2.50)). CONCLUSIONS: There was no difference in mortality or IVH between the two BP management approaches. Active BP support may reduce NEC. This should be investigated prospectively in large multicentre randomised studies.

Journal article

Howarth C, Banerjee J, Eaton S, Aladangady Net al., 2022, Biomarkers of gut injury in neonates – where are we in predicting necrotising enterocolitis?, Frontiers in Pediatrics, Vol: 10, Pages: 1-19, ISSN: 2296-2360

Despite advances in neonatal care Necrotising Enterocolitis (NEC) continues to have a significant mortality and morbidity rate, and with increasing survival of those more immature infants the population at risk of NEC is increasing. Ischaemia, reperfusion, and inflammation underpin diseases affecting intestinal blood flow causing gut injury including Necrotising Enterocolitis. There is increasing interest in tissue biomarkers of gut injury in neonates, particularly those representing changes in intestinal wall barrier and permeability, to determine whether these could be useful biomarkers of gut injury. This article reviews current and newly proposed markers of gut injury, the available literature evidence, recent advances and considers how effective they are in clinical practice. We discuss each biomarker in terms of its effectiveness in predicting NEC onset and diagnosis or predicting NEC severity and then those that will aid in surveillance and identifying those infants are greatest risk of developing NEC.

Journal article

Howarth C, Banerjee J, Leung T, Aladangady Net al., 2022, Could Near Infrared Spectroscopy (NIRS) be the new weapon in our fight against Necrotising Enterocolitis?, Frontiers in Pediatrics, Vol: 10, Pages: 1-15, ISSN: 2296-2360

There is no ideal single gut tissue or inflammatory biomarker available to help to try and identify Necrotising Enterocolitis (NEC) before its clinical onset. Neonatologists are all too familiar with the devastating consequences of NEC, and despite many advances in neonatal care the mortality and morbidity associated with NEC remains significant. In this article we review Near Infrared Spectroscopy (NIRS) as a method of measuring regional gut tissue oxygenation. We discuss its current and potential future applications, including considering its effectiveness as a possible new weapon in the early identification of NEC.

Journal article

Mullins E, Perry A, Banerjee J, Townson J, Grozeva D, Milton R, Kirby N, Playle R, Bourne T, Lees C, PAN-COVID Investigatorset al., 2022, Pregnancy and neonatal outcomes of COVID-19: The PAN-COVID study., European Journal of Obstetrics Gynecology and Reproductive Biology, Vol: 276, Pages: 161-167, ISSN: 0301-2115

OBJECTIVE: To assess perinatal outcomes for pregnancies affected by suspected or confirmed SARS-CoV-2 infection. METHODS: Prospective, web-based registry. Pregnant women were invited to participate if they had suspected or confirmed SARS-CoV-2 infection between 1st January 2020 and 31st March 2021 to assess the impact of infection on maternal and perinatal outcomes including miscarriage, stillbirth, fetal growth restriction, pre-term birth and transmission to the infant. RESULTS: Between April 2020 and March 2021, the study recruited 8239 participants who had suspected or confirmed SARs-CoV-2 infection episodes in pregnancy between January 2020 and March 2021. Maternal death affected 14/8197 (0.2%) participants, 176/8187 (2.2%) of participants required ventilatory support. Pre-eclampsia affected 389/8189 (4.8%) participants, eclampsia was reported in 40/ 8024 (0.5%) of all participants. Stillbirth affected 35/8187 (0.4 %) participants. In participants delivering within 2 weeks of delivery 21/2686 (0.8 %) were affected by stillbirth compared with 8/4596 (0.2 %) delivering ≥ 2 weeks after infection (95 % CI 0.3-1.0). SGA affected 744/7696 (9.3 %) of livebirths, FGR affected 360/8175 (4.4 %) of all pregnancies. Pre-term birth occurred in 922/8066 (11.5%), the majority of these were indicated pre-term births, 220/7987 (2.8%) participants experienced spontaneous pre-term births. Early neonatal deaths affected 11/8050 livebirths. Of all neonates, 80/7993 (1.0%) tested positive for SARS-CoV-2. CONCLUSIONS: Infection was associated with indicated pre-term birth, most commonly for fetal compromise. The overall proportions of women affected by SGA and FGR were not higher than expected, however there was the proportion affected by stillbirth in participants delivering within 2 weeks of infection was significantly higher than those delivering ≥ 2 weeks after infection. We suggest that clinicians' thresh

Journal article

Kimkool P, Huang S, Gibbs D, Banerjee J, Deierl Aet al., 2022, Cuddling very and extremely preterm babies in the delivery room is a positive and normal experience for mothers after the birth, ACTA PAEDIATRICA, Vol: 111, Pages: 952-960, ISSN: 0803-5253

Journal article

Howarth CN, Leung TS, Banerjee J, Eaton S, Morris JK, Aladangady Net al., 2022, Regional cerebral and splanchnic tissue oxygen saturation in preterm infants – Longitudinal normative measurements, Early Human Development, Vol: 165, Pages: 1-7, ISSN: 0378-3782

BackgroundTo investigate regional splanchnic and cerebral tissue oxygen saturation in preterm infants <30 weeks gestation.MethodsCerebral (cTOI) and splanchnic (sTOI) Tissue Oxygenation Index were measured weekly in 5 min epochs for a total period of 60 min using NIRS (NIRO-300) for the first 8 weeks of life, in 48 appropriately grown preterm infants born at <30 weeks gestation. Infants who developed HPI and/or NEC (n = 12) and those that died (n = 1) were excluded from our main outcome measure of regional gut and cerebral tissue oxygenation in healthy preterm infants <30 weeks gestation.ResultsMedian birthweight 789 g (460–1486), gestational age 25+6 weeks (23+0–29+1) and 51.4% female. 217 NIRS measurements were completed across the first 8 weeks of life. Mean weekly cTOI ranged from 56.8–65.4% and sTOI ranged from 36.7–46.0%. Mean cTOI was significantly higher than mean sTOI (p < 0.001) throughout the first 8 weeks of life. Mean cTOI decreased significantly with increasing postnatal age [−0.59% each week (−1.26% to −0.07%) p = 0.04]. None of the examined confounding factors had a significant effect.ConclusionsThis is the first report of regional cerebral and splanchnic tissue oxygen saturation ranges during the first 8 weeks of life for preterm infants born at <30 weeks gestation.

Journal article

Banerjee J, Vasudevan M, Kishore SVK, Kiran Pet al., 2022, Post pandemic school reluctance-Do children require attention, support, and intervention?, ASIAN JOURNAL OF PSYCHIATRY, Vol: 67, ISSN: 1876-2018

Journal article

Mansfield RC, Kaza N, Charalambous A, Milne AC, Sathiyamurthy S, Banerjee Jet al., 2022, Cardiac Output Measurement in Neonates and Children Using Noninvasive Electrical Bioimpedance Compared With Standard Methods: A Systematic Review and Meta-Analysis*, CRITICAL CARE MEDICINE, Vol: 50, Pages: 126-137, ISSN: 0090-3493

Journal article

Chakraborty D, Banerjee J, Mehta P, Singh NPet al., 2022, The Impact of Website Design on Online Customer Buying Satisfaction and Loyalty to E-Tailers: An Exploratory Study of E-Tailers In India, INFORMATION RESOURCES MANAGEMENT JOURNAL, Vol: 35, ISSN: 1040-1628

Journal article

Cecula P, Zimianiti I, Mansfield R, Elsaddig M, Banerjee J, Sathiyamurthy S, Pedraz CTet al., 2021, 781 Impact of perinatal factors on biomarkers of cardiovascular disease risk in preadolescent children, Royal College of Paediatrics and Child Health, Abstracts of the RCPCH Conference–Online, 15 June 2021–17 June 2021, Publisher: BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health

Conference paper

Zimianiti I, Cecula P, Pedraz CT, Elsaddig M, Sathiyamurthy S, Mansfield R, Banerjee Jet al., 2021, 1398 Arterial function in preadolescent children following Kawasaki disease: a systematic review, Royal College of Paediatrics and Child Health, Abstracts of the RCPCH Conference–Online, 15 June 2021–17 June 2021, Publisher: BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health

Conference paper

Zimianiti I, Cheang C, Mansfield R, Pedraz CT, Cecula P, Elsaddig M, Sathiyamurthy S, Banerjee Jet al., 2021, 1418 Arterial function in preadolescent children with congenital heart disease: a systematic review, Royal College of Paediatrics and Child Health, Abstracts of the RCPCH Conference–Online, 15 June 2021–17 June 2021, Publisher: BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health

Conference paper

Mansfield R, Sathiyamurthy S, Lees C, Banerjee Jet al., 2021, 1253 Noninvasive continuous stroke volume monitoring in term and late preterm neonates using whole body electrical bioimpedance: a clinical validation study, Royal College of Paediatrics and Child Health, Abstracts of the RCPCH Conference–Online, 15 June 2021–17 June 2021, Publisher: BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health, Pages: A293-A294

Background Non-invasive, continuous monitoring of cardiac output (CO) could transform care of sick neonates through earlier detection and improved targeted management of cardiovascular compromise. Whole body electrical bioimpedance (WBEB) has been developed for non-invasive CO measurement but has yet to be validated for use in neonates. WBEB may have significant advantages over intermittent, operator-dependent echocardiography.Objectives This study aimed to validate WBEB (NICaS monitor, NI Medical, Israel) for use in healthy, term and late preterm neonates, compared to echocardiography.Methods Well neonates <12 hours old born to healthy mothers at ≥35 weeks gestational age were recruited. Two NICaS monitor pads were applied to supine babies in a left wrist-right ankle configuration for two hours; an echo was performed during this time by a consultant neonatologist trained in echocardiography. Left ventricular (LV) stroke volume (SV) was measured using standardised echo techniques. The NICaS monitor uses fluctuations in WBEB to calculate SV at 20-second intervals using a proprietary algorithm. The median of 15 minutes of NICaS data prior to the start of the echo for each baby was used in the analysis, since babies were more likely to become distressed during the echo, reducing the quality of the NICaS data through movement artefact. Extreme, non-physiological outlier values when babies were unsettled were excluded from NICaS SV data. R (R Core Team, 2019) software was used for data analysis, including descriptive statistics, Bland-Altman analysis and Pearson correlation.Results 35 neonates were recruited (20 females), with a median (range) gestational age of 39+1 weeks (35+6 – 42+2) and birth weight of 3.34kg (2.2–4.4kg). Monitoring was performed on day one for all babies, and additionally on day two for four babies who remained in the hospital. Five babies did not have NICaS data immediately prior to the echo due to the need to feed: therefore, we

Conference paper

Venkat R, Gupta A, Banerjee J, Chellappan RBet al., 2021, Physical Co-location: an intersection of problem-solving and vicarious learning, ACTION LEARNING, ISSN: 1476-7333

Journal article

Gupta N, Deierl A, Hills E, Banerjee Jet al., 2021, Systematic review confirmed the benefits of early skin-to-skin contact but highlighted lack of studies on very and extremely preterm infants, ACTA PAEDIATRICA, Vol: 110, Pages: 2310-2315, ISSN: 0803-5253

Journal article

Mullins E, Hudak ML, Banerjee J, Getzlaff T, Townson J, Barnette K, Playle R, Bourne T, Lees C, PAN-COVID investigators and the National Perinatal COVID-19 Registry Study Groupet al., 2021, Pregnancy and neonatal outcomes of COVID-19: co-reporting of common outcomes from PAN-COVID and AAP SONPM registries, Ultrasound in Obstetrics and Gynecology, Vol: 57, Pages: 5733-581, ISSN: 0960-7692

OBJECTIVE: Few large cohort studies have reported data on maternal, fetal, perinatal and neonatal outcomes associated with SARS-CoV-2 infection in pregnancy. We report the outcome of infected pregnancies from a collaboration formed early during the pandemic between the investigators of two registries, the UK and global Pregnancy and Neonatal outcomes in COVID-19 (PAN-COVID) study and the US American Academy of Pediatrics Section on Neonatal Perinatal Medicine (AAP SONPM) National Perinatal COVID-19 Registry. METHODS: This was an analysis of data from the PAN-COVID registry (January 1st to July 25th 2020), which includes pregnancies with suspected or confirmed maternal SARS-CoV-2 infection at any stage in pregnancy, and the AAP SONPM National Perinatal COVID-19 registry (April 4th to August 8th 2020), which includes pregnancies with positive maternal testing for SARS-CoV-2 from 14 days before delivery to 3 days after delivery. The registries collected data on maternal, fetal, perinatal and neonatal outcomes. The PAN-COVID results are presented both overall for pregnancies with suspected or confirmed SARS-CoV-2 infection and separately in those with confirmed infection. RESULTS: We report on 4005 pregnant women with suspected or confirmed SARS-CoV-2 infection (1606 from PAN-COVID and 2399 from AAP SONPM). For obstetric outcomes, in PAN-COVID overall, those with confirmed infection in PAN-COVID and AAP SONPM, respectively, maternal death occurred in 0.5%, 0.5% and 0.2% of cases, early neonatal death in 0.2%, 0.3% and 0.3% of cases and stillbirth in 0.5%, 0.6% and 0.4% of cases. Delivery was pre-term (<37 weeks' gestation) in 12.0% of all women in PAN-COVID, in 16.2% of those women with confirmed infection in PAN-COVID and in 15.7% of women in AAP SONPM. Extremely preterm delivery (< 27 weeks' gestation) occurred in 0.5% of cases in PAN-COVID and 0.3% in AAP SONPM. Neonatal SARS-CoV-2 infection was reported in 0.8% of all deliver

Journal article

Banerjee J, Mullins E, Townson J, Playle R, Shaw C, Kirby N, Munnery K, Bourne T, Teoh TG, Dhanjal M, Poon L, Wright A, Lees Cet al., 2021, Pregnancy and Neonatal Outcomes in COVID-19: Study protocol for a global registry of women with suspected or confirmed SARS-CoV-2 infection in pregnancy and their neonates, understanding natural history to guide treatment and prevention, BMJ Open, Vol: 11, Pages: 1-6, ISSN: 2044-6055

Introduction: Previous novel coronavirus pandemics, Severe Acute Respiratory Syndrome (SARS) and Middle East Respiratory Syndrome (MERS), observed an association of infection in pregnancy with pre-term delivery, stillbirth and increased maternal mortality. Coronavirus disease2019(COVID-19), caused by SARS-CoV-2 infection, is the largest pandemic in living memory. Rapid accrual of robust case data on women in pregnancy and their babies affected by suspectedCOVID-19or confirmed SARS-CoV-2 infection will inform clinical management and preventative strategies in the current pandemic and future outbreaks. Methods and analysis: The Pregnancy And Neonatal outcomes in COVID-19 (PAN-COVID) registry is an observational study collecting focussed data on outcomes of pregnant mothers who have had suspected COVID-19 in pregnancy or confirmed SARS-CoV-2 infection and their neonatesvia a web-portal. Amongst the women recruited to the PAN-COVID registry, the study will evaluate the incidence of:1. Miscarriage and pregnancy loss2. FGR and stillbirth 3. Pre-term delivery 4. Vertical transmission(suspected or confirmed) and early-onset neonatal SARS-CoV-2 infection Data will be centre based and collected on individual women and their babies. Verbal consent will be obtained, to reduce face-to-face contact in the pandemic whilst allowing identifiable data collection for linkage. Statistical analysis of the data will be carried out on a pseudonymised dataset by the study statistician. Regular reports will be distributed to collaborators on the study research questions. Ethics and dissemination: This study has received research ethics approval in the UK. For international centres, evidence of appropriate local approval will be required to participate, prior to entry of data to the database. The reports will be published regularly. The outputs of the study will be regularly disseminated to 4participants and collaborators on the study

Journal article

Howarth C, Banerjee J, Leung T, Eaton S, Morris JK, Aladangady Net al., 2020, Cerebral oxygenation in preterm infants with necrotizing enterocolitis, Pediatrics, Vol: 146, Pages: e20200337-e20200337, ISSN: 0031-4005

BACKGROUND AND OBJECTIVES: Preterm infants with necrotizing enterocolitis (NEC) are known to have worse neurodevelopmental outcomes, but there is no substantial evidence to support an underlying pathophysiology. We aimed to examine whether cerebral oxygenation differs in those infants who develop NEC compared to cerebral oxygenation in those who do not.METHODS: We examined 48 infants <30 weeks’ gestation admitted to a tertiary level NICU from October 2016 to May 2018. Infants with birth weight less than or equal to the second percentile, abnormal antenatal dopplers or twin-to-twin-transfusion-syndrome were excluded. Cerebral oximetry measurements were performed by using a near-infrared spectroscopy (NIRS) monitor weekly for 60 minutes, allowing measurement of cerebral tissue oxygenation index from the first week of life to 36 weeks postconceptional age. Weekly clinical status was also recorded. NEC was defined as greater than or equal to Bell stage 2.RESULTS: The median birth weight was 884 g (range of 460–1600 g), the median weeks’ gestational age was 26 + 3/7 (23 + 0/7 to 29 + 6/7), and 52% were girls. In total, 276 NIRS measurements were completed, and 7 infants developed NEC. NIRS measurements from 1 infant with NEC and 4 infants without NEC who developed hemorrhagic parenchymal infarcts were excluded from analysis. Infants who developed NEC had significantly lower cerebral tissue oxygenation index than those who did not (P = .011), even when adjusted for confounders, including gestational age, birth weight, patent ductus arteriosus, enteral feeds, sex, ethnicity, and hemoglobin.CONCLUSIONS: Infants with NEC have significantly lower cerebral tissue oxygenation throughout their neonatal intensive care stay in comparison with those who did not develop NEC. This is a novel finding and could explain their worse neurodevelopmental outcome.

Journal article

Banerjee J, Aloysius A, Mitchell K, Silva I, Rallis D, Godambe SV, Deierl Aet al., 2020, Improving infant outcomes through implementation of a family integrated care bundle including a parent supporting mobile application, Archives of Disease in Childhood - Fetal and Neonatal Edition, Vol: 105, Pages: 172-177, ISSN: 1359-2998

Objective The aim of the Integrated Family Delivered Care (IFDC) programme was to improve infant health outcomes and parent experience through education and competency-based training.Design In collaboration with veteran parents’ focus groups, we created an experienced co-designed care bundle including IFDC mobile application, which together with staff training programme comprised the IFDC programme. Infant outcomes were compared with retrospective controls in a prepost intervention analysis.Main outcome measures The primary outcome measure was the length of stay (LOS).Results Between April 2017 and May 2018, 89 families were recruited; 37 infants completed their entire care episode in our units with a minimum LOS >14 days. From a gestational age (GA) and birth weight-matched retrospective cohort, 57 control infants were selected. Data were also analysed for subgroup under 30 weeks GA (n=20).Infants in the IFDC group were discharged earlier: median corrected GA (36+0 (IQR 35+0–38+0) vs 37+1 (IQR 36+3–38+4) weeks; p=0.003), with shorter median LOS (41 (32–63) vs 55 (41–73) days; p=0.022). This was also evident in the subgroup <30 weeks GA (61 (39–82) vs 76 (68–84) days; p=0.035). Special care days were significantly lower in the IFDC group (30 (21–41) vs 40 (31–46); p=0.006). The subgroup of infants (<30 weeks) reached full suck feeding earlier (median: 47 (37–76) vs 72 (66–82) days; p=0.006).Conclusion This is the first reported study from a UK tertiary neonatal unit demonstrating significant benefits of family integrated care programme. The IFDC programme has significantly reduced LOS, resulted in the earlier achievement of full enteral and suck feeds.

Journal article

Dharmarajah K, Seager E, Deierl A, Banerjee J, Integrated Family Delivered Care core groupet al., 2020, Mapping family integrated care practices in the neonatal units across the UK., Arch Dis Child Fetal Neonatal Ed, Vol: 105, Pages: 111-112

Journal article

Dharmarajah K, Seager E, Deierl A, Banerjee Jet al., 2020, Mapping family integrated care practices in the neonatal units across the UK, ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION, Vol: 105, Pages: F111-+, ISSN: 1359-2998

Journal article

Seager E, Longley C, Aladangady N, Banerjee Jet al., 2020, Measurement of gut oxygenation in the neonatal population using near-infrared spectroscopy: a clinical tool?, ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION, Vol: 105, Pages: F76-F86, ISSN: 1359-2998

Journal article

Banerjee J, 2020, THE ONSET OF PLASTIC INSTABILITY AS A CRITERION FOR USEFUL DEFORMATION IN MANUFACTURING PROCESSES, 7th International Conference on Integrity-Reliability-Failure (IRF), Publisher: INEGI-INST ENGENHARIA MECANICA E GESTAO INDUSTRIAL, Pages: 1039-1040

Conference paper

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