Imperial College London
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DrJorgeBernardino de la Serna

Faculty of Medicine, National Heart & Lung Institute

Senior Lecturer in Inhalation Toxicology and Pharmacology
 
 
 
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Contact

 

+44 (0)20 7594 3277j.bernardino-de-la-serna Website

 
 
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Location

 

CubicleSir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Saeed:2023:10.1002/chem.202300617,
author = {Saeed, HK and Jarman, PJ and Sreedharan, S and Mowll, R and Auty, AJ and Chauvet, AAP and Smythe, CGW and de, la Serna JB and Thomas, JA},
doi = {10.1002/chem.202300617},
journal = {Chemistry: A European Journal},
title = {From chemotherapy to phototherapy - changing the therapeutic action of a metallo-intercalating Ru -Re luminescent system by switching its sub-cellular location},
url = {http://dx.doi.org/10.1002/chem.202300617},
volume = {29},
year = {2023}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The synthesis of a new heterodinuclear ReI RuII metallointercalator containing RuII (dppz) and ReI (dppn) moieties is reported. Cell-free studies reveal that the complex has similar photophysical properties to its homoleptic M(dppz) analogue and it also binds to DNA with a similar affinity. However, the newly reported complex has very different in-cell properties to its parent. In complete contrast to the homoleptic system, the RuII (dppz)/ReI (dppn) complex is not intrinsically cytotoxic but displays appreciable phototoxic, despite both complexes displaying very similar quantum yields for singlet oxygen sensitization. Optical microscopy suggests that the reason for these contrasting biological effects is that whereas the homoleptic complex localises in the nuclei of cells, the RuII (dppz)/ReI (dppn) complex preferentially accumulates in mitochondria. These observations illustrate how even small structural changes in metal based therapeutic leads can modulate their mechanism of action.
AU  - Saeed,HK
AU  - Jarman,PJ
AU  - Sreedharan,S
AU  - Mowll,R
AU  - Auty,AJ
AU  - Chauvet,AAP
AU  - Smythe,CGW
AU  - de,la Serna JB
AU  - Thomas,JA
DO  - 10.1002/chem.202300617
PY  - 2023///
SN  - 0947-6539
TI  - From chemotherapy to phototherapy - changing the therapeutic action of a metallo-intercalating Ru -Re luminescent system by switching its sub-cellular location
T2  - Chemistry: A European Journal
UR  - http://dx.doi.org/10.1002/chem.202300617
UR  - https://www.ncbi.nlm.nih.gov/pubmed/37013945
UR  - https://chemistry-europe.onlinelibrary.wiley.com/doi/full/10.1002/chem.202300617
UR  - http://hdl.handle.net/10044/1/108081
VL  - 29
ER  -
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