Summary
Project summary
Since October 2020, I have been conducting a convergence science PhD funded by Cancer Research UK. My research involves the generation of a prognostic multipanel test for prostate cancer which can be used directly in the clinic. This interdisciplinary work brings together the usage of loop-mediated isothermal amplification (LAMP) and ion-sensitive field-effect transistors (ISFETs) for a rapid and sensitive platform for detection of circulating biomarkers. In particular, the usage of liquid biopsies from the blood, presents the opportunity for a non-invasive prognostic test, overcoming potentially painful procedures present in current testing.
This work is supervised by Professor Pantelis Georgiou from the Centre for Bio-inspired Technology and Professor Charlotte Bevan from the Department of Surgery and Cancer.
Previous work
- MSci in Natural Sciences (Synthetic organic chemistry and molecular and cell biology) with First Class Honours from University College London (UCL). (2016-2020)
- Master's project conducted with Professor Helen Hailes from UCL, resulting in work published as part of two journal papers.
Publications
Journals
Broomfield J, Kalofonou M, Franklin S, et al., 2023, Handheld ISFET Lab-on-Chip detection of TMPRSS2-ERG and AR mRNA for prostate cancer prognostics, Ieee Sensors Letters, Vol:7, ISSN:2475-1472, Pages:1-4
Tripathi P, Gulli C, Broomfield J, et al., 2023, Classification of nucleic acid amplification on ISFET arrays using spectrogram-based neural networks., Computers in Biology and Medicine, Vol:161, ISSN:0010-4825, Pages:1-11
Broomfield J, Kalofonou M, Pataillot-Meakin T, et al., 2022, Detection of YAP1 and AR-V7 mRNA for prostate cancer prognosis using an ISFET lab-on-chip platform, Acs Sensors, Vol:7, ISSN:2379-3694, Pages:3389-3398
Roddan R, Subrizi F, Broomfield J, et al., 2021, Chemoenzymatic Cascades toward Methylated Tetrahydroprotoberberine and Protoberberine Alkaloids, Organic Letters, Vol:23, ISSN:1523-7060, Pages:6342-6347