Since October 2020, I have been conducting a convergence science PhD funded by Cancer Research UK. My research involves the generation of a prognostic multipanel test for prostate cancer which can be used directly in the clinic. This interdisciplinary work brings together the usage of loop-mediated isothermal amplification (LAMP) and ion-sensitive field-effect transistors (ISFETs) for a rapid and sensitive platform for detection of circulating biomarkers. In particular, the usage of liquid biopsies from the blood, presents the opportunity for a non-invasive prognostic test, overcoming potentially painful procedures present in current testing.
This work is supervised by Professor Pantelis Georgiou from the Centre for Bio-inspired Technology and Professor Charlotte Bevan from the Department of Surgery and Cancer.
- MSci in Natural Sciences (Synthetic organic chemistry and molecular and cell biology) with First Class Honours from University College London (UCL). (2016-2020)
- Master's project conducted with Professor Helen Hailes from UCL, resulting in work published as part of two journal papers.
et al., 2023, Handheld ISFET Lab-on-Chip detection of TMPRSS2-ERG and AR mRNA for prostate cancer prognostics, Ieee Sensors Letters, Vol:7, ISSN:2475-1472, Pages:1-4
et al., 2023, Classification of nucleic acid amplification on ISFET arrays using spectrogram-based neural networks., Computers in Biology and Medicine, Vol:161, ISSN:0010-4825, Pages:1-11
et al., 2022, Detection of YAP1 and AR-V7 mRNA for prostate cancer prognosis using an ISFET lab-on-chip platform, Acs Sensors, Vol:7, ISSN:2379-3694, Pages:3389-3398
et al., 2021, Chemoenzymatic Cascades toward Methylated Tetrahydroprotoberberine and Protoberberine Alkaloids, Organic Letters, Vol:23, ISSN:1523-7060, Pages:6342-6347