Dr James A Bull is a Royal Society University Research Fellow in the Department of Chemistry.
Dr Bull’s research focuses on the development of efficient synthetic and catalytic methods to access novel structural motifs and heterocycles of interest in drug discovery.
For further details of the Bull group, see:
James Bull graduated from the University of Cambridge in 2001 with a First Class Honours MSci degree in Natural Sciences, Chemistry and the Raphael Prize for Organic Chemistry. He then spent a year working at GlaxoSmithKline Stevenage as a Research Scientist in the Medicinal Chemistry Department.
He returned to Cambridge in 2003 to undertake PhD research with Professor Steven V Ley. He completed the total synthesis of bisoxazole antifungal natural product bengazole A and analogues.
In 2007 he joined the group of Professor André B. Charette as a Postdoctoral Fellow at Université de Montréal, Canada. Here he developed an intramolecular Simmons-Smith cyclopropanation reaction.
In 2009 he began independent research at Imperial College London as a Ramsay Memorial Research Fellow (2009-2011), working in the laboratories of Professor Alan Armstrong. From 2011 to 2015 Dr Bull held an EPSRC Career Acceleration Fellowship on "Novel strategies to access chiral heterocycles as potential lead compounds in drug discovery". In January 2016 Dr Bull started a Royal Society University Research Fellowship.
March 2019: Alex's paper on azetidine ring expansion is out in Org Lett!
December 2018: Maryne and Camille's work on azetidine Friedel-Crafts reactions is accepted in Org Lett!
December 2018: Alex's paper on the synthesis of diverse N-heterocycles by diazo–heterocycle 'stitching' is accepted in Angew. Chem. Int. Ed. Congratulations!
December 2018: Rosie's Science of Synthesis Chapter on Oxetanes and Oxetan-3-ones is published.
November 2018: Sahra, Alex, Dani and Maryne win prizes!
September 2018: Chemistry starts in our new White City Labs!
September 2018: Sahra's paper on the palladium catalysed C-H arylation of amines with transient directing groups is accepted in Chem Eur J.
September 2018: James wins the Dave Kelly Cup at the Gregynog Synthesis Meeting.
June 2018: Daniele's work on the C-H functionalisation of N-heterocycles is out now in Org. Lett. Congratulations.
May 2018: Sahra's review on transient directing groups for C-H functionalisation is online in Org. Biomol. Chem., and a 'Hot Article'.
April 2018: Our latest work on NH transfer with hypervalent iodine reagents is now out in Org. Lett.
January 2018: Rosie's paper on the synthesis of sulfanyl-oxetanes as thioester isosteres is now out in Chem. Eur. J.
Also see: @jamesabull
et al., 2019, Acid-Mediated Ring Expansion of 2,2-Disubstituted Azetidine Carbamates to 6,6-Disubstituted 1,3-Oxazinan-2-ones., Org Lett, Vol:21, Pages:1818-1822
et al., 2019, Rapid Assembly of Saturated Nitrogen Heterocycles in One-Pot: Diazo-Heterocycle "Stitching" by N-H Insertion and Cyclization., Angew Chem Int Ed Engl, Vol:58, Pages:1458-1462
Boultwood T, Bull JA, 2019, Synthesis of Selenoaziridines: A Study on Stereochemical Outcomes of the Reaction of Aziridine Radicals and Anions Generated from Iodoaziridines, Acs Omega, Vol:4, Pages:870-879
et al., 2019, Synthesis of 3,3-Diarylazetidines by Calcium(II)-Catalyzed Friedel-Crafts Reaction of Azetidinols with Unexpected Cbz Enhanced Reactivity, Organic Letters, Vol:21, ISSN:1523-7060, Pages:300-304
St John-Campbell S, Ou AK, Bull JA, 2018, Palladium-Catalyzed C(sp(3))-H Arylation of Primary Amines Using a Catalytic Alkyl Acetal to Form a Transient Directing Group, Chemistry-a European Journal, Vol:24, ISSN:0947-6539, Pages:17838-17843