Imperial College London

Dr James A Bull

Faculty of Natural SciencesDepartment of Chemistry

Research Fellow



+44 (0)20 7594 5811j.bull Website




501bMolecular Sciences Research HubWhite City Campus





Dr James A Bull is a Royal Society University Research Fellow in the Department of Chemistry.

Dr Bull’s research focuses on the development of efficient synthetic and catalytic methods to access novel structural motifs and heterocycles of interest in drug discovery.

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Biographical details

James Bull graduated from the University of Cambridge in 2001 with a First Class Honours MSci degree in Natural Sciences, Chemistry and the Raphael Prize for Organic Chemistry. He then spent a year working at GlaxoSmithKline Stevenage as a Research Scientist in the Medicinal Chemistry Department.

He returned to Cambridge in 2003 to undertake PhD research with Professor Steven V Ley. He completed the total synthesis of bisoxazole antifungal natural product bengazole A and analogues.

In 2007 he joined the group of Professor André B. Charette as a Postdoctoral Fellow at Université de Montréal, Canada. Here he developed an intramolecular Simmons-Smith cyclopropanation reaction.

In 2009 he began independent research at Imperial College London as a Ramsay Memorial Research Fellow (2009-2011), working in the laboratories of Professor Alan Armstrong. From 2011 to 2015 Dr Bull held an EPSRC Career Acceleration Fellowship on "Novel strategies to access chiral heterocycles as potential lead compounds in drug discovery". In January 2016 Dr Bull started a Royal Society University Research Fellowship.

Group News

Also see: @jamesabull

We are advertising a PhD studentship to start in October 2020, using synthesis and plant chemical to develop Smart Bioisosteres, in collaboration with Syngenta



Greed S, Briggs E, Idiris F, et al., Synthesis of Highly Enantioenriched Sulfonimidoyl Fluorides and Sulfonimidamides by Stereospecific SuFEx Reaction, Chemistry: a European Journal, ISSN:0947-6539

Tota A, Carlucci C, Pisano L, et al., 2020, Synthesis of glycosyl sulfoximines by a highly chemo- and stereoselective NH- and O-transfer to thioglycosides, Organic & Biomolecular Chemistry, ISSN:1477-0520

Dubois MAJ, Smith MA, White AJP, et al., Short Synthesis of Oxetane and Azetidine 3-Aryl-3-carboxylic Acid Derivatives by Selective Furan Oxidative Cleavage, Organic Letters, ISSN:1523-7060

Higham J, Bull JA, 2020, Copper catalysed oxidative α-sulfonylation of branched aldehydes using the acid enhanced reactivity of manganese(IV) oxide, Chemical Communications, Vol:56, ISSN:1359-7345, Pages:4587-4590

St John-Campbell S, White AJP, Bull JA, 2020, Methylene C(sp3)–H β,β′-Diarylation of Cyclohexanecarbaldehydes Promoted by a Transient Directing Group and Pyridone Ligand, Organic Letters, Vol:22, ISSN:1523-7060, Pages:1807-1812

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