Imperial College London

Dr James A Bull

Faculty of Natural SciencesDepartment of Chemistry

Reader in Synthetic Chemistry
 
 
 
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Contact

 

+44 (0)20 7594 5811j.bull Website

 
 
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Location

 

501bMolecular Sciences Research HubWhite City Campus

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Summary

 

Publications

Publication Type
Year
to

74 results found

Andresini M, Tota A, Degennaro L, Bull JA, Luisi Ret al., 2021, Synthesis and Transformations of NH‐Sulfoximines, Chemistry – A European Journal, ISSN: 0947-6539

Journal article

Rojas J, Bull J, 2021, Oxetanes and Oxetenes—Monocyclic, Comprehensive Heterocyclic Chemistry

Journal article

Craven GB, Briggs EL, Zammit CM, McDermott A, Greed S, Affron DP, Leinfellner C, Cudmore HR, Tweedy RR, Luisi R, Bull JA, Armstrong Aet al., 2021, Synthesis and Configurational Assignment of Vinyl Sulfoximines and Sulfonimidamides, The Journal of Organic Chemistry, Vol: 86, Pages: 7403-7424, ISSN: 0022-3263

Journal article

Boddy A, Bull J, 2021, Stereoselective synthesis and applications of spirocyclic oxindoles, Organic Chemistry Frontiers, Vol: 8, Pages: 1026-1084, ISSN: 2052-4110

The development of novel synthetic strategies to form new chemical entities in a stereoselective manner is an ongoing significant objective in organic and medicinal chemistry. This review analyses the development of new stereoselective approaches to spirocyclic oxindoles with spiro-(3- to 8-membered rings). It highlights the importance of these structures for applications in medicinal chemistry, as intermediates or final products in total synthesis and as model compounds for the development of enantioselective catalytic methodologies.

Journal article

Tota A, Colella M, Carlucci C, Aramini A, Clarkson G, Degennaro L, Bull JA, Luisi Ret al., 2021, N−N Bond Formation Using an Iodonitrene as an Umpolung of Ammonia: Straightforward and Chemoselective Synthesis of Hydrazinium Salts, Advanced Synthesis and Catalysis, Vol: 363, Pages: 194-199, ISSN: 1615-4150

The formation of hydrazinium salts by N−N bond formation has typically involved the use of hazardous and difficult to handle reagents. Here, mild and operationally simple conditions for the synthesis of hydrazinium salts are reported. Electrophilic nitrogen transfer to the nitrogen atom of tertiary amines is achieved using iodosylbenzene as oxidant and ammonium carbamate as the N-source. The resulting process is highly chemoselective and tolerant to other functional groups. A wide scope is reported, including examples with bioactive molecules. Insights on the structure of hydrazinium salts were provided by X-ray analysis. (Figure presented.).

Journal article

Greed S, Briggs E, Idiris F, White A, Lücking U, Bull Jet al., 2020, Synthesis of highly enantioenriched sulfonimidoyl fluorides and sulfonimidamides by stereospecific SuFEx reaction, Chemistry: A European Journal, Vol: 26, Pages: 12533-12538, ISSN: 0947-6539

Sulfonimidamides present exciting opportunities as chiral isosteres of sulfonamides, with potential for additional directional interactions. Here we present the first modular enantioselective synthesis of sulfonimidamides, including the first stereoselective synthesis of enantioenriched sulfonimidoyl fluorides, and studies on their reactivity. A new route to sulfonimidoyl fluorides is presented from solid bench-stable, NBoc-sulfinamide salt building blocks. Enantioenriched arylsulfonimidoyl fluorides are shown to be readily racemized by fluoride ions. Conditions are developed which trap fluoride, and enable the stereospecific reaction of sulfonimidoyl fluorides with primary and secondary amines (100% es) generating sulfonimidamides with up to 99% ee. Aryl and alkyl sulfonimidoyl fluoride reagents are suitable for mild late stage functionalization reactions, exemplified by coupling with a selection of complex amines in marketed drugs.

Journal article

Higham J, Bull JA, 2020, Transient imine directing groups for the C–H functionalisation of aldehydes, ketones and amines: an update 2018-2020, Organic and Biomolecular Chemistry, Vol: 18, Pages: 7291-7315, ISSN: 1477-0520

The use of pre-installed directing groups has become a popular and powerful strategy to control site selectivity in transition metal catalysed C–H functionalisation reactions. However, the necessity for directing group installation and removal reduces the efficiency of a directed C–H functionalisation method. To overcome this limitation, taking inspiration from organocatalytic methodologies, the use of transient directing groups has arisen. These methods allow for a transient ligand to be used, potentially in catalytic quantities, without the need for discrete installation or removal steps, enabling the discovery of more efficient, and mechanistically intriguing, dual catalytic methods. This review summarises recent developments in this fast moving field covering >70 new methodologies, highlighting new directing group designs and advances in mechanistic understanding. It covers progress since 2018, providing an update to our previous review of the field.

Journal article

Green SP, Wheelhouse KM, Payne AD, Hallett JP, Miller PW, Bull JAet al., 2020, On the Use of Differential Scanning Calorimetry for Thermal Hazard Assessment of New Chemistry: Avoiding Explosive Mistakes, Angewandte Chemie International Edition, Vol: 59, Pages: 15798-15802, ISSN: 1433-7851

Journal article

Dubois MAJ, Smith MA, White AJP, Lee Wei Jie A, Mousseau JJ, Choi C, Bull JAet al., 2020, Short Synthesis of Oxetane and Azetidine 3-Aryl-3-carboxylic Acid Derivatives by Selective Furan Oxidative Cleavage, Organic Letters, Vol: 22, Pages: 5279-5283, ISSN: 1523-7060

Journal article

Coleman JA, Navratna V, Antermite D, Yang D, Bull JA, Gouaux Eet al., 2020, Chemical and structural investigation of the paroxetine-human serotonin transporter complex, eLife, Vol: 9, ISSN: 2050-084X

Antidepressants target the serotonin transporter (SERT) by inhibiting serotonin reuptake. Structural and biochemical studies aiming to understand binding of small-molecules to conformationally dynamic transporters like SERT often require thermostabilizing mutations and antibodies to stabilize a specific conformation, leading to questions about relationships of these structures to the bonafide conformation and inhibitor binding poses of wild-type transporter. To address these concerns, we determined the structures of ∆N72/∆C13 and ts2-inactive SERT bound to paroxetine analogues using single-particle cryo-EM and x-ray crystallography, respectively. We synthesized enantiopure analogues of paroxetine containing either bromine or iodine instead of fluorine. We exploited the anomalous scattering of bromine and iodine to define the pose of these inhibitors and investigated inhibitor binding to Asn177 mutants of ts2-active SERT. These studies provide mutually consistent insights into how paroxetine and its analogues bind to the central substrate-binding site of SERT, stabilize the outward-open conformation, and inhibit serotonin transport.

Journal article

Tota A, Carlucci C, Pisano L, Cutolo G, Clarkson GJ, Romanazzi G, Degennaro L, Bull JA, Rollin P, Luisi Ret al., 2020, Synthesis of glycosyl sulfoximines by a highly chemo- and stereoselective NH- and O-transfer to thioglycosides, Organic & Biomolecular Chemistry, Vol: 18, Pages: 3893-3897, ISSN: 1477-0520

<p>The first highly stereoselective sulfoximine formation directly from sulfides is achieved in the preparation of unprecedented glycosyl sulfoximines. X-ray analysis and a computational model establish the configuration at sulfur.</p>

Journal article

Higham J, Bull JA, 2020, Copper catalysed oxidative α-sulfonylation of branched aldehydes using the acid enhanced reactivity of manganese(IV) oxide, Chemical Communications, Vol: 56, Pages: 4587-4590, ISSN: 1359-7345

The oxidative coupling of secondary aldehydes and sulfinate salts is achieved using copper catalysis to form a-sulfonyl aldehydes. The use of an acidic co-solvent is important to adjust the oxidation potential of MnO2 as oxidant. A broad range of sulfonylated aldehydes is prepared, and their further functionalisation is demonstrated. A dual ionic/radical pathway mechanism is proposed.

Journal article

St John-Campbell S, White AJP, Bull JA, 2020, Methylene C(sp3)–H β,β′-Diarylation of Cyclohexanecarbaldehydes Promoted by a Transient Directing Group and Pyridone Ligand, Organic Letters, Vol: 22, Pages: 1807-1812, ISSN: 1523-7060

Journal article

Green S, Wheelhouse K, Payne A, Hallett J, Miller P, Bull Jet al., 2020, Thermal stability and explosive hazard assessment of diazo compounds and diazo transfer reagents, Organic Process Research and Development, Vol: 24, Pages: 67-84, ISSN: 1083-6160

Despite their wide use in academia as metal-carbene precursors, diazo compounds are often avoided in industry owing to concerns over their instability, exothermic decomposition and potential explosive behaviour. The stability of sulfonyl azides and other diazo-transfer reagents is relatively well understood, but there is little reliable data available for diazo compounds. This work firstly collates available sensitivity and thermal analysis data for diazo-transfer reagents and diazo compounds to act as an accessible reference resource. Thermogravimetric analysis (TGA), differential scanning calorimetry (DSC) and accelerating rate calorimetry (ARC) data for the model donor/acceptor diazo compound ethyl (phenyl)diazoacetate is presented. We also present a rigorous DSC dataset with 43 other diazo compounds, enabling direct comparison to other energetic materials to provide a clear reference work to the academic and industrial chemistry communities. Interestingly, there is a wide range of onset temperatures (Tonset) for this series of compounds which varied between 75 and 160 °C. The thermal stability variation depends on the electronic effect of substituents and the amount of charge delocalisation. A statistical model is demonstrated to predict the thermal stability of differently substituted phenyl diazoacetates. A maximum recommended process temperature (TD24) to avoid decomposition is estimated for selected diazo compounds. Average enthalpy of decomposition (∆HD) for diazo compounds without other energetic functional groups is −102 kJ mol−1. Several diazo transfer reagents are analyzed using the same DSC protocol and found to have higher thermal stability, which is in general agreement with reported values. For sulfonyl azide reagents an average ∆HD of −201 kJ mol−1 is observed. High quality thermal data from ARC experiments shows the initiation of decomposition for ethyl (phenyl)diazoacetate to be 60 °C , compared to 100 °C for t

Journal article

Brown P, Tan A-C, El-Esawi MA, Liehr T, Blanck O, Gladue DP, Almeida GMF, Cernava T, Sorzano CO, Yeung AWK, Engel MS, Chandrasekaran AR, Muth T, Staege MS, Daulatabad SV, Widera D, Zhang J, Meule A, Honjo K, Pourret O, Yin C-C, Zhang Z, Cascella M, Flegel WA, Goodyear CS, van Raaij MJ, Bukowy-Bieryllo Z, Campana LG, Kurniawan NA, Lalaouna D, Huttner FJ, Ammerman BA, Ehret F, Cobine PA, Tan E-C, Han H, Xia W, McCrum C, Dings RPM, Marinello F, Nilsson H, Nixon B, Voskarides K, Yang L, Costa VD, Bengtsson-Palme J, Bradshaw W, Grimm DG, Kumar N, Martis E, Prieto D, Sabnis SC, Amer SEDR, Liew AWC, Perco P, Rahimi F, Riva G, Zhang C, Devkota HP, Ogami K, Basharat Z, Fierz W, Siebers R, Tan K-H, Boehme KA, Brenneisen P, Brown JAL, Dalrymple BP, Harvey DJ, Ng G, Werten S, Bleackley M, Dai Z, Dhariwal R, Gelfer Y, Hartmann MD, Miotla P, Tamaian R, Govender P, Gurney-Champion OJ, Kauppila JH, Zhang X, Echeverria N, Subhash S, Sallmon H, Tofani M, Bae T, Bosch O, Cuiv PO, Danchin A, Diouf B, Eerola T, Evangelou E, Filipp FV, Klump H, Kurgan L, Smith SS, Terrier O, Tuttle N, Ascher DB, Janga SC, Schulte LN, Becker D, Browngardt C, Bush SJ, Gaullier G, Ide K, Meseko C, Werner GDA, Zaucha J, Al-Farha AA, Greenwald NF, Popoola SI, Rahman MS, Xu J, Yang SY, Hiroi N, Alper OM, Baker CI, Bitzer M, Chacko G, Debrabant B, Dixon R, Forano E, Gilliham M, Kelly S, Klempnauer K-H, Lidbury BA, Lin MZ, Lynch I, Ma W, Maibach EW, Mather DE, Nandakumar KS, Ohgami RS, Parchi P, Tressoldi P, Xue Y, Armitage C, Barraud P, Chatzitheochari S, Coelho LP, Diao J, Doxey AC, Gobet A, Hu P, Kaiser S, Mitchell KM, Salama MF, Shabalin IG, Song H, Stevanovic D, Yadollahpour A, Zeng E, Zinke K, Alimba CG, Beyene TJ, Cao Z, Chan SS, Gatchell M, Kleppe A, Piotrowski M, Torga G, Woldesemayat AA, Cosacak MI, Haston S, Ross SA, Williams R, Wong A, Abramowitz MK, Effiong A, Lee S, Abid MB, Agarabi C, Alaux C, Albrecht DR, Atkins GJ, Beck CR, Bonvin AMJJ, Bourke E, Brand T, Braun RJ, Bull JA, Cardoso P, Carter Det al., 2019, Large expert-curated database for benchmarking document similarity detection in biomedical literature search, Database: the journal of biological databases and curation, Vol: 2019, Pages: 1-66, ISSN: 1758-0463

Document recommendation systems for locating relevant literature have mostly relied on methods developed a decade ago. This is largely due to the lack of a large offline gold-standard benchmark of relevant documents that cover a variety of research fields such that newly developed literature search techniques can be compared, improved and translated into practice. To overcome this bottleneck, we have established the RElevant LIterature SearcH consortium consisting of more than 1500 scientists from 84 countries, who have collectively annotated the relevance of over 180 000 PubMed-listed articles with regard to their respective seed (input) article/s. The majority of annotations were contributed by highly experienced, original authors of the seed articles. The collected data cover 76% of all unique PubMed Medical Subject Headings descriptors. No systematic biases were observed across different experience levels, research fields or time spent on annotations. More importantly, annotations of the same document pairs contributed by different scientists were highly concordant. We further show that the three representative baseline methods used to generate recommended articles for evaluation (Okapi Best Matching 25, Term Frequency–Inverse Document Frequency and PubMed Related Articles) had similar overall performances. Additionally, we found that these methods each tend to produce distinct collections of recommended articles, suggesting that a hybrid method may be required to completely capture all relevant articles. The established database server located at https://relishdb.ict.griffith.edu.au is freely available for the downloading of annotation data and the blind testing of new methods. We expect that this benchmark will be useful for stimulating the development of new powerful techniques for title and title/abstract-based search engines for relevant articles in biomedical research.

Journal article

Antermite D, Bull JA, 2019, Transition Metal-Catalyzed Directed C(sp(3))-H Functionalization of Saturated Heterocycles, SYNTHESIS-STUTTGART, Vol: 51, Pages: 3171-3204, ISSN: 0039-7881

Journal article

Croft RA, Dubois MAJ, Boddy AJ, Denis C, Lazaridou A, Voisin-Chiret AS, Bureau R, Choi C, Mousseau JJ, Bull JAet al., 2019, Catalytic Friedel-Crafts Reactions on Saturated Heterocycles and Small Rings for sp<sup>3</sup>-sp<sup>2</sup> Coupling of Medicinally Relevant Fragments, European Journal of Organic Chemistry, Vol: 2019, Pages: 5385-5395, ISSN: 1434-193X

gem-Diarylheterocycles display a wide range of biological activity. Here we present a systematic study into the formation of 4- to 6-membered O- and N-heterocycles and cyclobutanes bearing the diaryl motif through a catalytic Friedel–Crafts reaction from the corresponding benzylic alcohols. 3,3-Diaryltetrahydrofurans, 4,4-diaryltetrahydropyrans, 3,3-diarylpyrrolidines, 4,4-diaryl-piperidines, as well as diarylcyclobutanes are examined, with results for 3,3-diaryloxetanes and 3,3-diarylazetidines presented for comparison. Three catalytic systems are investigated for each substrate [Ca(II), Li(I) and Fe(III)], across preinstalled aromatic groups of differing electronic character. In most cases examined, the diaryl product is obtained directly from the alcohol with good yields using the most appropriate catalyst system. In the absence of a nucleophile, the olefins from the 5- and 6-membered substrates by elimination of water are obtained under the same reaction conditions.

Journal article

Briggs EL, Tota A, Colella M, Degennaro L, Luisi R, Bull JAet al., 2019, Synthesis of Sulfonimidamides from Sulfenamides via an Alkoxy-amino-lambda(6)-sulfanenitrile Intermediate, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, Vol: 58, Pages: 14303-14310, ISSN: 1433-7851

Journal article

St John-Campbell S, Bull JA, 2019, Base Metal Catalysis in Directed C(sp<sup>3</sup>)−H Functionalisation, Advanced Synthesis and Catalysis, Vol: 361, Pages: 3662-3682, ISSN: 1615-4150

Directed C(sp3)−H functionalisation has made enormous progress in recent years, but has largely been restricted to catalysis using noble metals, particularly palladium. However, since 2013, there have been prominent advances that exploit the reactivity of abundant first row transition metals for a multitude of new bond formations. The use of base metal catalysis for C−H functionalisation can provide huge advantages in terms of cost and sustainability compared to methods using noble metals. This review covers all examples, to the end 2018, of auxiliary-assisted, base metal-catalysed C(sp3)−H functionalisation reactions. Successful examples are reported for Fe, Co, Ni and Cu catalysis with monodentate or bidentate directing groups for C−N, C−O, C−S and C−C bond forming reactions. This review aims to highlight the current state of this field and potential for expansion and so scope and limitations are highlighted. Notably, examples to date have required sterically activated α-disubstituted substrates, particularly propanamide derivatives with bidentate directing groups, such as 8-aminoquinoline amides. Monodentate quinoline and thioamide directing groups have also been used with Co catalysis for C−N and C−C bond formations. Mechanistic details are provided to outline the nature of the proposed organometallic intermediates and potential reaction pathways. We hope this review will stimulate further developments in this growing and important field. (Figure presented.).

Journal article

St John-Campbell S, Bull JA, 2019, Intramolecular palladium(ii)/(iv) catalysed C(sp3)–H arylation of tertiary aldehydes using a transient imine directing group, Chemical Communications, Vol: 55, Pages: 9172-9175, ISSN: 1359-7345

<p>Indane-aldehydes are formed using palladium catalysis and a transient directing group to promote intramolecular C–H functionalisation with aryl bromides.</p>

Journal article

Green SP, Payne AD, Wheelhouse KM, Hallett JP, Miller PW, Bull JAet al., 2019, Diazo-Transfer Reagent 2-Azido-4,6-dimethoxy-1,3,5-triazine Displays Highly Exothermic Decomposition Comparable to Tosyl Azide, JOURNAL OF ORGANIC CHEMISTRY, Vol: 84, Pages: 5893-5898, ISSN: 0022-3263

Journal article

Dubois MAJ, Lazaridou A, Choi C, Mousseau JJ, Bull JAet al., 2019, Synthesis of 3-Aryl-3-Sulfanyl Azetidines by Iron-Catalyzed Thiol Alkylation with N-Cbz Azetidinols, Journal of Organic Chemistry, Vol: 84, Pages: 5943-5956, ISSN: 0022-3263

New small-ring derivatives can provide valuable motifs in new chemical space for drug design. 3-Aryl-3-sulfanyl azetidines are synthesized directly from azetidine-3-ols in excellent yield by a mild Fe-catalyzed thiol alkylation. A broad range of thiols and azetidinols bearing electron-donating aromatics are successful, proceeding via an azetidine carbocation. The N-carboxybenzyl group is a requirement for good reactivity and enables the NH-azetidine to be revealed. Further reactions of the azetidine sulfides demonstrate their potential for incorporation in drug discovery programs.

Journal article

Boddy AJ, Cordier C, Goldberg K, Madin A, Spivey AC, Bull Jet al., 2019, Acid-mediated ring-expansion of 2,2-disubstituted azetidine carbamates to 6,6-disubstituted 1,3-oxazinan-2-ones, Organic Letters, Vol: 21, Pages: 1818-1822, ISSN: 1523-7052

The ring expansion of 2-ester-2-aryl-azetidine carbamates can be achieved using Brønsted acids to form 6,6-disubstituted 1,3-oxazinan-2-ones. The reaction is rapid at room temperature with Boc or Cbz derivatives, and proceeds with excellent yield (up to 96%) and broad substrate scope. Derivatives of drug compounds and natural products are incorporated. The combina-tion of this ring expansion in a 3-step N–H insertion/cyclization/expansion (NICE) sequence is applied to directly access medicinally relevant scaffolds from acyclic precursors.

Journal article

Boultwood T, Bull J, 2019, Synthesis of selenoaziridines: a study on stereochemical outcomes of the reaction of aziridine radicals and anions generated from iodoaziridines, ACS Omega, Vol: 4, Pages: 870-879, ISSN: 2470-1343

The synthesis of a new functional group in the form of selenyl-substituted aziridines is described. Selenoaziridines are stereoselectively prepared by functionalization of intact aziridine precursors involving radical and anionic intermediates. Radicals are generated from cis-N-Ts iodoaziridines by activation of the C–I bond using alkoxides as a source of single electrons. These form predominantly trans-substituted seleno-aziridines dependent on the size of the diselenide. cis-Aziridinyllithiums generated by Li–I exchange also react with diselenides stereospecifically to form a range of cis-selenoaziridines. Proposals for the stereochemical outcome are presented.

Journal article

Boddy AJ, Affron DP, Cordier CJ, Rivers EL, Spivey AC, Bull JAet al., 2019, Rapid Assembly of Saturated Nitrogen Heterocycles in One-Pot: Diazo-Heterocycle "Stitching" by N-H Insertion and Cyclization, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, Vol: 58, Pages: 1458-1462, ISSN: 1433-7851

Journal article

Denis C, Dubois MAJ, Voisin-Chiret AS, Bureau R, Choi C, Mousseau JJ, Bull JAet al., 2019, Synthesis of 3,3-Diarylazetidines by Calcium(II)-Catalyzed Friedel-Crafts Reaction of Azetidinols with Unexpected Cbz Enhanced Reactivity, ORGANIC LETTERS, Vol: 21, Pages: 300-304, ISSN: 1523-7060

Journal article

St John-Campbell S, Ou AK, Bull JA, 2018, Palladium-Catalyzed C(sp(3))-H Arylation of Primary Amines Using a Catalytic Alkyl Acetal to Form a Transient Directing Group, CHEMISTRY-A EUROPEAN JOURNAL, Vol: 24, Pages: 17838-17843, ISSN: 0947-6539

Journal article

Croft RA, Bull J, 2018, Oxetanes and Oxetan-3-ones (37.3), Science of Synthesis Knowledge Updates, Vol: 4, Pages: 379-434

Journal article

Croft RA, Mousseau JJ, Choi C, Bull JAet al., 2018, Oxetane ethers are formed reversibly in the lithium-catalyzed Friedel-Crafts alkylation of phenols with oxetanols: synthesis of dihydrobenzofurans, diaryloxetanes, and oxetane ethers, Tetrahedron, Vol: 74, Pages: 5427-5435, ISSN: 0040-4020

Studies on the mechanism and intermediate products in the Friedel–Crafts reaction between oxetanols and phenols are presented. Formation of O-alkylated intermediates is identified using 1H NMR spectroscopy, in a reversible formation of the kinetic oxetane ether products. An interesting relationship between the electronic nature of the nucleophile and the degree of O-alkylation is uncovered. For phenols substituted with an electron withdrawing group such as CN, oxetane ethers are the only products isolated regardless of reaction time. Increasing the electron rich nature of the phenol leads to an increased proportion of the thermodynamic C-alkylated Friedel–Crafts products after just one hour and as the sole product/s after extended reaction times. These studies have enabled a more complete catalytic cycle to be proposed. Using the same lithium catalyst and carefully selected reaction times, several examples of oxetane ethers are successfully isolated as novel bioisosteres for ester groups.

Journal article

St John-Campbell S, Bull JA, 2018, Transient imines as ‘next generation’ directing groups for the catalytic functionalisation of C–H bonds in a single operation, Organic and Biomolecular Chemistry, Vol: 16, Pages: 4582-4595, ISSN: 1472-7781

C–H Functionalisation promises a paradigm shift in synthetic planning. However, the additional steps often required to install and remove directing groups currently detracts from the efficiency. The strategy of reversible installation of a directing group via an imine linkage has recently emerged, with the imine formed and hydrolysed in situ. Such transient directing groups can promote transition metal catalysed functionalisation of unactivated C–H bonds of aldehydes, ketones and amines. This approach removes additional steps usually required for covalent directing groups and can use catalytic quantities of the imine forming component. This review updates the rapidly developing field of transient directing groups for C–H functionalisation on sp2 and sp3 carbon centres, to form new C–C and C–X bonds. We focus on the structures of the transient directing groups as mono or bidentate coordinating groups for various metal catalysts.

Journal article

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