Imperial College London
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Dr James A Bull

Faculty of Natural Sciences, Department of Chemistry

Reader in Synthetic Chemistry
 
 
 
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Contact

 

+44 (0)20 7594 5811j.bull Website

 
 
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Location

 

501bMolecular Sciences Research HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Green:2020:10.1002/anie.202007028,
author = {Green, SP and Wheelhouse, KM and Payne, AD and Hallett, JP and Miller, PW and Bull, JA},
doi = {10.1002/anie.202007028},
journal = {Angewandte Chemie International Edition},
pages = {15798--15802},
title = {On the Use of Differential Scanning Calorimetry for Thermal Hazard Assessment of New Chemistry: Avoiding Explosive Mistakes},
url = {http://dx.doi.org/10.1002/anie.202007028},
volume = {59},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - <jats:title>Abstract</jats:title><jats:p>Differential scanning calorimetry (DSC) is increasingly used as evidence to support a favourable safety profile of novel chemistry, or to highlight the need for caution. DSC enables preliminary assessment of the thermal hazards of a potentially energetic compound. However, unlike other standard characterisation methods, which have well defined formats for reporting data, the current reporting of DSC results for thermal hazard assessment has shown concerning trends. Around half of all results in 2019 did not include experimental details required to replicate the procedure. Furthermore, analysis for thermal hazard assessment is often only conducted in unsealed crucibles, which could lead to misleading results and dangerously incorrect conclusions. We highlight the specific issues with DSC analysis of hazardous compounds currently in the organic chemistry literature and provide simple “best practice” guidelines which will give chemists confidence in reported DSC results and the conclusions drawn from them.</jats:p>
AU  - Green,SP
AU  - Wheelhouse,KM
AU  - Payne,AD
AU  - Hallett,JP
AU  - Miller,PW
AU  - Bull,JA
DO  - 10.1002/anie.202007028
EP  - 15802
PY  - 2020///
SN  - 1433-7851
SP  - 15798
TI  - On the Use of Differential Scanning Calorimetry for Thermal Hazard Assessment of New Chemistry: Avoiding Explosive Mistakes
T2  - Angewandte Chemie International Edition
UR  - http://dx.doi.org/10.1002/anie.202007028
UR  - http://hdl.handle.net/10044/1/81418
VL  - 59
ER  -
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