Imperial College London
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Dr James A Bull

Faculty of Natural Sciences, Department of Chemistry

Reader in Synthetic Chemistry
 
 
 
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Contact

 

+44 (0)20 7594 5811j.bull Website

 
 
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Location

 

501bMolecular Sciences Research HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Greed:2022:10.1039/D2CC01219G,
author = {Greed, S and Symes, O and Bull, J},
doi = {10.1039/D2CC01219G},
journal = {Chemical Communications},
pages = {5387--5390},
title = {Stereospecific reaction of sulfonimidoyl fluorides with Grignard reagents for the synthesis of enantioenriched sulfoximines},
url = {http://dx.doi.org/10.1039/D2CC01219G},
volume = {58},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Sulfonimidoyl halides have previously shown poor stability and selectivity in reaction with organometallic reagents. Here we report the preparation of enantioenriched sulfonimidoyl fluorides and their stereospecific reaction at sulfur with Grignard reagents. Notably the first enantioenriched alkyl sulfonimidoyl fluorides are prepared, including methyl. The nature of the N-group is important to the success of the stereocontrolled sequence to sulfoximines.
AU  - Greed,S
AU  - Symes,O
AU  - Bull,J
DO  - 10.1039/D2CC01219G
EP  - 5390
PY  - 2022///
SN  - 1359-7345
SP  - 5387
TI  - Stereospecific reaction of sulfonimidoyl fluorides with Grignard reagents for the synthesis of enantioenriched sulfoximines
T2  - Chemical Communications
UR  - http://dx.doi.org/10.1039/D2CC01219G
UR  - https://pubs.rsc.org/en/Content/ArticleLanding/2022/CC/D2CC01219G
UR  - http://hdl.handle.net/10044/1/96922
VL  - 58
ER  -
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