DrJosephChallenger

Faculty of Medicine, School of Public Health

Research Fellow

Contact

Location

409School of Public HealthWhite City Campus

Summary

I am a Research Fellow working in the malaria group with Tom Churcher in the Department of Infectious Disease Epidemiology. My current work includes modelling the potential impact of transmission-blocking vaccines and using experimental hut trials to evaluate novel insecticides.

I have also worked with Lucy Okell within the department, developing within-host models of both treated and untreated malaria infections.This modelling work enables us to estimate the impact that imperfect adherence to treatment has on patient outcomes.

My PhD was completed at The University of Manchester with Professor Alan McKane. My PhD work focused on stochastic population dynamics, with an emphasis on individual-based modelling. Following my PhD I spent two years at The University of Florence, working with Professor Duccio Fanelli.

Publications

Journals

Moradi Marjaneh M, Challenger J, salas A, et al.Moradi Marjaneh M, Challenger J, salas A, Gómez-Carballa A, Sivananthan A, Rivero-Calle I, Barbeito-Castiñeiras G, Foo C, Wu Y, Liew F, Jackson H, Habgood-Coote D, D'Souza G, Nichols S, Wright V, Levin M, Kaforou M, Thwaites R, Okell L, Martinon-Torres F, Cunnington A, PERFORM Consortium, GEN-COVID Study Group close, 2023, Analysis of blood and nasal epithelial transcriptomes to identify mechanisms associated with control of SARS-CoV-2 viral load in the upper respiratory tract, Journal of Infection, Vol:87, ISSN:0163-4453, Pages:538-550

Huang W, Rodrigues J, Bilgo E, et al.Huang W, Rodrigues J, Bilgo E, Tormo JR, Challenger J, Challenger JD, De Cozar-Gallardo C, Perez-Victoria I, Reyes F, Castaneda-Casado P, Gnambani EJ, Francois de Sales Hien D, Konkobo M, Urones Ruano B, Coppens I, Mendoza-Losana A, Ballell L, Diabate A, Churcher TS, Jacobs-Lorena M close, 2023, Delftia tsuruhatensis TC1 symbiont suppresses malaria transmission by anopheline mosquitoes, Science, Vol:381, ISSN:1095-9203, Pages:533-540

Challenger JD, van Beek SW, Heine RT, et al.Challenger JD, van Beek SW, Heine RT, van der Boor SC, Charles GD, Smit MJ, Ockenhouse C, Aponte JJ, McCall MBB, Jore MM, Churcher TS, Bousema T close, 2023, Modelling the impact of a highly potent Plasmodium falciparum transmission-blocking monoclonal antibody in areas of seasonal malaria transmission, Journal of Infectious Diseases, Vol:228, ISSN:0022-1899, Pages:212-223

Challenger J, Nash RK, Ngufor C, et al.Challenger J, Nash RK, Ngufor C, Sanou A, Toé KH, Moore S, Tungu PK, Rowland M, Foster GM, N'Guessan R, Sherrard-Smith E, Churcher TS close, 2023, Assessing the variability in experimental hut trials evaluating insecticide-treated nets against malaria vectors, Current Research in Parasitology & Vector-borne Diseases, Vol:3, ISSN:2667-114X, Pages:1-11

Okell LC, Kwambai TK, Dhabangi A, et al.Okell LC, Kwambai TK, Dhabangi A, Khairallah C, Nkosi-Gondwe T, Winskill P, Opoka R, Mousa A, Kühl M-J, Lucas TCD, Challenger JD, Idro R, Weiss DJ, Cairns M, Ter Kuile FO, Phiri K, Robberstad B, Mori AT close, 2023, Projected health impact of post-discharge malaria chemoprevention among children with severe malarial anaemia in Africa, Nature Communications, Vol:14, ISSN:2041-1723, Pages:1-10

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