Imperial College London
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DrJosephChallenger

Faculty of Medicine, School of Public Health

Research Fellow
 
 
 
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Contact

 

j.challenger Website

 
 
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Location

 

409School of Public HealthWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Ngufor:2022:10.1186/s12936-022-04041-9,
author = {Ngufor, C and Fagbohoun, J and Agbevo, A and Ismail, H and Challenger, JD and Churcher, TS and Rowland, M},
doi = {10.1186/s12936-022-04041-9},
journal = {Malaria Journal},
pages = {1--13},
title = {Comparative efficacy of two pyrethroid-piperonyl butoxide nets (Olyset Plus and PermaNet 3.0) against pyrethroid resistant malaria vectors: a non-inferiority assessment},
url = {http://dx.doi.org/10.1186/s12936-022-04041-9},
volume = {21},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BackgroundPyrethroid-PBO nets were conditionally recommended for control of malaria transmitted by mosquitoes with oxidase-based pyrethroid-resistance based on epidemiological evidence of additional protective effect with Olyset Plus compared to a pyrethroid-only net (Olyset Net). Entomological studies can be used to assess the comparative performance of other brands of pyrethroid-PBO ITNs to Olyset Plus.MethodsAn experimental hut trial was performed in Cové, Benin to compare PermaNet 3.0 (deltamethrin plus PBO on roof panel only) to Olyset Plus (permethrin plus PBO on all panels) against wild pyrethroid-resistant Anopheles gambiae sensu lato (s.l.) following World Health Organization (WHO) guidelines. Both nets were tested unwashed and after 20 standardized washes compared to Olyset Net. Laboratory bioassays were also performed to help explain findings in the experimental huts.ResultsWith unwashed nets, mosquito mortality was higher in huts with PermaNet 3.0 compared to Olyset Plus (41% vs. 28%, P < 0.001). After 20 washes, mortality declined significantly with PermaNet 3.0 (41% unwashed vs. 17% after washing P < 0.001), but not with Olyset Plus (28% unwashed vs. 24% after washing P = 0.433); Olyset Plus induced significantly higher mortality than PermaNet 3.0 and Olyset Net after 20 washes. PermaNet 3.0 showed a higher wash retention of PBO compared to Olyset Plus. A non-inferiority analysis performed with data from unwashed and washed nets together using a margin recommended by the WHO, showed that PermaNet 3.0 was non-inferior to Olyset Plus in terms of mosquito mortality (25% with Olyset Plus vs. 27% with PermaNet 3.0, OR = 1.528, 95%CI = 1.02–2.29) but not in reducing mosquito feeding (25% with Olyset Plus vs. 30% with PermaNet 3.0, OR = 1.192, 95%CI = 0.77–1.84). Both pyrethroid-PBO nets were superior to Olyset Net.ConclusionOlyset Plus o
AU  - Ngufor,C
AU  - Fagbohoun,J
AU  - Agbevo,A
AU  - Ismail,H
AU  - Challenger,JD
AU  - Churcher,TS
AU  - Rowland,M
DO  - 10.1186/s12936-022-04041-9
EP  - 13
PY  - 2022///
SN  - 1475-2875
SP  - 1
TI  - Comparative efficacy of two pyrethroid-piperonyl butoxide nets (Olyset Plus and PermaNet 3.0) against pyrethroid resistant malaria vectors: a non-inferiority assessment
T2  - Malaria Journal
UR  - http://dx.doi.org/10.1186/s12936-022-04041-9
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000741372000001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://malariajournal.biomedcentral.com/articles/10.1186/s12936-022-04041-9
UR  - http://hdl.handle.net/10044/1/94160
VL  - 21
ER  -
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