Imperial College London
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DrJosephChallenger

Faculty of Medicine, School of Public Health

Research Fellow
 
 
 
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Contact

 

j.challenger Website

 
 
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Location

 

409School of Public HealthWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Challenger:2023:infdis/jiad101,
author = {Challenger, JD and van, Beek SW and Heine, RT and van, der Boor SC and Charles, GD and Smit, MJ and Ockenhouse, C and Aponte, JJ and McCall, MBB and Jore, MM and Churcher, TS and Bousema, T},
doi = {infdis/jiad101},
journal = {Journal of Infectious Diseases},
pages = {212--223},
title = {Modelling the impact of a highly potent Plasmodium falciparum transmission-blocking monoclonal antibody in areas of seasonal malaria transmission},
url = {http://dx.doi.org/10.1093/infdis/jiad101},
volume = {228},
year = {2023}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Transmission-blocking interventions can play an important role in combatting malaria worldwide. Recently, a highly potent Plasmodium falciparum transmission-blocking monoclonal antibody (TB31F) was demonstrated to be safe and efficacious in malaria-naive volunteers. Here we predict the potential public health impact of large-scale implementation of TB31F alongside existing interventions. We developed a pharmaco-epidemiological model, tailored to two settings of differing transmission intensity with already established insecticide-treated nets and seasonal malaria chemoprevention interventions. Community-wide annual administration (at 80% coverage) of TB31F over a three-year period was predicted to reduce clinical incidence by 54% (381 cases averted per 1000 people per year) in a high-transmission seasonal setting, and 74% (157 cases averted per 1000 people per year) in a low-transmission seasonal setting. Targeting school-aged children gave the largest reduction in terms of cases averted per dose. An annual administration of transmission- blocking monoclonal TB31F may be an effective intervention against malaria in seasonal malaria settings.
AU  - Challenger,JD
AU  - van,Beek SW
AU  - Heine,RT
AU  - van,der Boor SC
AU  - Charles,GD
AU  - Smit,MJ
AU  - Ockenhouse,C
AU  - Aponte,JJ
AU  - McCall,MBB
AU  - Jore,MM
AU  - Churcher,TS
AU  - Bousema,T
DO  - infdis/jiad101
EP  - 223
PY  - 2023///
SN  - 0022-1899
SP  - 212
TI  - Modelling the impact of a highly potent Plasmodium falciparum transmission-blocking monoclonal antibody in areas of seasonal malaria transmission
T2  - Journal of Infectious Diseases
UR  - http://dx.doi.org/10.1093/infdis/jiad101
UR  - https://academic.oup.com/jid/advance-article/doi/10.1093/infdis/jiad101/7115792
UR  - http://hdl.handle.net/10044/1/103938
VL  - 228
ER  -
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