Imperial College London
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DrJosephChallenger

Faculty of Medicine, School of Public Health

Research Fellow
 
 
 
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Contact

 

j.challenger Website

 
 
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Location

 

409School of Public HealthWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Okell:2023:10.1038/s41467-023-35939-w,
author = {Okell, LC and Kwambai, TK and Dhabangi, A and Khairallah, C and Nkosi-Gondwe, T and Winskill, P and Opoka, R and Mousa, A and Kühl, M-J and Lucas, TCD and Challenger, JD and Idro, R and Weiss, DJ and Cairns, M and Ter, Kuile FO and Phiri, K and Robberstad, B and Mori, AT},
doi = {10.1038/s41467-023-35939-w},
journal = {Nature Communications},
pages = {1--10},
title = {Projected health impact of post-discharge malaria chemoprevention among children with severe malarial anaemia in Africa},
url = {http://dx.doi.org/10.1038/s41467-023-35939-w},
volume = {14},
year = {2023}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Children recovering from severe malarial anaemia (SMA) remain at high risk of readmission and death after discharge from hospital. However, a recent trial found that post-discharge malaria chemoprevention (PDMC) with dihydroartemisinin-piperaquine reduces this risk. We developed a mathematical model describing the daily incidence of uncomplicated and severe malaria requiring readmission among 0–5-year old children after hospitalised SMA. We fitted the model to a multicentre clinical PDMC trial using Bayesian methods and modelled the potential impact of PDMC across malaria-endemic African countries. In the 20 highest-burden countries, we estimate that only 2–5 children need to be given PDMC to prevent one hospitalised malaria episode, and less than 100 to prevent one death. If all hospitalised SMA cases access PDMC in moderate-to-high transmission areas, 38,600 (range 16,900–88,400) malaria-associated readmissions could be prevented annually, depending on access to hospital care. We estimate that recurrent SMA post-discharge constitutes 19% of all SMA episodes in moderate-to-high transmission settings.
AU  - Okell,LC
AU  - Kwambai,TK
AU  - Dhabangi,A
AU  - Khairallah,C
AU  - Nkosi-Gondwe,T
AU  - Winskill,P
AU  - Opoka,R
AU  - Mousa,A
AU  - Kühl,M-J
AU  - Lucas,TCD
AU  - Challenger,JD
AU  - Idro,R
AU  - Weiss,DJ
AU  - Cairns,M
AU  - Ter,Kuile FO
AU  - Phiri,K
AU  - Robberstad,B
AU  - Mori,AT
DO  - 10.1038/s41467-023-35939-w
EP  - 10
PY  - 2023///
SN  - 2041-1723
SP  - 1
TI  - Projected health impact of post-discharge malaria chemoprevention among children with severe malarial anaemia in Africa
T2  - Nature Communications
UR  - http://dx.doi.org/10.1038/s41467-023-35939-w
UR  - https://www.nature.com/articles/s41467-023-35939-w
UR  - http://hdl.handle.net/10044/1/102736
VL  - 14
ER  -
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