Imperial College London
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DrJamesChoi

Faculty of Engineering, Department of Bioengineering

Senior Lecturer
 
 
 
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Contact

 

+44 (0)20 7594 1777j.choi Website

 
 
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Location

 

RSM 4.06Royal School of MinesSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Saharkhiz:2018:10.1121/1.5050524,
author = {Saharkhiz, N and Koruk, H and Choi, JJ},
doi = {10.1121/1.5050524},
journal = {Journal of the Acoustical Society of America},
pages = {796--805},
title = {The effects of ultrasound parameters and microbubble concentration on acoustic particle palpation},
url = {http://dx.doi.org/10.1121/1.5050524},
volume = {144},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The elasticity of tissue-an indicator of disease progression-can be imaged by ultrasound elasticity imaging technologies. An acoustic particle palpation (APP) has recently been developed-the use of ultrasonically driven acoustic particles (e.g., microbubbles)-as an alternative method of tissue deformation. APP has the potential to improve the resolution, contrast, and depth of ultrasound elasticity imaging; but the tissue displacement dynamics and its dependence on acoustic pressure, center frequency, and microbubble concentration remains unknown. Here, displacements of at least 1 μm were produced by applying ultrasound onto a microbubble solution (concentration: 10 × 106 microbubbles ml-1) placed within a tunnel surrounded by a 5% gelatin phantom. Displacements of more than 10 μm were produced using a 1, 3.5, or 5 MHz center frequency pulse with peak-rarefactional pressures of 470, 785, and 1210 kPa, respectively. The deformation of the distal wall varied spatially and temporally according to the different parameters investigated. At low pressures, the deformation increased over several milliseconds until it was held at a nearly constant value. At high pressures, a large deformation occurred within a millisecond followed by a sharp decrease and long stabilization. Ultrasound exposure in the presence of microbubbles produced tissue deformation (p < 0.05) while without microbubbles, no deformation was observed.
AU  - Saharkhiz,N
AU  - Koruk,H
AU  - Choi,JJ
DO  - 10.1121/1.5050524
EP  - 805
PY  - 2018///
SN  - 0001-4966
SP  - 796
TI  - The effects of ultrasound parameters and microbubble concentration on acoustic particle palpation
T2  - Journal of the Acoustical Society of America
UR  - http://dx.doi.org/10.1121/1.5050524
UR  - https://www.ncbi.nlm.nih.gov/pubmed/30180665
UR  - http://hdl.handle.net/10044/1/62345
VL  - 144
ER  -
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