Imperial College London
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DrJamesChoi

Faculty of Engineering, Department of Bioengineering

Senior Lecturer
 
 
 
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Contact

 

+44 (0)20 7594 1777j.choi Website

 
 
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Location

 

RSM 4.06Royal School of MinesSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@inproceedings{Martin:2021:10.1109/IUS52206.2021.9593777,
author = {Martin, E and Hurrell, A and Choi, J and Treeby, B},
doi = {10.1109/IUS52206.2021.9593777},
publisher = {IEEE},
title = {Quantifying the effects of standing waves within the skull for ultrasound mediated opening of the blood-brain-barrier},
url = {http://dx.doi.org/10.1109/IUS52206.2021.9593777},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - CPAPER
AB  - Ultrasound mediated opening of the blood-brain barrier (BBB) has been shown to be effective in enhancing the delivery of therapeutic agents to the brain. However, challenges remain in targeting and specificity of BBB opening due to attenuation, aberration and reverberation of transcranial ultrasound fields. In this study, experimental and numerical assessment was performed of standing waves within an ex vivo human skull when delivering ultrasound pulses of varying lengths at 300 kHz using a large aperture focused ultrasound transducer. Simulations showed minimal distortion of the focal region but low amplitude standing waves were established within the skull with bursts of 50 cycles or more. Under the same conditions, the experimental measurements showed small variations in focal pressure which took 300 to 600 µs to stabilise. The pattern of sidelobes and superimposed standing waves was generally more complex when the focus was placed closer to the side and base of the skull. This data supports the use of large aperture diameter transducers and short pulse lengths for targeted BBB opening.
AU  - Martin,E
AU  - Hurrell,A
AU  - Choi,J
AU  - Treeby,B
DO  - 10.1109/IUS52206.2021.9593777
PB  - IEEE
PY  - 2021///
SN  - 1948-5719
TI  - Quantifying the effects of standing waves within the skull for ultrasound mediated opening of the blood-brain-barrier
UR  - http://dx.doi.org/10.1109/IUS52206.2021.9593777
UR  - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000832095000431&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=a2bf6146997ec60c407a63945d4e92bb
UR  - https://ieeexplore.ieee.org/document/9593777
UR  - http://hdl.handle.net/10044/1/104903
ER  -
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