Imperial College London
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DrJamesChoi

Faculty of Engineering, Department of Bioengineering

Senior Lecturer
 
 
 
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Contact

 

+44 (0)20 7594 1777j.choi Website

 
 
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Location

 

RSM 4.06Royal School of MinesSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Heymans:2017:10.1109/TUFFC.2017.2718513,
author = {Heymans, SV and Martindale, CF and Suler, A and Pouliopoulos, AN and Dickinson, RJ and Choi, JJ},
doi = {10.1109/TUFFC.2017.2718513},
journal = {IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control},
pages = {1234--1244},
title = {Simultaneous Ultrasound Therapy and Monitoring of Microbubble-Seeded Acoustic Cavitation Using a Single-Element Transducer},
url = {http://dx.doi.org/10.1109/TUFFC.2017.2718513},
volume = {64},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Ultrasound-driven microbubble (MB) activity is used in therapeutic applications such as blood clot dissolution and targeted drug delivery. The safety and performance of these technologies are linked to the type and distribution of MB activities produced within the targeted area, but controlling and monitoring these activities in vivo and in real time has proven to be difficult. As therapeutic pulses are often milliseconds long, MB monitoring currently requires a separate transducer used in a passive reception mode. Here, we present a simple, inexpensive, integrated setup, in which a focused single-element transducer can perform ultrasound therapy and monitoring simultaneously. MBs were made to flow through a vesselmimicking tube, placed within the transducer's focus, and were sonicated with therapeutic pulses (peak rarefactional pressure: 75-827 kPa, pulse lengths: 200 μs and 20 ms). The MB-seeded acoustic emissions were captured using the same transducer. The received signals were separated from the therapeutic signal with a hybrid coupler and a high-pass filter. We discriminated the MB-generated cavitation signal from the primary acoustic field and characterized MB behavior in real time. The simplicity and versatility of our circuit could make existing single-element therapeutic transducers also act as cavitation detectors, allowing the production of compact therapeutic systems with real time monitoring capabilities.
AU  - Heymans,SV
AU  - Martindale,CF
AU  - Suler,A
AU  - Pouliopoulos,AN
AU  - Dickinson,RJ
AU  - Choi,JJ
DO  - 10.1109/TUFFC.2017.2718513
EP  - 1244
PY  - 2017///
SN  - 0885-3010
SP  - 1234
TI  - Simultaneous Ultrasound Therapy and Monitoring of Microbubble-Seeded Acoustic Cavitation Using a Single-Element Transducer
T2  - IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control
UR  - http://dx.doi.org/10.1109/TUFFC.2017.2718513
UR  - http://hdl.handle.net/10044/1/54739
VL  - 64
ER  -
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