Imperial College London
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Dr Jonathan M Clarke

Faculty of Natural Sciences, Department of Mathematics

Sir Henry Wellcome Postdoctoral Fellow
 
 
 
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Contact

 

j.clarke Website

 
 
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Location

 

St Marys Multiple BuildingsSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Pi:2021:10.1101/2021.03.15.21253584,
author = {Pi, L and Expert, P and Clarke, JM and Jauneikaite, E and Costelloe, CE},
doi = {10.1101/2021.03.15.21253584},
title = {Electronic health record enabled track and trace in an urban hospital network: implications for infection prevention and control},
url = {http://dx.doi.org/10.1101/2021.03.15.21253584},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - <jats:title>ABSTRACT</jats:title><jats:p>Healthcare-associated infections represent one of the most significant challenges for modern medicine as they can significantly impact patients’lives. Carbapenemase-producing Enterobacteriaceae (CPE) pose the greatest clinical threat, given the high levels of resistance to carbapenems, which are considered as agents of ‘last resort’ against life-threatening infections. Understanding patterns of CPE infection spreading in hospitals is paramount to design effective infection control protocols to mitigate the presence of CPE in hospitals. We used patient electronic health records from three urban hospitals to: i) track microbiologically confirmed carbapenemase producing<jats:italic>Escherichia coli</jats:italic>(CP-Ec) carriers and ii) trace the patients they shared place and time with until their identification. We show that yearly contact networks in each hospital consistently exhibit a core-periphery structure, highlighting the presence of a core set of wards where most carrier-contact interactions occured before being distributed to peripheral wards. We also identified functional communities of wards from the general patient movement network. The contact networks projected onto the general patient movement community structure showed a comprehensive coverage of the hospital. Our findings highlight that infections such as CP-Ec infections can reach virtually all parts of hospitals through first-level contacts.</jats:p>
AU  - Pi,L
AU  - Expert,P
AU  - Clarke,JM
AU  - Jauneikaite,E
AU  - Costelloe,CE
DO  - 10.1101/2021.03.15.21253584
PY  - 2021///
TI  - Electronic health record enabled track and trace in an urban hospital network: implications for infection prevention and control
UR  - http://dx.doi.org/10.1101/2021.03.15.21253584
ER  -
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