Imperial College London
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Dr Jonathan M Clarke

Faculty of Natural Sciences, Department of Mathematics

Sir Henry Wellcome Postdoctoral Fellow
 
 
 
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Contact

 

j.clarke Website

 
 
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Location

 

St Marys Multiple BuildingsSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@unpublished{Beaney:2021:10.1101/2021.11.24.21266818,
author = {Beaney, T and Neves, AL and Alboksmaty, A and Flott, K and Fowler, A and Benger, JR and Aylin, P and Elkin, S and Darzi, A and Clarke, J},
doi = {10.1101/2021.11.24.21266818},
title = {Trends and associated factors for Covid-19 hospitalisation and fatality risk in 2.3 million adults in England},
url = {http://dx.doi.org/10.1101/2021.11.24.21266818},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - UNPB
AB  - <jats:title>Abstract</jats:title><jats:sec><jats:title>Background</jats:title><jats:p>The Covid-19 case fatality ratio varies between countries and over time but it is unclear whether variation is explained by the underlying risk in those infected. This study aims to describe the trends and risk factors for admission and mortality rates over time in England.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>In this retrospective cohort study, we included all adults (≥18 years) in England with a positive Covid-19 test result between 1<jats:sup>st</jats:sup>October 2020 and 30<jats:sup>th</jats:sup>April 2021. Data were linked to primary and secondary care electronic health records and death registrations. Our outcomes were i) one or more emergency hospital admissions and ii) death from any cause, within 28 days of a positive test. Multivariable multilevel logistic regression was used to model each outcome with patient risk factors and time.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>2,311,282 people were included in the study, of whom 164,046 (7.1%) were admitted and 53,156 (2.3%) died within 28 days. There was significant variation in the case hospitalisation and mortality risk over time, peaking in December 2020-February 2021, which remained after adjustment for individual risk factors. Older age groups, males, those resident in more deprived areas, and those with obesity had higher odds of admission and mortality. Of risk factors examined, severe mental illness and learning disability had the highest odds of admission and mortality.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>In one of the largest studies of nationally representative Covid-19 risk factors, case hospitalisation and mortality risk varied significantly over ti
AU  - Beaney,T
AU  - Neves,AL
AU  - Alboksmaty,A
AU  - Flott,K
AU  - Fowler,A
AU  - Benger,JR
AU  - Aylin,P
AU  - Elkin,S
AU  - Darzi,A
AU  - Clarke,J
DO  - 10.1101/2021.11.24.21266818
PY  - 2021///
TI  - Trends and associated factors for Covid-19 hospitalisation and fatality risk in 2.3 million adults in England
UR  - http://dx.doi.org/10.1101/2021.11.24.21266818
ER  -
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